ID A0A1E4TU37_PACTA Unreviewed; 1313 AA.
AC A0A1E4TU37;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=PACTADRAFT_2939 {ECO:0000313|EMBL:ODV95234.1};
OS Pachysolen tannophilus NRRL Y-2460.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetales incertae sedis; Pachysolen.
OX NCBI_TaxID=669874 {ECO:0000313|EMBL:ODV95234.1, ECO:0000313|Proteomes:UP000094236};
RN [1] {ECO:0000313|Proteomes:UP000094236}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-2460 {ECO:0000313|Proteomes:UP000094236};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; KV454014; ODV95234.1; -; Genomic_DNA.
DR STRING; 669874.A0A1E4TU37; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000094236; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000094236};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1313
FT /note="SSD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009163382"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 607..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 850..869
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1112..1132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1139..1159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1219..1244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1256..1279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 604..774
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1313 AA; 147467 MW; 099C2FF2DAB3C72A CRC64;
MLLRVILGLL VTRFVVVLAL FEVADITPIH QEGYCALYGS CGKKSLFGSE LPCASNVEAV
EPSMKELDLL KEICGWDNVD KVCCNENQLV DLKSNLQKVN PLISSCPACK ENFYQFFCHF
TCSSNQSLFV NVTETMISPI TQKEIVTELD EFVNDDYVSG FFNSCKNIKF SASNGYAMDL
IGGGAKTYKE FLKFLGDEKP LLGGSPFQIN YKYENDGIED NTISPINFTS YACNDTDYKC
ACSDCQNSCP VLPAASVHKH CTVGIMPCFS FSIIMIYIAL ISGGLAFYLK RNSKKYLFAN
PLLVTDELGT ADDDDDDDDV NFLNDGSAVL SSYALNDYLE SCFCKLGLYC ALYPATIIAT
SLIIVTALSS LMFLIKLEKN PINLWVSSDA ESFKQKQMFD KNFGPFYRSE QVFIVDDSPN
NDNNAGSILD NYSTLKWWFE KENEIKNLAY TNNRTGTITT LDDICFRPME DSSCVIESFT
QYFQGDINLF PESQYKQKLK NCIDSPVNCL PDFQQPLKKE LLFGGYEDDD ALTSKAIVIT
FVINNSNEED SDYMENVSNW EKILEDYLLN LQNITLNDNS KNIRLSFNTE ISLEKELNKS
TNTDIKIIVI SYLVMFAYAS LALGGTITFF NVQTLITTKF SLGLIGIFVV LLSVTSSAGL
CALFGVKSTL IIAEVIPFLI LAIGVDNIYL ITHELQRFNK NASDNYESIP ERIAKTLGKI
GPSIMISSLS QFACFMLATF VSMPAVKNFA KYSAGAVVIN TALQLTAFVS LLSLDQKRTE
NNRLDCFPCV KADGRIALPS ENRNGTDTIL SRSIIPELLE NNKNTSGNFL TKFIKNYYAP
FILQKKAKKF ILGIFFIWFG TSLTLLPGIK FGLDQRIALP NDSYLIDYFN DVYRYLNVGP
PVYFVVDDLN VTSRENQQKI CGKFPSCNEF SLLNVLEEET KRPNSSFIIE PPSSWLDDFL
LWLNPELDQC CKFKKNTNET EFCSPSSPTR LCEVCYANHQ YDFVTMDGFP EGSDFIKFFQ
QWINSNSDGE CPLGGKAPYS HAIKFNSNDS NAMSSYFRTS HKPLRSQDDF IEAYRSSLKL
IDELVKLTGI EKLFSYSPFY IFFVQYETIV KLTFTLIAVA LFIILLISST LLGSIRISGL
LVSTVIFILT DIAGIMSLWN ISLNAVSLVN LIICIGLAVE FCTHIARGYT FQDRTLISPE
SQAESKINDT QSIRAFNTLI NIGGSVFSGI TMTKFIGILV LYFTRSKIFE IYYFRMWFSL
VIVSSLHSLI FLPVLLSYFG GEGYCFSENT SFVGTDLLDR LAAYENENSY DSD
//
