ID   A0A1E4RZI5_CYBJN        Unreviewed;       615 AA.
AC   A0A1E4RZI5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Acyltransferase ChoActase/COT/CPT {ECO:0000313|EMBL:ODV72659.1};
GN   ORFNames=CYBJADRAFT_18598 {ECO:0000313|EMBL:ODV72659.1};
OS   Cyberlindnera jadinii (strain ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617
OS   / NBRC 0987 / NRRL Y-1542) (Torula yeast) (Candida utilis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Cyberlindnera.
OX   NCBI_TaxID=983966 {ECO:0000313|EMBL:ODV72659.1, ECO:0000313|Proteomes:UP000094389};
RN   [1] {ECO:0000313|EMBL:ODV72659.1, ECO:0000313|Proteomes:UP000094389}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617 / NBRC 0987 /
RC   NRRL Y-1542 {ECO:0000313|Proteomes:UP000094389};
RX   PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA   Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA   Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA   Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA   Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA   Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA   Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA   Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA   Jeffries T.W.;
RT   "Comparative genomics of biotechnologically important yeasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR   EMBL; KV453934; ODV72659.1; -; Genomic_DNA.
DR   RefSeq; XP_020069698.1; XM_020217195.1.
DR   AlphaFoldDB; A0A1E4RZI5; -.
DR   STRING; 983966.A0A1E4RZI5; -.
DR   GeneID; 30991591; -.
DR   OMA; MAMSSYE; -.
DR   OrthoDB; 1429709at2759; -.
DR   Proteomes; UP000094389; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589:SF115; CARNITINE O-ACETYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000094389};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801}.
FT   DOMAIN          30..598
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        326
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   615 AA;  70904 MW;  A7CC88959DEC9DED CRC64;
     MFKRMGRKFS TYAPKFKGET YKFQDQLPSL PVPTLEATRA RYLKSIKPFV ASEQEYKEHE
     ALVDDFFKTQ APALQERLTE LQATSRNWLS KYWDDYAYLQ YNDPVVPYVS YYYGHKPLPH
     ELRSIGKNQL YKTVAIIEKV TDFIELLKNE TLPPEVIRGT PYCMKSFQVM FNNSRYPKEL
     GQDSNVFYSL EENGFVVVIK NNHFFKLYTH KGQERLPSSE VHKQLIDIVR IANGLPKGKA
     VGALTTLPRD QWFHAYQELN KSPINVASIT DIHKSAFIIT LEDEQPVTYE DRAHFAWHGN
     GENRFFDKPI QFFVAKNGYS AFIAEHSKMD GTPTLLLNEV VNRELHKLNP QEFLKSLEFG
     ISEQGSVEAR HLRFEVSPVV ESAIADAKAN FKSEIDNHDV SVFHYNKYGK NQIKQFKTSP
     DAFIQMIIQL GFYKMSGTVW PTYEAASTRK FYGGRTEATR SVSEESLRFV QNWENPSVSD
     AQRAADFQEA VKSHMEYIRA ASNGEGCDRH LLGLKFQLKD GEKPHPLFSD PLFNYSSTWL
     ISTSQLSSNY HDAYGWSEVN PIGWGLAYQV NNDFLHINVC TRRSSGNDSK TLRFYLEEAA
     TEIFEVLIKQ QKPKL
//