ID A0A1E4RVD8_CYBJN Unreviewed; 758 AA.
AC A0A1E4RVD8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Zn-dependent exopeptidase {ECO:0000313|EMBL:ODV71210.1};
GN ORFNames=CYBJADRAFT_175345 {ECO:0000313|EMBL:ODV71210.1};
OS Cyberlindnera jadinii (strain ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617
OS / NBRC 0987 / NRRL Y-1542) (Torula yeast) (Candida utilis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Cyberlindnera.
OX NCBI_TaxID=983966 {ECO:0000313|EMBL:ODV71210.1, ECO:0000313|Proteomes:UP000094389};
RN [1] {ECO:0000313|EMBL:ODV71210.1, ECO:0000313|Proteomes:UP000094389}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617 / NBRC 0987 /
RC NRRL Y-1542 {ECO:0000313|Proteomes:UP000094389};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; KV453943; ODV71210.1; -; Genomic_DNA.
DR RefSeq; XP_020068249.1; XM_020216690.1.
DR AlphaFoldDB; A0A1E4RVD8; -.
DR STRING; 983966.A0A1E4RVD8; -.
DR GeneID; 30991086; -.
DR OMA; QGSTEWV; -.
DR OrthoDB; 67337at2759; -.
DR Proteomes; UP000094389; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000094389};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 191..267
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 366..562
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 634..756
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 758 AA; 85149 MW; 726129D231AE51F5 CRC64;
MNSVASSHIY DNDQSSIVTA YHSIRDYVKE RYPSLTTRKF LAAIVWSIVA VGIFNLIFLP
RTSLGRDYRR LHFSALTKDE TERLFLKALN EENNAGEQLR QYMKRQHLSG DGDEYVQYTM
EQLRQYGLKP YKEVYYTWMT KHVESTVSVF DEQGSLVYSP SLLEVDPVSG VSSQGYHAYS
GSGDVTAPYI FVNYGSLDDY RKLRNLGVDL KGKIHIIRTG KVSTALQVEH AESNGAVGVI
TYMDPSDDGK FTTKNGFEQY PDGPARNTSS VKRDTVLRYS QAPGDPTTIG FPSNRAVKRR
KPHNLPKIPS IPMSADKITP ILQRIPSSHD LNWTGDIEGF DYSCGPSNFT INLVNHNEAE
VVPLKNIMYE IPGLLSEKVI LGNHRDSLTM AGAADPGSGT AILLEISRAF GSLIKLGWRP
LRTIVVASWD GSAHGMLGST EYAESHEVDL QAHAIAYINL DAGVTGHNLD IVSNPLLDHF
LIGASKNIPF NNYSDTKSLF DYWEESHLGS EKINRLGSGS DFTVFQHHLG IPSCNVGFHG
DPNDSLPVNI GSSFDTLDWM ERFVDPNYEY HGTMAKYLGF LALSLSEHEV IEYKVEHYAH
EIKGYFNDLI SIIPSSWWDR DVERGTSMSL AIDQVKYLIE QLLTVSTNFD RTAQLLQEQI
SVDYPWFQFY IKLRLAMNSK IIGNKAKDID QMFLTNKGIK GRPWMKHLVF APDRDTGDDV
SLLPSLRESL ADGEFDAFIA SLQDIASALR RATKRLRL
//
