ID A0A1E4RWP0_CYBJN Unreviewed; 717 AA.
AC A0A1E4RWP0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=SPX-domain-containing protein {ECO:0000313|EMBL:ODV71693.1};
GN ORFNames=CYBJADRAFT_131231 {ECO:0000313|EMBL:ODV71693.1};
OS Cyberlindnera jadinii (strain ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617
OS / NBRC 0987 / NRRL Y-1542) (Torula yeast) (Candida utilis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Cyberlindnera.
OX NCBI_TaxID=983966 {ECO:0000313|EMBL:ODV71693.1, ECO:0000313|Proteomes:UP000094389};
RN [1] {ECO:0000313|EMBL:ODV71693.1, ECO:0000313|Proteomes:UP000094389}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617 / NBRC 0987 /
RC NRRL Y-1542 {ECO:0000313|Proteomes:UP000094389};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004128}.
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DR EMBL; KV453939; ODV71693.1; -; Genomic_DNA.
DR RefSeq; XP_020068732.1; XM_020212972.1.
DR AlphaFoldDB; A0A1E4RWP0; -.
DR STRING; 983966.A0A1E4RWP0; -.
DR GeneID; 30987368; -.
DR OMA; AGGKQQN; -.
DR OrthoDB; 11387at2759; -.
DR Proteomes; UP000094389; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033254; C:vacuolar transporter chaperone complex; IEA:UniProt.
DR GO; GO:0006799; P:polyphosphate biosynthetic process; IEA:UniProt.
DR CDD; cd07751; PolyPPase_VTC4_like; 1.
DR CDD; cd14480; SPX_VTC2_like; 1.
DR Gene3D; 3.20.100.30; VTC, catalytic tunnel domain; 1.
DR InterPro; IPR003807; DUF202.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR018966; VTC_domain.
DR InterPro; IPR042267; VTC_sf.
DR PANTHER; PTHR46140; VACUOLAR TRANSPORTER CHAPERONE 1-RELATED; 1.
DR PANTHER; PTHR46140:SF1; VACUOLAR TRANSPORTER CHAPERONE 4; 1.
DR Pfam; PF02656; DUF202; 1.
DR Pfam; PF09359; VTC; 1.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000094389};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..148
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REGION 521..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 717 AA; 81654 MW; 65BF149DF57FEE43 CRC64;
MKFGEHLKSS LIRDYNFYYI SYDELKGELK SGLQQNGNVW TDELEEKFLT SLEAELDKVY
TFQKVKRQEI VRRIKDAEHS VTEVLAMLES GAPPFEQDFE DLEEELSDVI ADVHDLAKFT
RLNYTGFQKI IKKHDKQTSW TLKPIFQVRL DAKPFFKDNY DPMIVKLSGL YDLVRTRGNP
VKGDSAAGGS QQNFVRQTTK YWVHPDNITE LKLIILKHLP VLVFNANKDF EVEDSAITSI
YYDNENMDLY YGRLRKDEGA EAHRLRWYGG MSSDTIFVER KTHREDWTGE NSVKARFPLK
ERHVNAFMKG EYTVPQAFEK MRKDGKKSLK EIEGLEALAT EVQYTMLKKR LRPVMRSFYN
RTAFQLPGDA RVRISLDTEL TMVREDNFDG VDRTKGNWRR MDIGVDWPFS QLPPKDVERF
PYAVLEVKLQ TQMGQEPPQW VRDLISSHLV EAVPKFSKFI HGCASLLPER VDLIPFWLPQ
MGVDIRKPVL SNEIGIHRNV DSNNNTSSGE YMDEEEAIGT GVGSSTQFGA IGESSQQGTQ
PNTQGVSESS PLLSSGGNGA TTRLSSSNPV VAWYNSAVAS IEDFFTDENT YKVSKDTIFE
SRFKAPPGKK ICVPVRVEPK VYFATERTYL SWISIALILS ATTTTLLSYG DRVSLAASVG
FYLTTVGTIV YASVMYMWRV INIRAKVAAN YDDKYGPTLI CSALALSVFA TFLFRVL
//
