ID A0A1E4T4A4_9ASCO Unreviewed; 1119 AA.
AC A0A1E4T4A4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752};
DE EC=3.2.1.24 {ECO:0000256|ARBA:ARBA00012752};
GN ORFNames=CANARDRAFT_174676 {ECO:0000313|EMBL:ODV86597.1};
OS [Candida] arabinofermentans NRRL YB-2248.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea; Ogataea/Candida clade.
OX NCBI_TaxID=983967 {ECO:0000313|EMBL:ODV86597.1, ECO:0000313|Proteomes:UP000094801};
RN [1] {ECO:0000313|Proteomes:UP000094801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL YB-2248 {ECO:0000313|Proteomes:UP000094801};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; KV453849; ODV86597.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E4T4A4; -.
DR STRING; 983967.A0A1E4T4A4; -.
DR OrthoDB; 2786490at2759; -.
DR Proteomes; UP000094801; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ODV86597.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000094801}.
FT DOMAIN 554..633
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1119 AA; 127130 MW; CA5D64C37F64297C CRC64;
MGSKYPQLNN NPQFKPVDSI YEGRLRQFIN TGGGYQGLML PKFYVKRRFD NSKPATGSDE
PNAGYIDLKH WPAPELTKPL FHEVIPDKLP DFKTVHKGDN FGPAWSSHWF QATVKIPDSW
VDERHVLMNW DSGCEGMVFD EDGLPIQGLT GSSERTEFII PPEWFGKGTG EFIFYIEIGC
NGMFGSTQSS YRLDSADIFV PNYDARGLYY DFWIISDAAR ELNGPQKHKA REVANRIMDT
FDEIDESTIL KCREIAKEYL GDNIDSEKVF EEAKVNPSSN VYAVGNCHID TAWLWDFATS
KTKVARSWSS QIRLIERYPE YVFVASAAQH FKWLIDYYPD LFEKVKQFVM QGRFVPLGGS
WVENDTNMPS GEGFVRQFLM GQRWFENMFG FKSDIYWLPD SFGYSSQVPQ LCRLAEMPNF
LTQKLSWNNI NQFPNNTFNW VGIDSSQVLV HMPPDNTYTA PANFGDVKRS IQGHKNLYND
QKGLLLYGKG DGGGGPTDEM IEKLRRCRGL ADTVGGEMPT VQMNCTISDF YHDIRKDTKN
GATLPAWKGE LYLEYHRGTY TSQAKVKNFM RTSEMLMRDL EFLATKASVE LPDYNYPHAK
IDRLWQDICL CQFHDVLPGS CIEKVYRDDV WPMLSKVIET EYKMIKEILS LFEISELQTD
NEIKSDDNIV KFNSFPWKRF EIVKLESQVA SDCALATQSG KYVAMESESD NTTSIMRPLV
GIKSASDIKH PASIEKVNDD LYVLKNDKLK ASINSNGVIV SLLDVINGRE IIDSSRLKGG
NQYVMFADTP LNFPAWDTEL FSLGKYKNID SATNIEIIEN GPLLSALKVV HKLSATSEIT
TTISLEGLND LSQKSMLKFD CHVEWHEIYK FLKVQFPVTI NSETANYETQ FGITKRPTHF
NTSWDVAKFE VCSHKFMDYS DFNYGVTILN NNKYGGSVHG NTMTLSLLRA PKYPDGNADM
GSHDFSYALM PHQGNLGVES VRAGWEFNDR IPGVYLQKKK IASSKSEELV SIVGDANLML
SNVKRGEDDD TAIDSDGMQL DDLPKKFKGH KTLVLRVYES LGGFSKATIK IGQPVKQVFK
TNLLEEEKEE VKLLDGKNGF EIVSRGFEIS TYKVILDKV
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