ID A0A1E4TAB9_9ASCO Unreviewed; 3771 AA.
AC A0A1E4TAB9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CANCADRAFT_52791 {ECO:0000313|EMBL:ODV88694.1};
OS Tortispora caseinolytica NRRL Y-17796.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Trigonopsidaceae; Tortispora.
OX NCBI_TaxID=767744 {ECO:0000313|EMBL:ODV88694.1, ECO:0000313|Proteomes:UP000095023};
RN [1] {ECO:0000313|Proteomes:UP000095023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-17796 {ECO:0000313|Proteomes:UP000095023};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Jeffries T.W., Grigoriev I.V.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KV453843; ODV88694.1; -; Genomic_DNA.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000095023; Unassembled WGS sequence.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0004672; F:protein kinase activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:UniProt.
DR GO; GO:0019219; P:regulation of nucleobase-containing compound metabolic process; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 4.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000095023}.
FT DOMAIN 2619..3175
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3416..3741
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 483..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2012..2036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3184..3240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3208..3240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3771 AA; 430316 MW; 26E4EEBD79C8957B CRC64;
MAAVTIDSIK SLTDRITDPK HELRTRLAAI MELKEISDKI LPSPDYAQIV PLLVPALCST
LDSTPPSFNA ATLEQRFKNT TILVLYRLPM DDNLQPFIPE LINVLTNVIK TDNEENGTLS
IKFLSSIFRS YKNAITDKVQ PFLDLVCNIY RNMPAVVRES FELSSAATAT PGTAPAATSP
ESAVNTFSSP WTASSPGISS DVIEGSIGRP LAKAMYSFKV LTECPIIVVM LFTAHKEFIE
PNLTVFIEQV IQMLRLEAPA QAEARPNAEA HNELYTIVSP AIKNRHLFGE FITAQVKTMS
FLAYALRTFS SSLENYHKEI PEFVVRLLQD CPRELSASRK ELLVATRHFL STDVRTAFIP
KIDILLERNV LVGDGLTVYE TLRPLAYSMV ADLIHHVRNE LSVKQIWKAV RVYCANMQDM
SLSNSFHIMS AKLLLNLVER IMQLQDNLEG RQLLITIISA FADKFAQLNM CYPHALASAY
KDTKSDDKSA SDEMQVDTET NSNTPLDFFD TNQAFPIKIG TEPRIDGLKD GKNLFKGLMT
FLRTSMFGLK NCNPPPPATD KSDLQWNDCV RGLTYDEVLM FRKLFREGIK CFSYFSSPKS
AAVNEQNSAK LESSLNSKEE RENMEFFATV FIHIDPPSFN EILEAEMENL YTAIAENSTL
LYLPQFFLSS EATSTNCVII LMDFLVKNLE NLGKSDSAQT SVMMRLFKLS FMAVNLFPTA
NEDSLLPYLQ KLIVSCMKLS TSAEEPLNYF ILLRTLFRSI GGGRFEKLYK EVLPLLQTLL
DSLNNLLLSS RIPQARDLYV ELCLTVPVRL SVLVPHLSYL MLPLVIALRD SPELVSQGLR
TLELCVDNLT AEYFDPILEP YISDVMAALW SHLRPLPYSH VHAHTALRIL GKLGGRNRRF
LQPPDDFEFR RYLKEDPAIY FKLNGIKEAQ KFEFVVPVAK HAIQLLDNPR LDSRYHSYAF
KYLAEVSKML FRSARIPEGY ESTMHNVIQL SLMENPPKFT LNDEITDPDE KLSSINYLEA
CVDQENKFMQ SVIEALFSTA HLPDVKNEAV SLLKNIAEHV ILLEFDKVPR TILARTVVDF
NIDKDLRVPH LDLIEGFLIS LAHAMSSWRV ETVDIAKEVE NHMLDTLQKF FKNTADLLNF
VGVLDMISAF CHTCHNSLWY VKHGGVIALT IIFDRCDENN KASLAWFHKR LFEIVRALLF
