ID A0A1E4T5N4_9ASCO Unreviewed; 1049 AA.
AC A0A1E4T5N4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=CANARDRAFT_196247 {ECO:0000313|EMBL:ODV86978.1};
OS [Candida] arabinofermentans NRRL YB-2248.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea; Ogataea/Candida clade.
OX NCBI_TaxID=983967 {ECO:0000313|EMBL:ODV86978.1, ECO:0000313|Proteomes:UP000094801};
RN [1] {ECO:0000313|Proteomes:UP000094801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL YB-2248 {ECO:0000313|Proteomes:UP000094801};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KV453849; ODV86978.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E4T5N4; -.
DR STRING; 983967.A0A1E4T5N4; -.
DR OrthoDB; 1630at2759; -.
DR Proteomes; UP000094801; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 3.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000094801};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 600..916
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 919..1049
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 517..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1049 AA; 117799 MW; 411E813F02E408AE CRC64;
MLSRSLDTFE VTNLLLSSDI EGNLHALNRN TGELVWTLLG NDPLVSIVSD EEESRGISTT
ETMSTQMVWM IEPFADGSIY YFTEQDGLQK LPTSIKQLVQ KSPFSVGDDF MYTGIKRSGI
VKIDARTGEL IESFGLPNSL LDEGTTASSY PIEDESSGSD VPTILLGKTT YELSIHSKNG
TSWNITYSSW GPNNLHAKLV EQNFESIDNL YIQPFHDNSL LALDAETKSV KWVSSLPFVT
VNVFDVFLDR DDYEDHQSQF IVIPHPLNSR PALPNSFSSS SDSKSTFIDR TNEGSWFAMS
EYNYPSLVKS APLAKYITQK RWRSSQVLQN PELLAMSISG VHDGSLKLQL DEQREKERLS
GGVGKNSINS GRLGLPEADS SEQHYLIDSQ YPPYGDIGDP TSTSKVAPLT KLIFRAFENV
LVTILGIAIV AIMSRLGLVP PLTQILSRFG LFKRTQSAVE LVDLLLKDDV VELEKSFDLI
KKERFGGDYQ KRNKEGQTGN GFSSSVADDQ KLIEEDLLMN SQQQPKKRKR GSRGGKKNKK
KDSTVITNAD ENNVDMTYTT TTTTTNNNHE PVVMTLSQIQ TAPSQPQIIT STTVANNSLS
ISNDVLGYGS HGTVVFKGSF EKRPVAVKRM LIDFYDVASH EINLLQESDD HPNVVRYFCS
QQSDRFLYIA LELCEASLED VVENKKENCA LISKNMDPIN VLLQIANGLN HLHSLKIVHR
DIKPQNILVV PPKKLKGSKS SSDLTNTAEL ESERIADNES PIRLLISDFG LCKKLEHDQS
SFRATTAQAA GTAGWRAPEL LIDDVDANSL TSETNNTHSS SIGENSDPLI SNNRRLTRSI
DIFSAGCVFY YVLTSGAHPF GDRYLREGNI IKGDYNLDLL DSLRDRFEAK DLVESMIAMD
PNARPDMALI LKHPYFWSIE KKLEFLLRVS DRFEVERRDP PSAMLLTLEA IATNVLGEEG
WFVKFDPLFM DNLGKYRKYN TNKLMDLLRA MRNKYHHYQD MPAALAKSMS PLPDGFYWYF
VGKFPNMLMQ IYKLVESNLK NEETFRSFF
//
