ID   A0A1E4TE20_9ASCO        Unreviewed;      1127 AA.
AC   A0A1E4TE20;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE            EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN   ORFNames=CANCADRAFT_99732 {ECO:0000313|EMBL:ODV90022.1};
OS   Tortispora caseinolytica NRRL Y-17796.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Trigonopsidaceae; Tortispora.
OX   NCBI_TaxID=767744 {ECO:0000313|EMBL:ODV90022.1, ECO:0000313|Proteomes:UP000095023};
RN   [1] {ECO:0000313|Proteomes:UP000095023}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL Y-17796 {ECO:0000313|Proteomes:UP000095023};
RG   DOE Joint Genome Institute;
RA   Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA   Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA   Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA   Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA   Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA   Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA   Sun H., Kurtzman C.P., Blackwell M., Jeffries T.W., Grigoriev I.V.;
RT   "Comparative genomics of biotechnologically important yeasts.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC         and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC         residue protein attached to proteins as an intracellular targeting
CC         signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR   EMBL; KV453842; ODV90022.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1E4TE20; -.
DR   OrthoDB; 1423057at2759; -.
DR   Proteomes; UP000095023; Unassembled WGS sequence.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   CDD; cd02666; Peptidase_C19J; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR044635; UBP14-like.
DR   InterPro; IPR025305; UCH_repeat_domain.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   PANTHER; PTHR43982; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR   PANTHER; PTHR43982:SF6; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED; 1.
DR   Pfam; PF13446; RPT; 4.
DR   Pfam; PF00443; UCH; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095023}.
FT   DOMAIN          607..1117
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
FT   COILED          1016..1043
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1127 AA;  127473 MW;  E5B19976E5D96A03 CRC64;
     MPGFSLPALA TLVADYGISF PEIPDYQDPA AVQQFAAQHW KKRFLVTYKL YSSPNSYTLR
     SVCISTRELL YIYVSWDPSI YVPPDDDQSS SQIPPSLTDW FSTPALFNKT DSPPLLAHYV
     PEHLDIAEDS KANSPLDSAT FTAPDVTISF FLYPPRLSDS MLEQFSVESI RSRRESIIQN
     LSENDDPSKI PSFSPSRCTN NFGKLVLDTL SGSSRPINFE NPNVALSFTP SLASLIGFCP
     DGSGSSSRWV PPRTDSRSAQ VLREIATEAA IVGANSLNED ESIESYPSLM IPNDDAYDVL
     FNDMRIISYP IYSQGRGCPI TQKVLYYSLG CVSDFSDSLI SAYFDLQCIT DAKRRPYYFQ
     CLAEIAQYRT SDDLQMLIVQ LRSQGYTTLQ EMQGAYNRLN ITDDDIPTVD DDYIIQRYKS
     LLSSGNESDL MNCLKVLASL RESEKLLEFA NLSTMSVDVA YNVLEVSQDT TDGEILDKVL
     SMKETDQADT FATEQIEQAL KVIAIERKSP LLLDYYETSI LNIEDNDPTS DPYDLLGASK
     EMNEDNIIMI FQIRLEDSPE ELLSLRRMLR LIAIRSQSRL ISLYLKLGSL DAASTYLIAN
     CSEKVPAGIR NIGNTCYLNS LLQFYYTVIP LRKLVLEFDS NPDLHEDLNT RKRVGGRIVT
     SNEILRSQHF ITNLAELYKV MSESKGGSVE PKKELVYLTL VDPRNDVQLV DELVSSSSKN
     LEPASQSTSD INMDSDTDFV EDVQEVVPRK RSARRPSIKF DFQASIDAGQ QQDVAECIQN
     VLFQIEAAIK ADSFDDDGEQ IDVIKKLFFG KTKQIIDFES NSEVRYKTER FSNLIVDAAT
     GPRSLYDALD AYFDADVVSL DGGLARRYLT IQTLPEFVQI QIQRVQYDRI RGMPFKTTYH
     LGLFPEIYLD RYLDVEVKST LHFRENLWAK KRALSELRKR SEILGLKISS SQLSKVQPFH
     ATNPFANYGP SIATDKYPES LKSADILAKT TDWLQYSTTF PDADTDSLTL KLKAAQITLE
     DEYRNCQESI EKLEKELDEV LNDKEFQKHP YRLHSVFIHR GQATFGHYWI YIYDFENDIF
     RSYNDETVTT VADIQSAIYD DVAGNTATPY FVVYVRAAAA TELCGAF
//