VLKDISAETP TFVSAAAKEL LLKILKQYCS QLTDDEVTLK KFQQLCGILA YDLVNPSELV
RQSIKDAFVA ISEITGKPQT ELLYPVKATF LQPIFGKPLR ALPFPNQVGN IDAVVFCMSL
SEDFLEFNDE LKRLIAEVMA IADADDESLA STQKVDEYRT SIQLVQLRIR CIKLLSLVIN
SQYFITSDEE QKQEKGQARA RILAIFFKTL YLKDSEIVDA AHECLADYLA QNNKLPRDIL
QIGLKPILMN ISDHTRLTVS GLEGLGRLLE LLTKYFKVEI GHKLFDHLKT LSDPASLLAA
SSRVLWSQQK IKIMAAIYAV YHCLPAAASI FLNDLATTLL QLESQLHVSI MSPFRKPLAL
FTNRHHDESA AYFAARIKEG PMSHLFIGLL KEKCSTELRT VVTTKLNEII DESIYTEENL
EARSIGICNL IEIVSILSSY HSEFIKKNHN LFPKLIAMFA DLHTVINTTW LTSPVHLKSK
RAQSLLEELM RDYFTEFPTD SDTLYALIEH VVNEDISSVN TLHMMIFDLI VSNNDPVIRG
SYLDSALKFA STASIAGKVY VFKYIINMIL MKEAASRNDL TGLVEKASPN IGSKPNWLEQ
VFMRVWKNSS LDSLDEASGV IDKYRFQLLQ LTCILIKYGA PLVNDIRKDI IKFLWGCGRI
EDILSKHANH LVIVHFIDAF ETPAKMVTQV YVSLLKSQQS EARMLVRESL DVLSVQLANR
IGPSKWAKWV YRVLQEELQH ASQVVNIFYF ISTKRDMFYP HRSMFAAAMV SAIPKLAFSG
SSPVDHASDN LVLAIDLADT IFEWIQRQKS ETSDTESTEI QAPRRSKRKH GEVIKEGDED
VEPIVSEPIE LSLNAKESLV SCLIRLICMH PKKVSDNELY RKIIKVLSGL LGPDVWPDVT
NAIQLDVFER TIALNDADER SVNITINTLE VIHVVLENKP KEWVDRSYET FIKLLDQAIK
CDSLVVHETL EKIIDFLLNH ISATYAETEG DEENSMPDGP EQFVQLITQT IQDKLTTAVS
ASKSYGAGVI LASSLVKFLP HRSDSLLPLF MKAFGRLCRE HIMLMQQKSQ QAASARNGSQ
SPENPIDTIQ FEQTSSIIRD LIFRMLDIGK TRIAALGDQR RTFLSVLERL VEWSTDLQLC
QKLLKLVYSW IFEPKEVFPT IKEKTMLVAK MTIFEARDNA ELTEDFYDMV TSIFSHPQLL
KTDLVIRLEH SFLIGTRIEN FTVRKRLMNI LDESLNRNAW MRLWYVLKYQ NWESLSDSMW
LNQALQLIYG AISKEQNVQP EGNRLTARPI TSLFESIDEN DGMQIDLDED VSAAVATFLV
DRKAFIDSMS ILPIGSLLDS VVEMQYVAPE IVRLMWVNMF SVICSNISKR DLSELFQSLL
SLFSRDYHTR QADKNPNVVS IMLEGLHHVS DKLVLPPHLI KFLGKAYNGW YDAIGILEEY
PENSYTSDEK VREAALDALA ELYSSLEESD MFYGLWRRRC EYTETNVAIS HEQVSQWEKA
QQLYEAAQIK ARSGVLPYSE REYGLWEDHW ILCEQKLQQW DVLTEIAKHE NFTDLLLECA
WRMADWASDG EPLEQSIKTV MDIPTPRRQV FEAFMHLQKC LQKTESLSDL SKSCDEGIQL
SLRKWRTLPM RISDAHIPLL ETFQRYVELM EASQIYQNLH ATNVQNLESK TQELKGILQA
WRERLPNVWD DFNIWSDLVT WRQNVFSVIN KVYIPMVSAL QAAGVNSSSA NSYGYRGYHE
IAWIINRFAH VARLQDMSRV CIDQLTKIYT LPNIEIQEAF LKLREQAKCH YKNPQELNTG
LEVISNTNLA YFGAPQKAEF FTLKGMFLAK LQHSDEANQA YATAIQIDMN LPKAWAEWGR
FNDAKFKENP NDLSFVSSAI SCYLQAAGLY KSHKSRSLLG RVLWLLSLDD ANQTLASAFE
SYQGETPVWY WILFIPQLLT SLSHKEARIA RSLLIKIAKS YPQALHFQLR TTKDDYAVIQ
RQAMQAQNSK KNEKQATSAE TPKNDKETPN DGQSSASPPR DNIKVESSGS TTNDVTANPQ
SLNRQPWEYV DEIMGILKTA YPLLSLALET MIDQICQRFK CTPEEDAYRL IVALLNDGAQ
FMNRMAYQNE DTKLPPATEL NLTRIADSLL PPHIRKVFRE DFVNEKPTLK AYVAKMRKWR
DRWEERLDSR RSSVSLESLS PHLCEFHYQK FEEIDIPGQY LQLTQSNIHF AKIGRFLPDV
KLNRGFGICY KQISIQSHSG SVHTFTIQYP AARHCRREER VLQLAQTMNA TLEQKTESRR
RRLKFTIPAA IPLTPHIRII QDNPNNITMQ GIYEDWCKTR GQYKDEPIIF AMQKFQEAFD
ANHGKPDHGS LKFKILQTIQ ETLVPDHVLR DYFVSVYKSF EEFWLFRKQF SYQYAGVAFL
TFMLSINGRY PHKIVITRSS GSVWSSEMLP LLPSQNQFPQ FQNTERVPFR LTPNLQRLMG
DVSLEGLFSP CMMVISKCLT DEESDLEDFL SLFVRDEVIS WYTQQHRPAA QDQQLRDIVQ
MNVEKITKKA ASMSQPMSAK HPTNQAVINL IAQAVNPRDL ALADNLWLPY L
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