ID A0A1E4T362_9ASCO Unreviewed; 1021 AA.
AC A0A1E4T362;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Vacuolar protein sorting-associated protein 41 {ECO:0000256|PIRNR:PIRNR028921};
GN ORFNames=CANARDRAFT_27425 {ECO:0000313|EMBL:ODV86162.1};
OS [Candida] arabinofermentans NRRL YB-2248.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea; Ogataea/Candida clade.
OX NCBI_TaxID=983967 {ECO:0000313|EMBL:ODV86162.1, ECO:0000313|Proteomes:UP000094801};
RN [1] {ECO:0000313|Proteomes:UP000094801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL YB-2248 {ECO:0000313|Proteomes:UP000094801};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for vacuolar assembly and vacuolar traffic.
CC {ECO:0000256|PIRNR:PIRNR028921}.
CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000256|PIRNR:PIRNR028921}.
CC -!- SIMILARITY: Belongs to the VPS41 family.
CC {ECO:0000256|ARBA:ARBA00009582, ECO:0000256|PIRNR:PIRNR028921}.
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DR EMBL; KV453850; ODV86162.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E4T362; -.
DR STRING; 983967.A0A1E4T362; -.
DR OrthoDB; 8838at2759; -.
DR Proteomes; UP000094801; Unassembled WGS sequence.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0030897; C:HOPS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-UniRule.
DR GO; GO:0034058; P:endosomal vesicle fusion; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR016902; VPS41.
DR InterPro; IPR045111; Vps41/Vps8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR PANTHER; PTHR12616:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF00400; WD40; 1.
DR PIRSF; PIRSF028921; VPS41; 1.
DR SMART; SM00299; CLH; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR028921};
KW Reference proteome {ECO:0000313|Proteomes:UP000094801};
KW Transport {ECO:0000256|PIRNR:PIRNR028921};
KW Vacuole {ECO:0000256|PIRNR:PIRNR028921}.
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 116568 MW; 5075C45AAB55C3A1 CRC64;
MVPKNRRRSS ENSSTSADTH QNHAYTDEIV DTTFDYDSTI DSISDSSITM DRQETPTPDG
DILNSTEEHT TPRESVNDLQ SSVAAIEDKA RGEQPAEASN GQHGNDDDLD GDETEVEDED
QEPPKLKYTR LSKLPARFFN KDPVSCCFFH EQVFIFATHS GFIHLCKPDF TPIRTLKAHK
TSVLSLHTDG EYFASGSIDG TIVIGSITDD KDITAFDFKR PIHAVVLDKQ YRITKSFISG
GTSGNVVHST RNWLNQRQDT ILDSDNGPIT MIKTIDDLIF WSNDSGISVG QISARAKIHH
EPLPKDFPRA EIYWPKVHYS DRDRIVIGWV NHVWFFRVSV SLDPNSTHVS KILSSAASSF
RTPIDKKIDV ENHIILEDTL IAGISEFNDD LMVLNYVPPL RISNSGNKSK DFEPQPPELK
IINKVTLEEE SVDEVGLNNH VSLGLNDYHL SQYISVEGGA KWFLISANDG VIVQEFNLHD
QLTWYNAKGR YLEAWKMCEF WLDKVERMNI GLRQVDSYVG EDNWKAAGDF LADVLRVGEG
KYSDSYIQRV TDEWNNWIAT FVMANKRNEI VDAIPVSYIY GEEFTLKEDT YDGFLDYYFS
KDNFSKVIEL VNKWDHMLFN VSDVAARIQD ELKHYDNNAT KSDDEVVLLT ELRKLYVELC
TELDEPELCV DHMIILKDEN TMQFLDEHHL IMRCLEKLPS IIHISLGDKD VKDYTVNDLK
EKLYVCIQIL VENSHEVLPH TIIEVMDGAD LDIFSYLYLE ELSLMDKMLV KDFEDEMVKL
YASYNTKSLL TFLTKHNNYS IENAIGICQE KSCISELVYL LSKVGENKKA LKLIVDDLKN
PQRAISFVSS VNDKELWDFL LDYSMDRPEF IKALMVASGD LIDPIPVISR IPKQVEIQGL
KDALLNITTN IELDHTIYEM ILKIISNETM ALTTLYRNSI SKGYSFNPNC HKKLLTDTLI
KFSDESKPLI TEEELLGGPD EVWKFTAVTH TNKITHMSFI KRQLMMLKMK MNGTNGTNGN
F
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