ID A0A1E4RXL5_CYBJN Unreviewed; 663 AA.
AC A0A1E4RXL5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Lysophospholipase {ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|RuleBase:RU362103};
GN ORFNames=CYBJADRAFT_28533 {ECO:0000313|EMBL:ODV71825.1};
OS Cyberlindnera jadinii (strain ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617
OS / NBRC 0987 / NRRL Y-1542) (Torula yeast) (Candida utilis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Cyberlindnera.
OX NCBI_TaxID=983966 {ECO:0000313|EMBL:ODV71825.1, ECO:0000313|Proteomes:UP000094389};
RN [1] {ECO:0000313|EMBL:ODV71825.1, ECO:0000313|Proteomes:UP000094389}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617 / NBRC 0987 /
RC NRRL Y-1542 {ECO:0000313|Proteomes:UP000094389};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
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DR EMBL; KV453938; ODV71825.1; -; Genomic_DNA.
DR RefSeq; XP_020068864.1; XM_020217630.1.
DR AlphaFoldDB; A0A1E4RXL5; -.
DR STRING; 983966.A0A1E4RXL5; -.
DR GeneID; 30992026; -.
DR OMA; HANQSEL; -.
DR OrthoDB; 1980513at2759; -.
DR Proteomes; UP000094389; Unassembled WGS sequence.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF56; MEIOTIC PHOSPHOLIPASE SPO1-RELATED; 1.
DR Pfam; PF01735; PLA2_B; 2.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW ProRule:PRU00555};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Reference proteome {ECO:0000313|Proteomes:UP000094389}.
FT DOMAIN 1..663
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
SQ SEQUENCE 663 AA; 75543 MW; 7FF9AC579A43A6EB CRC64;
MSLQKFLNRV KIPGLDVKRF TLSTSKPLNL AIAISGGGYR ASLTALGFLT ALDDRSSRSM
DEGHLGGLLQ SASYISSISG GTWTLMSLSL SDFIPLVRLR NEWDINEPLL EGVPSLKMMD
VSRNEIQVLP PEIRAVDDSE FYDKLNNNRN KRDFGTTGDE SFDDFYAYME LLPDLDESSH
LVERDELKKD DTDWLETFKT FFRDMFKKKE DAKTVQNLLP DVEFAPVLSF KSMKKILNFY
KNLHVEVRAK KAAGFPVSFT DYWGRALSRR VFPKSARAPN TTLSGVIDLP SFKRYQQPYP
VIISNLREPG IETTSVNSSI FEFTPYEFGS WDSQMFVKMK YLGSSMYDGR PLIHINNRSV
CYVGFDNAGF ITGTSSSLFN NVLIYIWNLA ASSTRDNFRA IKAVLNTFGL TSTQDTVDPK
KHPDYALYSP NPFFRYGDAK LSPIYNSKHL FMVDGGEDGQ NIPYQPFLQP DRQVDVILSV
DSTSDTEGWP NGTIVENTYL RYNDSGHTTT TITVNGMIKN INLFPEIPTP SEFVAQGLNK
RPVFFGCHLE KYRQRYDSLP KSRYVNSFLP PIVGLFSNSE YSYSSNTSTF RVSYDDAEMS
KMIQNAYNIA TYANSTIDRD YPRCIGCILI KREFDRKERS LSLLNNMTLP EFCYNCYSKY
CYN
//
