ID A0A1E4T3B4_9ASCO Unreviewed; 2088 AA.
AC A0A1E4T3B4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CANARDRAFT_27421 {ECO:0000313|EMBL:ODV86158.1};
OS [Candida] arabinofermentans NRRL YB-2248.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea; Ogataea/Candida clade.
OX NCBI_TaxID=983967 {ECO:0000313|EMBL:ODV86158.1, ECO:0000313|Proteomes:UP000094801};
RN [1] {ECO:0000313|Proteomes:UP000094801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL YB-2248 {ECO:0000313|Proteomes:UP000094801};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KV453850; ODV86158.1; -; Genomic_DNA.
DR STRING; 983967.A0A1E4T3B4; -.
DR OrthoDB; 1359393at2759; -.
DR Proteomes; UP000094801; Unassembled WGS sequence.
DR GO; GO:0005933; C:cellular bud; IEA:UniProt.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF96; GTPASE-ACTIVATING PROTEIN BEM2_IPL2; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 3.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000094801}.
FT DOMAIN 536..804
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 1020..1204
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1839..1873
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1893..2081
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1714..1739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1716..1732
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2088 AA; 237278 MW; 9D05A2F6F888CFD8 CRC64;
MKKFLGRKDK RRSLASSSSS SSISSLAVDR GAREAYSQLQ QQQQPPSQYS KSHERSSLAE
VDEESEIHSL VTTVSRSEEL LPEEIEAEAR LLSKNNKNTG SDALLIQNQK KSQQHTLERR
KSTSILKSLS SKRSTQNLHQ SHPRNVNSAK SVSNGSQSLV DVLFDHELEK VSWLNRFNED
TAEEFKLCRA ELKGSTLSIY KPPVEMSDIK CFRHGDKYDQ FVSSDDNELR PQTTNTTMMT
GITASSTIAP QDEKSKQVQQ KQQQQHDIES LADAFKTING SSSSLLGEDD SSSIQTGSTK
EQLDQNLEST TTALSDDVRS LRSKKSMPMA NMALGSQLSL ATSATAETSS SIKLSYSSTH
FPHPDLVIDS STGMITNGTL ESICHAIVFN PYHQFAKSLL KVLPLLDDMS TALAYFSKFC
EQFVQVNGDT KQYKYTDDEK GPVLVTNYVD SNMSKRLIMI VEEIKNNFSG MLLDDEILKS
VWKLILTIDP HHNCDELKKT VHQKQQNLSY LVNFESPDGT PPSLDQFSAE QFMNCDLSEL
AREITKINLS FTNVWDAKTD PSLLYEITQQ NYQYWRKNPL IFNTSKNIHY LGRLLSYHLF
EDPAYSSTPT SRGMILTRWI QLGTHLDKMG DMVSWLAIST TVCSMPILRL TKTWNTIMPN
LIKLVSTNWA PVVFELDRRS MVSFASHRSS YHVLAPQGIG KTYPKENVVP YFGDLFIKKS
QPMLKVIRQC QRHLDRVSAS FKKWDEYLDL ITNDESLTMT SDDLKSGGSP ELKAKLHVLL
SYHSKGDPLT SSDIMDLSLI VEPSYTGQYH NYHDESRSPL FLGSYASILF PQVLDVYRIY
DQRSLIGAIG GGELARNVLA NTLTQKEGSN RAGRSQFVKN VRDLFNIDSF EYHVDKSIIF
KSITYLDDVA DIEKQQRKQQ QKNSRKSITR SRPSSVLFSE NANIKRFSSY SSSSFNLEDY
VTAYQSYLKE NPATSIANAT TTTPPSAPAA TVASLSVAEE DETKGLIEPV ASVSSSEMTV
EILTKSATLD RLIDLLVLTS SLFGSRINES DIKKAASSKE SSDSRVSLKM DNGVFTMTFF
ATYRGFCSTK TLLEGLTRRF VGSKSAAISI VNELQNKSEN QSGKKFPDWD SPSLGKYSEV
NWKYVAQIQL GILETLLILV SDYYHYFTDD LENKVVFDNL LRITDNETIV QWAKVLKWLE
ADDSKDDDGE FYRQVKELYD EIVTIYKKMR KIYVKKCYKP QIKISGSELL LSSSALDFTS
DISVIPADRL LPKLHDLKGI QTWISQFDKT VESIYKNIEV KDWIDTFEIL EVQTAKSPMS
LFQYDAQKLK THEDLLIISN VYSWLSTLLD SDPEAVDTSS KKTTTENEKD SFFVNMFPNS
VKSTFQFYFK FKSYLIHQIA DTSISFAERS ERMAVILLMV QICRIRMKQI SLFDNDDMDA
DVEVDVKVDV DESKAEDKSS ELGDETPVKE ATIEETIEEE VVSLRVSSLI ESCLVDTILS
PESRFFAYAW VNASKLLKNM LDVKEEEVPI SHYRNLTQLL PTEEAVETKI LAESNVQQLS
PCPGWIVERL LEISCFIPNM SVENTNLINF DKRRFAYNCI SNIVDMVPRT TNETLPRNSD
FGFLLDFRID IVDSKSVYEF ASKENKENGA VSRAKIFKDH IDEQIQLLKL EYYKKQALAK
REYDRLGKSR QYISTAGSTA SAVSSLRSAP QNKFHRRALL SDRERERDRQ MSLRSIPSYA
SSTSLSTQST AVASTNSASS SRFKLTGLFN KASRPFSMTM NGFNQQIPER TILVRDLPDA
DVFIDSNTGQ VYTTRAKPVL VMNLRDFTIF PIYRTPCGFK LSSSSNPSLE YSFQSTTEKE
KDDWIYRLNY AKKHWYMSKQ ANKNNSTSLV YGVPLEYVCI RESRTIPNVI EKLMSEIEYR
GLEEVGIYRK SASLSVLNQI KDQINAKGDF NMEHQLVFDV HNLTGCIKLY LRELPEPLIN
DEVIPEFEQI RDLVKSEERF PIYKTILSKM PTFNFYLLQR LIRHLKLVDE NSDLNKMNAS
NLATVLGGSF IEGCKPENMR RSFGFMNFIC EDMILNYEKI FTSVITEE
//