ID   A0A1E4SV62_9ASCO        Unreviewed;      1276 AA.
AC   A0A1E4SV62;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=DUF726-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CANARDRAFT_30023 {ECO:0000313|EMBL:ODV83400.1};
OS   [Candida] arabinofermentans NRRL YB-2248.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Ogataea; Ogataea/Candida clade.
OX   NCBI_TaxID=983967 {ECO:0000313|EMBL:ODV83400.1, ECO:0000313|Proteomes:UP000094801};
RN   [1] {ECO:0000313|Proteomes:UP000094801}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL YB-2248 {ECO:0000313|Proteomes:UP000094801};
RG   DOE Joint Genome Institute;
RA   Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA   Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA   Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA   Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA   Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA   Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA   Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT   "Comparative genomics of biotechnologically important yeasts.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TMCO4 family.
CC       {ECO:0000256|ARBA:ARBA00009824}.
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DR   EMBL; KV453864; ODV83400.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1E4SV62; -.
DR   OrthoDB; 8526at2759; -.
DR   Proteomes; UP000094801; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR007941; DUF726.
DR   PANTHER; PTHR17920:SF24; LIPASE MIL1-RELATED; 1.
DR   PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR   Pfam; PF05277; DUF726; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000094801};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        533..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        573..593
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          266..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          935..969
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1000..1221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..302
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1060..1196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1200..1221
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1276 AA;  142786 MW;  5A00393A98C2483B CRC64;
     MSSSNVNSPN IEALRKRDSI ISTKLALSST TDLSIPNADL IHSQYNNNNS SDSDLSDTDD
     FVEFQLGSKT KDTKINETVT IMNRNLSRVK KDSIMDQLRK SASQEQIIEN DESGQRDYNN
     STINKLDVVD MNRRLPSKNS SIDDSDDEDW KEMDTQLNYT DIYNIKGDKI QSFIHSSDTI
     TNQNKAQDVD SPVQSSTNLF DTIKWSKKNE QTIHNNNNNN GAGDIEDSAT LGYTRIAAEE
     QATKFNDMDQ KFDYLFVNED SNLRKLHHSN GSRGSGDGSD LQNTTFENDK QQQQQEDQKN
     IEMNPDSQLA TTRSMLQEPQ KIAYAALIKL IIVRMHTQLT EIRGSGSISI MKKLAIAQKS
     YTRWSMNVMN QLYDHLGVKE GKEREMIENL SCHGVETKDL VSWLDINLTI SNPLKKQIQT
     DNDNDNDEEI KVIGVDNENE TLEIDVRWTL ICDLFLILLE SSIYDARSRT LLLSFADAIG
     IKNLEVYQFE RRITDALEMD GTLAMMNNSQ TWDEKDILKE HSKKFKKQKY VKIAFATVAG
     GLVIGLSAGV LAPVIGAGIA AGLTTIGIGG TSGFLAGAAS TSIITTTGAL AGMRVGSKGM
     SRRAGSVQTF EFKPLHNTGR VNLILTVSGW MSGKMDDIRL PFSTVDPVMG DLYSLLWEPE
     MLTSMGQTIS ILASEVLTQS IQQILGSTVL IALMSAVQLP MMLTKLGYLL DNPWNVSLDR
     AWSAGLVLAD TLRRGKLGIR PITLVGFSLG ARLIYSCLLD LAKTGDYGLV ENVFLFGSPY
     VIKADQIAMA RSVVGGRYVN GYSKKDWILG YLYRATSGGL STVAGLSEVE GMENFNCSEY
     IQGHMEYRKV MPKLLMELGW EVLNEDFIEI EQPDPEQTER QRKLIHDFEE ASKQLDKNKK
     DKNNNKKKKK TWYNKWFSKQ NKEWWEMYEE GINEQHEKEG EGEGEGDKSK ENESESDSTA
     KDEDHDDVNT LFDLNQLQKE VENIEVEAAN LKEFKLKSPN VSKSENFESI PKTPKVSMNE
     DEFITDDNIT PEQSKGDTDT DIGIGIGIED GKRKSATNVK RRSASNSLFN ISVVQSPTKK
     ETEPQMRSFR ITSNSNEGKG TQQQQQQQRS SSFNFNVIQT SNSTSLIPSQ ASKSDDSSNG
     AALQPSQASK SDDFSNNAAL QPSQASKSDD FSNNAPQPSQ ASKIAQTKNI LNKSIEEKSI
     PPTVESEERT VNNHDDTYGE DDINMEENIK ITYDDEFEML NDKITKDNES SVSQELDYGD
     DDEFPTDERN IEITFS
//