ID   A0A1E4T2X2_9ASCO        Unreviewed;      1326 AA.
AC   A0A1E4T2X2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=5-oxoprolinase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CANARDRAFT_7461 {ECO:0000313|EMBL:ODV86105.1};
OS   [Candida] arabinofermentans NRRL YB-2248.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Ogataea; Ogataea/Candida clade.
OX   NCBI_TaxID=983967 {ECO:0000313|EMBL:ODV86105.1, ECO:0000313|Proteomes:UP000094801};
RN   [1] {ECO:0000313|Proteomes:UP000094801}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL YB-2248 {ECO:0000313|Proteomes:UP000094801};
RG   DOE Joint Genome Institute;
RA   Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA   Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA   Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA   Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA   Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA   Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA   Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT   "Comparative genomics of biotechnologically important yeasts.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   EMBL; KV453851; ODV86105.1; -; Genomic_DNA.
DR   STRING; 983967.A0A1E4T2X2; -.
DR   OrthoDB; 674at2759; -.
DR   Proteomes; UP000094801; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000094801}.
FT   DOMAIN          6..219
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          239..543
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          560..738
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          759..1293
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
FT   REGION          1303..1326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1308..1326
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1326 AA;  142611 MW;  CC79C4A7B5937EFD CRC64;
     MTGITIAIDR GGTFTDCVGN PGTSKQEDDV IIKLLSVDPQ NYADSNLEGI RRLLEIFAGE
     KIPRGQPLDT SKIESLRLGT TVATNALLER KGERCALITT KGFKDILKIG NQSRPRIFDL
     SISKPDELYE TVVEIDERVT LEDYVEDPKS HFTEPNGKDL VKGLSAETVR ILKAPNEEEI
     RSLLTILYAS GIRSIAVCLM HSYTFPDHEK IVGKIAAEIG FTHISLSSEL SPMIKLVARA
     NSSVADAYLT PEIKKYLKGF ESGLKDGLAS VATGKTTGVK CQFMQSDGGL VDASSFSGLR
     AILSGPAGGV VGYSKTCYDP KNNIPLVGFD MGGTSTDVSR FGDGKFDHVF ETTTAGVTIQ
     SPQLDINTVA AGGGSILSYK NGLMMCGPES ASSHPGPACY RKGGPLTVTD ANLVLGRLVP
     EYFPKIFGPN EDQSLDTQAA LDKFEALTKE INDANPKLDD MSVLEVAHGF LMVANETMSR
     PIRQLTEARG HVLSQHRLVS FGGAGGQCAA DVAGLLGIDT ILIHRYSSVL SAYGMSLADV
     VKEVQEPSSY LLSAETQPLL EDRLNALKAS ATESLVAQGF QVKDIVFEEY LNLRYQGTES
     GIMVSKGSES WDFKERFYDF HKREFGFVFD KNIIVDDIRV RAIGKGLSIE EEGIDEQIES
     LTTSGQIKAV TKDKIKLLKN SFWGDAGSLE TPIYRLEELE IGAQISGPAI IADGTQTNVI
     PPHGTALVLK THVVISLNAN TKTSTTETKT ADGEILIEPV LLSIFGHRFM DIAEQMGISL
     QKTSVSVNVK ERLDFSCALF DPEGNLVANA PHLPVHLGSM STCIATQAGI WKGKLKPGDV
     IVSNHPSAGG THLPDITVIT PAFDGDKIIF YVASRAHHAD IGGLLPGSMP PNSTELWQEG
     AAIYSELLVK NGEFQEEKIT KILLDDPAKY PGCSGTRRLS DNISDLKAQI AANQKGISLI
     GQLVDEFGLP TIISYMTAIQ DNAAATVTDM LEKLISNYGI ENLKCTDFMD DGSQISLQVK
     RDPDDNGIVF DFEGTSPQPY NNFNAPRAIT YSAIIYCLRC LVDEDIPLNQ GCLRPIKVKF
     PQGSILWPDN ACAVVGGNVC TSQRVTDTIL KAFNVMADSQ GCCNNLTFGT GGNNDDGTYV
     QGFGYYETIA GGHGAAAGWK GVSGVHTNMT NTRITDAEIF ERRYPIILRE FSIRSGSGGK
     GMNDGGDGVI RDVEFRVPVT ASILSERRVI APHGLNGGGD GQRGLNLWIR HVLNEDGEIV
     GQKTISMGGR GTVSCAAGER VVIMTPGGGA YGKVGDKPAV DVGKKSHPVS SGTGSVSLRN
     QIQIEN
//