ID A0A1E4TD35_9ASCO Unreviewed; 561 AA.
AC A0A1E4TD35;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 22-FEB-2023, entry version 18.
DE RecName: Full=Nuclear protein localization protein 4 {ECO:0000256|ARBA:ARBA00019709};
GN ORFNames=CANCADRAFT_142508 {ECO:0000313|EMBL:ODV89671.1};
OS Tortispora caseinolytica NRRL Y-17796.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Trigonopsidaceae; Tortispora.
OX NCBI_TaxID=767744 {ECO:0000313|EMBL:ODV89671.1, ECO:0000313|Proteomes:UP000095023};
RN [1] {ECO:0000313|Proteomes:UP000095023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-17796 {ECO:0000313|Proteomes:UP000095023};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Jeffries T.W., Grigoriev I.V.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the import of nuclear-targeted proteins into the
CC nucleus and the export of poly(A) RNA out of the nucleus. Has a role in
CC the endoplasmic reticulum-associated degradation (ERAD) pathway.
CC {ECO:0000256|ARBA:ARBA00024703}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004335}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004335}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004335}.
CC -!- SIMILARITY: Belongs to the NPL4 family.
CC {ECO:0000256|ARBA:ARBA00011025}.
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DR EMBL; KV453843; ODV89671.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E4TD35; -.
DR OrthoDB; 5400828at2759; -.
DR Proteomes; UP000095023; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd08061; MPN_NPL4; 1.
DR CDD; cd17055; Ubl_AtNPL4_like; 1.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR016563; Npl4.
DR InterPro; IPR007717; NPL4_C.
DR InterPro; IPR024682; Npl4_Ub-like_dom.
DR InterPro; IPR007716; NPL4_Zn-bd_put.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12710; NUCLEAR PROTEIN LOCALIZATION 4; 1.
DR PANTHER; PTHR12710:SF0; NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG; 1.
DR Pfam; PF05021; NPL4; 1.
DR Pfam; PF11543; UN_NPL4; 1.
DR Pfam; PF05020; zf-NPL4; 1.
DR PIRSF; PIRSF010052; Polyub_prc_Npl4; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00023010};
KW Reference proteome {ECO:0000313|Proteomes:UP000095023};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 229..367
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
SQ SEQUENCE 561 AA; 61932 MW; 416DBAB136D257DE CRC64;
MILRFRGRDG TFRIDLPADA TISDVVQQLS LRIPSAQPST FTFSDAPNRP GQLATEVLSK
TVSDLGLKHG DLLFLAYDSA GTGDAATDTP DATNASARPA GPAAVSLSDL DKKLLAIDGR
IKRPRDPKFC KHAANGMCEY CSPLEPWDPA YIEEHKIKHL SFHTYLRQLQ HQQHSEVGST
VTKFLSQPFY GVKKPCPNKH APWPNGICSK CQPSAITLQQ QQFRMVDHVE FASPSIINRF
LDSWRSSGLQ RFGYMFGTLK PYTDVPLGIK AVVEVIYEPP QRDESDGLQL TLPWDDEDRI
NHIASECGLV PLGAIFTDLT DAGNGDGSVI CRRHANSYFL SSLEVCFAAE MQRRHRLKIP
FAENDEFSSR YVTCVISGNT KGEIEVSAYQ ASAAAESMLD VDLIEPSTDP GQMLVKLPQS
GSDRYVPDIF YRKVNKYGVG EQHSAKPAFP VEYLIVTLSH GFPSEPQPVF SGPGAFPVEN
RGYIGETADT ASVKKAVLNN ALNVSSVSDF HLLCYIQSMN ILDEEGFKLL VEFATTHEEN
VGLKLESNAS WQTFVMILES S
//
