ID A0A1E4S106_CYBJN Unreviewed; 1351 AA.
AC A0A1E4S106;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Flavodoxin-like domain-containing protein {ECO:0000259|PROSITE:PS50902};
GN ORFNames=CYBJADRAFT_98005 {ECO:0000313|EMBL:ODV73161.1};
OS Cyberlindnera jadinii (strain ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617
OS / NBRC 0987 / NRRL Y-1542) (Torula yeast) (Candida utilis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Cyberlindnera.
OX NCBI_TaxID=983966 {ECO:0000313|EMBL:ODV73161.1, ECO:0000313|Proteomes:UP000094389};
RN [1] {ECO:0000313|EMBL:ODV73161.1, ECO:0000313|Proteomes:UP000094389}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617 / NBRC 0987 /
RC NRRL Y-1542 {ECO:0000313|Proteomes:UP000094389};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- COFACTOR:
CC Name=siroheme; Xref=ChEBI:CHEBI:60052;
CC Evidence={ECO:0000256|ARBA:ARBA00001929};
CC -!- SIMILARITY: Belongs to the nitrite and sulfite reductase 4Fe-4S domain
CC family. {ECO:0000256|ARBA:ARBA00010429}.
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DR EMBL; KV453932; ODV73161.1; -; Genomic_DNA.
DR RefSeq; XP_020070200.1; XM_020218043.1.
DR STRING; 983966.A0A1E4S106; -.
DR GeneID; 30992439; -.
DR OMA; YGSYTQV; -.
DR OrthoDB; 5474937at2759; -.
DR Proteomes; UP000094389; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.30.413.10; Sulfite Reductase Hemoprotein, domain 1; 2.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR005117; NiRdtase/SiRdtase_haem-b_fer.
DR InterPro; IPR036136; Nit/Sulf_reduc_fer-like_dom_sf.
DR InterPro; IPR006067; NO2/SO3_Rdtase_4Fe4S_dom.
DR InterPro; IPR045169; NO2/SO3_Rdtase_4Fe4S_prot.
DR InterPro; IPR045854; NO2/SO3_Rdtase_4Fe4S_sf.
DR InterPro; IPR006066; NO2/SO3_Rdtase_FeS/sirohaem_BS.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11493:SF47; SULFITE REDUCTASE [NADPH] SUBUNIT BETA; 1.
DR PANTHER; PTHR11493; SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF01077; NIR_SIR; 1.
DR Pfam; PF03460; NIR_SIR_ferr; 2.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00397; SIROHAEM.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF56014; Nitrite and sulphite reductase 4Fe-4S domain-like; 2.
DR SUPFAM; SSF55124; Nitrite/Sulfite reductase N-terminal domain-like; 2.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
DR PROSITE; PS00365; NIR_SIR; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000094389}.
FT DOMAIN 593..742
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
SQ SEQUENCE 1351 AA; 150063 MW; C203048C86049AEA CRC64;
MTLLSDFYTA IGGKSVVSKK TRASAAPISS PTLELLDSTD PLATVVELQQ QLEEGEPLSV
FTSDSVLVKS LPHLQQLKDV VLNVDLKDYQ SVIAVKDLDF VTLISKNNSD LAKFLVLSHV
IVKNLGRPVF HFIDHAAIAQ DSSVAKLEKS QLPVVDIKVF RPLDTSKIVK ALPSSVENIA
LVQQSYSKPA SKFSPFLLEF FQDGSLLVDS GIKKITASYV GDNSDLDSLV KVLLSNLALD
NPIQNLYFGE EQQQSTVDSE AVSKVSKLED SYTTILNNLF GSNLDLLNQF QSTNVSTSNP
EFGFGKFIHK KEQLQQLISL VTDSLDKFLT PRASELVEKL TKWLVHARAG KTTDASLVSS
IVEILEGDSS DAAQQILSLK DAFNIQSSWL IGSDSWAYDL GSSGVHHVLS SNQDINMLIL
DNEPLSSKTE EKPFSVQRKK DIGLYAMNYG NAYVGSIAIY SSYTQVLTTL IEASQFDGPS
VVLAYLPITS ENDTPLDILK NTKQAVDSGY IPLYRYNPTL ENEDSFKLDS TVIKEQLKSF
LDRENKLTLL SQKNPQFART LEQSQSSLIK QKQDRRAREA YSQLLEGLSG PPLSIYFASD
GGSAENVAKK LGKRATQRGL KATVLSMDDI VLEDLPTEEN IVFVTSTSGQ GEFPQNGKGF
WDAIKASGDL DLAFSKISVF GLGDSLYWPR AQDKHYYNKP AKDLFNRLTF LNAKELCPLG
LGDDQDADGF NTGYNLWEPE LWKALGVDDI KTADEPPPIT NEDIKAASNF LRGTIAEGLV
DESTGAISAH DQQLTKFHGI YMQDDRDLRD SRKAAGLEPY YIFMARVRLP GGVTTPEQWL
ALDKLANETG NGTIKLTTRA TYQLHGVVKH NLKHAIRGMN AALMDTLGAC GDVNRNVMIS
ALPGNAKVHG EVEAVAKKIS EHLLPQTTAY HEIWLEGKDE RDDDPSWTDT FENRKEGPKK
VKTMVAGNAL VDNEPLYGPL YLPRKFKINI TVPPYNDVDV WSSDVGLIAV IEDNVCVGFN
VLVGGGMGST HNNKKTYPRT GSHFGFVYYD EIHTVCEKIM LVQRDFGNRK DRKNARLKYT
VDTLGPDVYK SKVEELWGKK FEAERSYEIK DNIDHFGWTQ DELNQHHFTC FIENGRVEDS
AELPQKTGLK KIAEYFQSRP GSKGSFRLTG NQHVLISCVS DEELPAVKEL MAQYKLDNTA
FSGLRLSSAA CVAFPTCGLA MAEAERYLPV MISKLEEALE EYGLKHDSIV MRMTGCPNGC
ARPWLAEVAL VGKAYGTYNL MLGGGYYGQR LNKIYRQSIK EDEVLAILKP LFKRWALERE
EGEHFGDFCI RIGVIKPTLE GKYFHDDIPE Q
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