ID   A0A1E4SUF3_9ASCO        Unreviewed;       963 AA.
AC   A0A1E4SUF3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=26S proteasome regulatory subunit RPN2 {ECO:0000256|PIRNR:PIRNR015947};
GN   ORFNames=CANARDRAFT_9962 {ECO:0000313|EMBL:ODV83111.1};
OS   [Candida] arabinofermentans NRRL YB-2248.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Ogataea; Ogataea/Candida clade.
OX   NCBI_TaxID=983967 {ECO:0000313|EMBL:ODV83111.1, ECO:0000313|Proteomes:UP000094801};
RN   [1] {ECO:0000313|Proteomes:UP000094801}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL YB-2248 {ECO:0000313|Proteomes:UP000094801};
RG   DOE Joint Genome Institute;
RA   Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA   Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA   Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA   Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA   Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA   Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA   Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT   "Comparative genomics of biotechnologically important yeasts.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       {ECO:0000256|PIRNR:PIRNR015947}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC       {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
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DR   EMBL; KV453868; ODV83111.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1E4SUF3; -.
DR   STRING; 983967.A0A1E4SUF3; -.
DR   OrthoDB; 151732at2759; -.
DR   Proteomes; UP000094801; Unassembled WGS sequence.
DR   GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR016642; 26S_Psome_Rpn2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR   InterPro; IPR048570; PSMD1_RPN2_N.
DR   InterPro; IPR040623; RPN2_C.
DR   PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR   Pfam; PF13646; HEAT_2; 1.
DR   Pfam; PF01851; PC_rep; 2.
DR   Pfam; PF18004; RPN2_C; 1.
DR   Pfam; PF21505; RPN2_N; 1.
DR   PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW   Reference proteome {ECO:0000313|Proteomes:UP000094801};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          5..319
FT                   /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT                   N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21505"
FT   DOMAIN          767..929
FT                   /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18004"
FT   REGION          824..873
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        824..855
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   963 AA;  107660 MW;  27956C519BD91B14 CRC64;
     MAAITSAAPY LSLLEEHDPT LKSYALKSLN ELVDQLWAEI ANNITNIEEL YEDKQFSSRK
     LAALLASKVY YNLGDYDSSV KYSLLSGDEF NVNENSEFVE TIVSKCIESY IKLSQLKYDD
     DSIIIDDQLT SIFEQMLNKC VKQGEYKISL GISLESYRLD IVKDIIQQLL KDSSSNEEQV
     MGLINYVLTC TTTVIENIKF RSECLNAFIL ILLSLKNPDY FIITKIIVQL NDYNLAHKVF
     KDLIIQSNDE GDENSILIAY QIAFDLVSVA SQELLTKSIS ILDSDNSLNK FDIKIIRLKK
     ILSGVPTCDF DITFLSNNNH TDISILNNSK KVLDGRSSIF HSAVTFQNAF MHVGTTDDSF
     FRSNLEWLGK ANNWSKFSAT AALGVIHKGN LSQGNSVLQP YLPGSTSSPY TNGGSLYGLG
     LIYAGHGSEV IEFLRKQIVD NSNQSDDKKT DIILHGACLG VGVAAMALCD EEIYEELKTI
     LYTDSAISGE SAAYSMGLVM LGSGNESALD DMLTYAQETQ HEKIVRALSI GIALICYGKE
     FQADSIIEKL IQHQDSNLRY GGCFTLALAY CGTSNNLAIK KLLHVAVSDS NDNVRRVAVM
     CLGFILLRDY TTVPTIVELL SESHNPHVRY GTAMALGISC AGRGLQAAID VLEPLTKDSV
     DFVRQGATIA KSMILIQQNE KTFPKIKDFK EQLAKTVSNK HEDSLAKFGA ALAQGIIDAG
     GRNVTIQLEN TLTNTLNMKA IVGLTLFTQN WYWYPLTHFL SLSFSPTSII GIREDLKIPK
     FKINCHTSPE LFSYPPKIEQ QVEKQIEKLS TFVLSTTVRA KARAAKKDKA KKEEDKMDID
     DDEASTQDKK ETTESKSSNT NNSSELSDEE ESKKYVKQPY QFENMTRVVP FQLKHVSFIK
     NDRFIPIRRF RGMSGIVILK DTKPTESIDR IKTIREKYNT EAPIPDPFKI DAELDKELFE
     DDN
//