ID A0A1E4SID9_9ASCO Unreviewed; 1507 AA.
AC A0A1E4SID9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=CANTADRAFT_51274 {ECO:0000313|EMBL:ODV79273.1};
OS Suhomyces tanzawaensis NRRL Y-17324.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Suhomyces.
OX NCBI_TaxID=984487 {ECO:0000313|EMBL:ODV79273.1, ECO:0000313|Proteomes:UP000094285};
RN [1] {ECO:0000313|Proteomes:UP000094285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-17324 {ECO:0000313|Proteomes:UP000094285};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV453912; ODV79273.1; -; Genomic_DNA.
DR RefSeq; XP_020064395.1; XM_020209921.1.
DR STRING; 984487.A0A1E4SID9; -.
DR GeneID; 30984057; -.
DR OrthoDB; 211439at2759; -.
DR Proteomes; UP000094285; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR CDD; cd05778; DNA_polB_zeta_exo; 1.
DR CDD; cd05534; POLBc_zeta; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR030559; PolZ_Rev3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR45812; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45812:SF1; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000094285};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 712..839
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 905..1360
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 1507 AA; 172874 MW; 9B18043FF1504038 CRC64;
MPNDLSIQIN DYDTYQAAPS KLDHLYSHVS QVPIIRIYGS ISVVNPHKRR RPQNATAPSP
PSSCYNVLVH VHNFYPYIYV DCHEDLPGPE HLQYLTGHIE AALAESFAKS RSRAAANDDD
DDDGDDDIAP ASPSIRKYIA NVSVGKGTPI YGFQLGLQKF YKISLLAARH KTRLIKLVQS
KAINFSGLNS PSASRNVYEG HLTHLVQFLT DFNLFGCGWL NVSTDGVYFR SPIINPALAR
FHTSDQVSTL VEFLQAYISH SNVLASLGKG QLESQLDSST GMVNFDRIGK SMLELDITTK
DISNRQWLVQ RDPHLDFNEL RHFRQKLQEG THTPTPPQIY LSSLQHVDAD LKFQCEMKQL
TLDKAPSIYI PSEFQLPFGV HFLGTGSTTW SNQKELDDLL AYAIKLNTPT QMDIDTYSKK
VLKKPRQKSI VSAKYPDILF RTCFELVDYE SHLKHHDFVL QTGPDLVQWT DYASLFTNSS
KLQIPSSFEP HPHSQPGSID VDVAFGPIAY EVPVPAELEK SFISETFDQM GILEINYPDP
FYDNEADVPA KPMVFANKKI PVPLVNESTL ASLPVSAMIE NYMKEHPVKE KHTKSYGKAS
WEYSIEPPSK EEMDEWLKEE EEYKKQKYLK FRSQIEPGIT QSHFKFTYNS LKVQRKPNDF
NNLSNFFLEI HSNNFSKDHL PNPACDPPTI LLYHFDDAND MFTSNTLTTG ILIFSNKHEA
KTMSSLLQAL DIPIELFQHE LDMIKRLVEL VELFDPDILS GYEVNASSWG YLVERVRTKY
DLNLLASLGR GHWKSNGKFG DRWGYTHTSN LTVNGRHVFN VWRILRSELS LTSYTFENVC
FHLLHQTIPK YSNYQLTEWF NTPIFLLNIM MLKYYLQRID LTLKMITVRE LISRNVEHSR
LIGIDFNSNF YRGSQFKVES ILSRITKLEN ILLNSPSKDQ VQKMRPIECI PLVMEPDSNF
YKSPMVVLDF QSLYPSIMIA YNYCYSTIVA RLHNFNPKKN ILGYLKHVPL PSGMIDLLMK
EDGLNVSPNG YVFVKSHIRK SILAKMLEEI LNTRILVKTV MKLFKEDKEL NKLYNARQLA
LKLIANVTYG YTSATFSGRM PNLDVSDAIV ATGREILTQS IELIEGGDFG AKVVYGDTDS
LFVYFPGKSK DEAFRIGKNI AEYVTNQFPD PIFLKFEKVY HPCVLLSKKR YVGYKFESED
QKVASFEAKG IETVRRDGIP AQQKIVEKAL RILFESKNLS NVKHYTLTQF LKIVTNKIAI
NDFCFAKEVR YGTYKDERYL PPGAIIAEKN VIKDARKEPQ YRERVAYLVI KDSSKPRIKD
RCITPEEFLE SFKTSSPYNL DYDYYITRVL SPPLERIFNL IGADIKAWYR EIPKFIKGTM
TNKGMETKTL LDLNEFIQAN SCLNCSTELP AMYDFMLCRE CKSDELRLMT NFSMDRKHSQ
LKRFGVDQIC DSCVTTNLLV AGGVVKNFCM EECSNYSCNV LYRKAAVRNE GRINEEISAR
VFDEMEW
//