ID A0A1E4RF65_9ASCO Unreviewed; 871 AA.
AC A0A1E4RF65;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=DUF221-domain-containing protein {ECO:0000313|EMBL:ODV65907.1};
GN ORFNames=HYPBUDRAFT_7245 {ECO:0000313|EMBL:ODV65907.1};
OS Hyphopichia burtonii NRRL Y-1933.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Hyphopichia.
OX NCBI_TaxID=984485 {ECO:0000313|EMBL:ODV65907.1, ECO:0000313|Proteomes:UP000095085};
RN [1] {ECO:0000313|Proteomes:UP000095085}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-1933 {ECO:0000313|Proteomes:UP000095085};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV454543; ODV65907.1; -; Genomic_DNA.
DR RefSeq; XP_020074974.1; XM_020223645.1.
DR AlphaFoldDB; A0A1E4RF65; -.
DR STRING; 984485.A0A1E4RF65; -.
DR GeneID; 30998194; -.
DR OrthoDB; 366603at2759; -.
DR Proteomes; UP000095085; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000095085};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 29..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..193
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 215..402
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 414..690
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 871 AA; 101761 MW; 7587B91EE8EF9F5D CRC64;
MISIFDGDSK NPENPNLALR QGQLRVFKTQ LVLCLWIGMS SFLLFCILRR KWPHMYAVRT
LRRNNFKNNL KSLPTDLLNW VVTLYKITDD EVLEFSGLDA YVFLSFFKMG VKIFSLLSIL
DIFILSPYRY YYTGNYDKDN ITWSAFLVSS FMNTESSHLA QDPPDFSDDF PNYFWCYPIF
TYLFSIIVYV KLFDYTKLVL KIRQKYLASQ NSITDRTIRL DGIPKRLLRK NDPSILKKFI
EELQIGKVMD VKLIYDFTPL ENLFNERNLL INNLEKLYSK TYELKIDLYN QTKTPTVITK
NSIHNNDNSN KKIVKNRNKI NDLSIKLIEI NNKIKDYQNK FDSKTSTVNI EENPEFKILP
TAFITMDSVA SAQMAAQTVL DPRVYKLMVS LAPAAKDIKW KNFRLTYYQK LFKAYLITIL
IIFSYIFVSF LVTPLSSLLD LKTISKIWPE LGDLIKKSKW LTTFVTGILP PFLFSLLNIL
LPYFYKFLSK YQGYSSNSDI ELSTLLKNFF FIFFNLFLVF IVSGTIWDYI SSISDTTKLA
YQLATSLKKL SLFYVDLILL QGLAMFPVKL LQIGDFFILN IIGKLLFLKN LILRTPRDYR
FYYYTPPIFD FGIHLPQHIL IFIIILIYSV VSTKIVTSGL VYFILGFFVY KYQLIYCFVH
PPHSTGKVWP MIFRRLMLGL GIFQIFMCGT LALEGAILLA ILCTPLVFVT LIVAWNYERY
YLPLNTFIAL KAIHNPYNFD LEFDDDNDDI LSVSKNSSSS AIAEEDEEEL ITPYNDETSL
IDNQVIDYNS NSTTKRRVST IDEEREQFTD YTYPYLIDPL NGPWIGFEGD YISMVEYNLN
QQDLEDGDMS VLSTFEDEFI LRKKLKVPEW E
//
