ID A0A1E4RR87_9ASCO Unreviewed; 863 AA.
AC A0A1E4RR87;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=DUF221-domain-containing protein {ECO:0000313|EMBL:ODV69789.1};
GN ORFNames=HYPBUDRAFT_117280 {ECO:0000313|EMBL:ODV69789.1};
OS Hyphopichia burtonii NRRL Y-1933.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Hyphopichia.
OX NCBI_TaxID=984485 {ECO:0000313|EMBL:ODV69789.1, ECO:0000313|Proteomes:UP000095085};
RN [1] {ECO:0000313|Proteomes:UP000095085}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-1933 {ECO:0000313|Proteomes:UP000095085};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KV454538; ODV69789.1; -; Genomic_DNA.
DR RefSeq; XP_020078856.1; XM_020219178.1.
DR AlphaFoldDB; A0A1E4RR87; -.
DR STRING; 984485.A0A1E4RR87; -.
DR GeneID; 30993728; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000095085; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF26; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000095085};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 591..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..160
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 183..361
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 372..645
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 774..862
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
SQ SEQUENCE 863 AA; 98181 MW; 059943E07C323B04 CRC64;
MAASAAGTST STVISTLVAN LILCGCFVTC FLILRLKFKR IYSPKSSFDL VDDEKKPDPL
PKDPFSWIYI LLTKPHSFII RQCGLDGYFF LRYILVFAVF FMFGLLTWII LLPINAANGN
GNTGLDQLSI SNVKHQQRYY AHVFVGWAFY GSLIYIIYRE LFFFNSFRTA VLSSPRYAKQ
LASRTILFQS VPDSFLDEKQ FFKLFNGVKR IYVARTARKL EAKVKQRENL ALQLEKAEHQ
LLTKAVQFKL KAEKKNITIE NPDDINSYVP EDKRPRQKEG GFFSKKIDSI NYLREEIPKI
DAEVKDLQKK YRREKPKNSI FVEFENQYVA QLAFQSTVAH NPMRLGPVYT GLAPGDIQWS
NLRLFWWERI TRRFIAASAV TALVIFWAIP VAFVGVISNI TYLTNKLPWL KWILNMPHQL
LGIITGLLPT IMLALLMALL PIFIRGMAKV AGCVSVQQIE LYTQTAYFAF LIINGFLVTT
ISSSASSTVT QIIQEPQNAM TLLASNLPKA SNFYISYLIL QGLSVAGGSL FQVVGLFLYY
IMGTLFDKTL RKKWGRFSGL GVMAWGTSFP VFTNLVCITL AYSIISPMIL LFATVAFYLI
YIAYCHNLTY VFVEGSDSRG AHYPRALFQT FTGIYLGQVC LLGLFAVGKG WGPIVLQVIA
LCFTIFCHLN LNEAFDHLLK VVPIDVMKPL DGVSETSSFW GPTDYNEKIL ERKPEYEKLT
DDLEKDEIAQ EKVKKDLLSP DIEYNSTETT NTLVPLLADR DFKSTENDNP FVRFFRPDVY
LNYRHVKQWL PAIYNTETEI VDDRHAFDAP IVSDQLLKLW IPADPMGFSK KEIEANAKII
ETTDENGSFN KKGKPIYTGP PPF
//
