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Database: UniProt
Entry: A0A1E4TGN6_9ASCO
LinkDB: A0A1E4TGN6_9ASCO
Original site: A0A1E4TGN6_9ASCO 
ID   A0A1E4TGN6_9ASCO        Unreviewed;      2111 AA.
AC   A0A1E4TGN6;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   31-JUL-2019, entry version 16.
DE   RecName: Full=Glutamine amidotransferase type-2 domain-containing protein {ECO:0000259|PROSITE:PS51278};
GN   ORFNames=CANCADRAFT_31714 {ECO:0000313|EMBL:ODV90873.1};
OS   Tortispora caseinolytica NRRL Y-17796.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Trigonopsidaceae; Tortispora.
OX   NCBI_TaxID=767744 {ECO:0000313|EMBL:ODV90873.1};
RN   [1] {ECO:0000313|EMBL:ODV90873.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NRRL Y-17796 {ECO:0000313|EMBL:ODV90873.1};
RX   PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA   Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T.,
RA   Goker M., Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H.,
RA   Aerts A.L., Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S.,
RA   Douglass A.P., Hanson S.J., Klenk H.P., LaButti K.M., Lapidus A.,
RA   Lindquist E.A., Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A.,
RA   Otillar R.P., Pangilinan J.L., Peng Y., Rokas A., Rosa C.A.,
RA   Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B., Sun H.,
RA   Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT   "Comparative genomics of biotechnologically important yeasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC   -!- COFACTOR:
CC       Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000187-2};
CC       Note=Binds 1 [3Fe-4S] cluster. {ECO:0000256|PIRSR:PIRSR000187-2};
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DR   EMBL; KV453842; ODV90873.1; -; Genomic_DNA.
DR   EnsemblFungi; ODV90873; ODV90873; CANCADRAFT_31714.
DR   OrthoDB; 126283at2759; -.
DR   GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016040; F:glutamate synthase (NADH) activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:InterPro.
DR   CDD; cd00982; gltB_C; 1.
DR   CDD; cd02808; GltS_FMN; 1.
DR   Gene3D; 1.10.1060.10; -; 1.
DR   Gene3D; 2.160.20.60; -; 1.
DR   Gene3D; 3.20.20.70; -; 2.
DR   Gene3D; 3.50.50.60; -; 2.
DR   Gene3D; 3.60.20.10; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR028261; DPD_II.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR017932; GATase_2_dom.
DR   InterPro; IPR002489; Glu_synth_asu_C.
DR   InterPro; IPR036485; Glu_synth_asu_C_sf.
DR   InterPro; IPR006982; Glu_synth_centr_N.
DR   InterPro; IPR012220; Glu_synth_euk.
DR   InterPro; IPR002932; Glu_synthdom.
DR   InterPro; IPR006005; Glut_synth_ssu1.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   Pfam; PF14691; Fer4_20; 1.
DR   Pfam; PF00310; GATase_2; 1.
DR   Pfam; PF04898; Glu_syn_central; 1.
DR   Pfam; PF01645; Glu_synthase; 1.
DR   Pfam; PF01493; GXGXG; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PIRSF; PIRSF000187; GOGAT; 1.
DR   SUPFAM; SSF46548; SSF46548; 1.
DR   SUPFAM; SSF56235; SSF56235; 1.
DR   SUPFAM; SSF69336; SSF69336; 1.
DR   TIGRFAMs; TIGR01317; GOGAT_sm_gam; 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
PE   4: Predicted;
KW   3Fe-4S {ECO:0000256|PIRSR:PIRSR000187-2};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Iron {ECO:0000256|PIRSR:PIRSR000187-2};
KW   Iron-sulfur {ECO:0000256|PIRSR:PIRSR000187-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000187-2}.
FT   DOMAIN       46    442       Glutamine amidotransferase type-2.
FT                                {ECO:0000259|PROSITE:PS51278}.
FT   COILED     1554   1585       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE     46     46       For GATase activity. {ECO:0000256|PIRSR:
FT                                PIRSR000187-1}.
FT   METAL      1172   1172       Iron-sulfur (3Fe-4S). {ECO:0000256|PIRSR:
FT                                PIRSR000187-2}.
FT   METAL      1178   1178       Iron-sulfur (3Fe-4S). {ECO:0000256|PIRSR:
FT                                PIRSR000187-2}.
FT   METAL      1183   1183       Iron-sulfur (3Fe-4S). {ECO:0000256|PIRSR:
FT                                PIRSR000187-2}.
