ID A0A1E4RFU6_9ASCO Unreviewed; 271 AA.
AC A0A1E4RFU6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Defective in cullin neddylation protein {ECO:0000256|RuleBase:RU410713};
GN ORFNames=HYPBUDRAFT_12606 {ECO:0000313|EMBL:ODV66005.1};
OS Hyphopichia burtonii NRRL Y-1933.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Hyphopichia.
OX NCBI_TaxID=984485 {ECO:0000313|EMBL:ODV66005.1, ECO:0000313|Proteomes:UP000095085};
RN [1] {ECO:0000313|Proteomes:UP000095085}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-1933 {ECO:0000313|Proteomes:UP000095085};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Neddylation of cullins play an essential role in the
CC regulation of SCF-type complexes activity.
CC {ECO:0000256|RuleBase:RU410713}.
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DR EMBL; KV454543; ODV66005.1; -; Genomic_DNA.
DR RefSeq; XP_020075072.1; XM_020219349.1.
DR AlphaFoldDB; A0A1E4RFU6; -.
DR STRING; 984485.A0A1E4RFU6; -.
DR GeneID; 30993899; -.
DR OrthoDB; 169757at2759; -.
DR Proteomes; UP000095085; Unassembled WGS sequence.
DR CDD; cd14273; UBA_TAP-C_like; 1.
DR Gene3D; 1.10.238.200; Cullin, PONY binding domain; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR014764; DCN-prot.
DR InterPro; IPR042460; DCN1-like_PONY.
DR InterPro; IPR005176; PONY_dom.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR12281:SF31; DCN1-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR12281; RP42 RELATED; 1.
DR Pfam; PF03556; Cullin_binding; 1.
DR Pfam; PF14555; UBA_4; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51229; DCUN1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000095085};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 63..264
FT /note="DCUN1"
FT /evidence="ECO:0000259|PROSITE:PS51229"
FT COILED 130..157
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 271 AA; 32647 MW; 37552290BC58B48C CRC64;
MARPLKANLK QQFISITETN STTATAWLEK YKWKLEDAMN AYLSNGGVAG EIDETNKGVT
LNDIDEDLVK IYEKYQDGQN KEIIDIDGTF QYLEDLGIDP EDMISLTLSY FLESPSTGIF
NKSSFLTRWN NEQINNLKDM KVYLEEYQKR INEDMKEFEK IYMFTFDFIK SNRIDKTVNY
ELSISYWKLL FNQRPEFQND TWERLEQWFK FVEDEYKRDF SKDSWKMFYY FVKDIISQDP
KEFKDYDEMS AWPSVIDEYV EYLRENQLLI E
//
