ID A0A1E4TUP4_PACTA Unreviewed; 473 AA.
AC A0A1E4TUP4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Pre-mRNA-splicing factor PRP46 {ECO:0000256|ARBA:ARBA00026147, ECO:0000256|RuleBase:RU369036};
DE AltName: Full=Pre-mRNA-processing protein 46 {ECO:0000256|ARBA:ARBA00033071, ECO:0000256|RuleBase:RU369036};
DE Flags: Fragment;
GN ORFNames=PACTADRAFT_50218 {ECO:0000313|EMBL:ODV95503.1};
OS Pachysolen tannophilus NRRL Y-2460.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetales incertae sedis; Pachysolen.
OX NCBI_TaxID=669874 {ECO:0000313|EMBL:ODV95503.1, ECO:0000313|Proteomes:UP000094236};
RN [1] {ECO:0000313|Proteomes:UP000094236}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-2460 {ECO:0000313|Proteomes:UP000094236};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in pre-mRNA splicing and required for cell cycle
CC progression at G2/M. {ECO:0000256|RuleBase:RU369036}.
CC -!- SUBUNIT: Associated with the spliceosome.
CC {ECO:0000256|RuleBase:RU369036}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369036}.
CC -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family.
CC {ECO:0000256|ARBA:ARBA00025726, ECO:0000256|RuleBase:RU369036}.
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DR EMBL; KV454014; ODV95503.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E4TUP4; -.
DR STRING; 669874.A0A1E4TUP4; -.
DR OrthoDB; 118158at2759; -.
DR Proteomes; UP000094236; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR045241; Prp46/PLRG1-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19923:SF0; PLEIOTROPIC REGULATOR 1; 1.
DR PANTHER; PTHR19923; WD40 REPEAT PROTEINPRL1/PRL2-RELATED; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|RuleBase:RU369036};
KW mRNA splicing {ECO:0000256|RuleBase:RU369036};
KW Nucleus {ECO:0000256|RuleBase:RU369036};
KW Reference proteome {ECO:0000313|Proteomes:UP000094236};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU369036};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728, ECO:0000256|RuleBase:RU369036};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 195..236
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 237..278
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 279..320
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 321..362
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT NON_TER 473
FT /evidence="ECO:0000313|EMBL:ODV95503.1"
SQ SEQUENCE 473 AA; 53450 MW; D944CD94CA3DDAE0 CRC64;
MSSGNIAETV ESLSKRRKIL FGDDFFSEND DLESNEVYIK TRLKNDEAYK KLPKYLIEEQ
ERENGDKGYA GSLLSKFNKE VEVANKKFDK DIIENGDELT VKIIQEIKEE ESQDIISRKI
GNKEEDLKEL VLVPNSKEEH TATTVNTRSI GNTGLPFDDS TTRSNSGSLL FQETQKASNF
VKPEWHAPWR LMRVMVGHTG WVRSLAMDPE NKWFASGSAD RTIKIWDLAS SKLKLTLTGH
IMAIRGIVVS PRHPYMFSCS EDKTVKCWDL EKNKIIRDYH GHLSSVYTID IHPSLDIIAT
GGRDSTVRVW DIRTKLAIHT LTGHDLSVTN VKCQASEPQI VSSSMDSTVR TYDLVAGKTR
QVLTHHKKSV RGLVLNEYEN TFASASSDNI KQWKFPDCNF LQNFKPKHNA IINTLSLNPS
GVMFSGADNG SMCFWDWKTG HKFQELATTK IPGSLESENG IFTSTFDKSG LRL
//