SQ   SEQUENCE   2111 AA;  233482 MW;  3FC3D9FF7941500F CRC64;
     MDYDLENEDQ VRQVFDYQES PENQSWASAL PLKQGLYDPE YEKDACGVGF VCNIKGQASH
     KLISDAKNLL CNMTHRGAVG SDARDGDGAG VMSAIPHKFI EKEFARECGI SVPPLGQYAV
     GNLFFKPDEQ VLQDSIATFE RLSNSRGLKV LGWRKVPRDS SILGPAALSR EPAILQPLVV
     YDNETFDEKK FEIELYVLRK IATHTIGLHN WFYICSLSNR NIVYKGQLAP VQVYNYYYDL
     VNVDFEVHFA LVHSRFSTNT FPSWDRAQPL RWAAHNGEIN TLRGNKNWMR AREGVMQSSL
     FGEDLDSLYP IIEEGGSDSA AFDNVLELLT INGVLSLPEA VMLMVPEAWQ DNNLMDPNKK
     AFYEWAACLM EPWDGPALFT FADGRYCGAN LDRNGLRPCR FYVTSDDRMI CASEVGVINI
     DPTIVVQKGR LKPGRMLLVD TKEGRIVDDR ELKGKVANRF DFRSWTSGNL ITLPNVLDRL
     AANAGIECSL ETYQLDDTTV QRDPRLLAFG YTFEQISLLL APMAAEGKEA LGSMGNDGPL
     ACLAPQPRLL YEYFRQLFAQ VTNPPIDPIR ESVVMSLECY VGPQGNVLEM SPKQCNRLLV
     KSPLLTLEEF KAISNMSKVY PSWKVCTIDI TFPKEEGLNG YTAALDRICA EAMKAIDDSC
     KIIIISDRST GPSRVPVSAL IAVGAVHHHL VRNKQRSQVA LVVDTGEARE VHHLCVLVGY
     GADAVCPYLG LELLLKMNRE NLIAPKDAEP LSDHQVIDNY RHAVDGGILK VMSKMGISTL
     ASYKGAQIFE ILGIDNTVVD RCFAGTASRI KGITFDYIAQ DAFSFHERGW PNRQIVKPLG
     LPESGEYHYR DGGEAHVNTP VAIANMQDAV RNKNDKAWET YSKAEYEAIK NCTLRGLLDF
     DFDSCTPVPV EQVEPWTEIV RRFVTGAMSY GSISMESHST LAIAMNRLGG KSNTGEGGED
     PERSLRMANG DTMRSAIKQV ASGRFGVTSY YLADSDELQI KMAQGAKPGE GGELPGYKVT
     DQIAKTRHST PGVGLISPPP HHDIYSIEDL KQLIYDLKCA NPRARVSVKL VSEVGVGIVA
     SGVAKAKADH ILIAGHDGGT GASRWTGIKY AGLPWELGLA ETHQTLVLND LRGRVTVQTD
     GQIRTGRDIA VACLLGAEEW GFATSPLIAM GCIMMRKCHL GTCPVGIATQ DPYLRKKFAG
     TPEHVINFFY YLANELREIM AKLGFRTINE MVGHAEKLRV REDLRNTKTA NIDLTPILTP
     AHTLRPGVAT HRVRKQDHRL HVRLDNKLID ESEITLDKGL PVQIDADIVN TDRALGTTLS
     YRVSKRFGED GLPNDTIHVN IRGSAGQSFG AFLAPGITLE LEGDANDYVG KSLSGGRIII
     YPHKNSSFKP EENIIIGNVC LYGAIKGTCF FRGVAAERFA VRNSGATAVV EGVGDHGCEY
     MTGGRVVVLG ATGRNFAAGM SGGIAYVLDM AQDFHTKVNV EMVELGPVTD PKEIAFLRGL
     IEDHRHYTES ELADRILQDF NHVLPRFVRV MPTDYKKVLE AEEAKKVAAK RTLPENLRSQ
     FQKAEEEAKK LAEKKASEEE EIEAEPKVQD LEDAIVDTAA EEKKVVLLDK TKGFMKYARR
     SEKYRSVKSR TRDWQELSSR VTDEDLKYQT ARCMDCGVPF CQSDTGCPIS NIIPKWNELI
     FKDRWQDALN RLLMTNNFPE FTGRVCPAPC EGACVLGIIE DPVGIKSVEC AIIDRGFEMG
     WIVPRPPPQR TGKTVAIVGS GPSGLACADQ LNRSGHKVTV YERADRFGGL LMYGIPNMKL
     DKRVVQRRID LLAAEGIEFV ANTTIGENIT VEQLRSDHSA VVLAAGSTIP RDLPIPGRSL
     NNVMFAMQLL TANTQALLAN NLEPIAEMIR GKDVVVIGGG DTGNDCIGTS VRHGAKSVVN
     FELLPHPPSD RASDNPWPQW PRIFRVDYGH TEVQAHYGKD PREYCILSKE FVDDGEGNVK
     GIKTVRVEWK RTTSGGWQMS EVPGSEEFFP ADLVLLSMGF VGPDAQKLEV ERDGRGNIKT
     KAPAPGHVNY HVDDNLFACG DCRRGQSLIV WGIQEGRQCA RNVDLFLEHN TDLPADGGIV
     KRSYDMLEAK A
//
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