ID   A0A1E4RS97_9ASCO        Unreviewed;       690 AA.
AC   A0A1E4RS97;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=PX domain-containing protein {ECO:0000259|PROSITE:PS50195};
GN   ORFNames=HYPBUDRAFT_3990 {ECO:0000313|EMBL:ODV70071.1};
OS   Hyphopichia burtonii NRRL Y-1933.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Hyphopichia.
OX   NCBI_TaxID=984485 {ECO:0000313|EMBL:ODV70071.1, ECO:0000313|Proteomes:UP000095085};
RN   [1] {ECO:0000313|Proteomes:UP000095085}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL Y-1933 {ECO:0000313|Proteomes:UP000095085};
RG   DOE Joint Genome Institute;
RA   Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA   Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA   Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA   Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA   Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA   Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA   Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT   "Comparative genomics of biotechnologically important yeasts.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004481}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   EMBL; KV454538; ODV70071.1; -; Genomic_DNA.
DR   RefSeq; XP_020079138.1; XM_020223392.1.
DR   AlphaFoldDB; A0A1E4RS97; -.
DR   STRING; 984485.A0A1E4RS97; -.
DR   GeneID; 30997941; -.
DR   OrthoDB; 5475877at2759; -.
DR   Proteomes; UP000095085; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:UniProt.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR   CDD; cd06867; PX_SNX41_42; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR044106; PX_Snx41/Atg20.
DR   PANTHER; PTHR46979; SORTING NEXIN-41; 1.
DR   PANTHER; PTHR46979:SF2; SORTING NEXIN-41; 1.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50195; PX; 1.
PE   3: Inferred from homology;
KW   Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095085}.
FT   DOMAIN          118..284
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          343..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..57
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   690 AA;  77649 MW;  1ED2D83119F74109 CRC64;
     MAPDPSHAAA TQPAGSVFDD EEDNNPFSNT QGLASLMSDH RNSLSRQAGS NGHSKRAGGE
     SQAGDKFEDD ASLLLYNSSS NNQAEVNSSP NKDTFNTIYI NYESRVTKLL RPGSNPKIQI
     TEAGNSNEGM LNSLKKYIVY TIKLINGDDL SDEIQTRRRY SDFESLRDVL TKVFPLVIVP
     PIPPKNFLGF GVLNGLVSQN ILQSTGGVAN GTGGSSADGN AASNGVGGSP SNYSYINSTH
     LNKNKLIEHR KRLLSNFLNN CLSIPQIRNL EFFAKFLDPN ANWSDEITLI TSQLPKSIYL
     LNPENGLKTD PLYENLPLPV SNHSINIPFF KDNKKKITKK TNKLLGKQSQ QNNDQEESPN
     ELSRQTSPTN TVTVDANGGG DSNNKSNYSV GDEYIIATSR LDDINKKIMD NFIGLANDYT
     ELGTAFNSFS LILSDLPITR TSKIKLSNDS SVDDRENTKL NMVFEKIGQV FDRSYITINS
     LIGDLETKFS EPLGEAVKYS DILTFINSYT RRKIRQQKLL DSEIKHRKED LFELLKQEQE
     SARIDGAINS HAIHSDHKFD FSSTNNEPAL NQTETQQANK SKFKFFPSMN QFKKITQYVT
     EIIDQNPEQT RRQRIAHLQN KITLLEKCQK IMLEDVSYIT DEVDKNFKQF HQKELKVIYE
     ILLTYNGFLI SWAKKNIDIW EEIKEEVEKL
//