ID A0A1E4TZ60_PACTA Unreviewed; 2679 AA.
AC A0A1E4TZ60;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=PACTADRAFT_15542 {ECO:0000313|EMBL:ODV97042.1};
OS Pachysolen tannophilus NRRL Y-2460.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetales incertae sedis; Pachysolen.
OX NCBI_TaxID=669874 {ECO:0000313|EMBL:ODV97042.1, ECO:0000313|Proteomes:UP000094236};
RN [1] {ECO:0000313|Proteomes:UP000094236}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-2460 {ECO:0000313|Proteomes:UP000094236};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KV454012; ODV97042.1; -; Genomic_DNA.
DR STRING; 669874.A0A1E4TZ60; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000094236; Unassembled WGS sequence.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000094236}.
FT DOMAIN 1316..1506
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 560..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2679 AA; 303909 MW; 154410D0221CCCA7 CRC64;
MGLIWDKSNI PAGSLVESIY SRIGPQLPLK SGLTVSELEI DVFFVRSRNT LLKIAETDKF
SDMIRCTCSI LEEINAYDKY VPLVDRKKLS LRSILVMLRL LSDLLEVNWN TMEETSVKYI
KKDYNSNELS SVAGIGSSAS RVYYHTVRPK KLDDDTMNKA LAIIANLKSG RAVLEKINEM
KGNENFEPNH IHQSLIDSID LNCESILRYL AASNPGNFLF FLKSQLIEKQ STPITNININ
ANYYQYADLL SLIYFDENLI ISYLKKLASE IEAIKLETHQ QLVLLFLTES IRFWILSNPQ
QYVKAVNSTN SELSNVSDKI FESLFKKFDL NFQYFESLSV FLIFTLLISP TSLDHFMNAN
KLKVFAPRTN QQLFLKEIIK QVTIKGPKLT AATRCIVNVM IIAGSTKKYN PDSQLVKFSF
HYSELLYDTL SMDNPCTYIA GAVTTLVDSL RVDYFVAATI LLGDQFINKV IKQVKDPEIS
LPIMKIISGG LRALSTNPDA KKYFIIYLDQ CSNELREFIL KAAELVIKDS NSQRIAASAS
IPSSSPPLVS AYSSPVSPLV TEKPSTLKDD SSAFSSTSKD SSSGSSISGG NVFPHHHRLP
PKPHKKDSIS NFRLLKNKRE SKKQTLYRSS SLSAQQLVTQ SIAHSSGSTS TLSPIEICDT
LVLYKTILVN LLAVYRAKPL AYLFPEGATE EFFNDLIKNP VFCKNCFTKV EELISPIVYL
VAEDDSNIVD AASLFSLGFL EKLRSAKSFG AKMFFVGACS YNILAVSNLL GESLETQLPV
NKVKEVLDFL VTLMEGKYNG MNSELSPISS LEDIHQASIC QEINESLERA FLATFLLPDL
DIFRLTRRAL KYFILEADAN FHEDRCYADV NMTLYKSIND DASVITGLVA LQRKMKKLYI
DKVRPTSGVI ETWLKLFSKW QSVVEQDKDD SFYANNLASA SGIFLTNSFK DKKLREEFLE
KIDTFITQKM QLLESANLRI RETAREVLSS EMHPLCFKFV VAAMVKQTAE IKKKDVTALT
ETDLSLIEQY ISIVRYYFTA DPQYVYSLVS DLYLSTLIFV QILDSIPDSF HVLKIKLKLG
KVCQFIDSCK AKMSTWGLIK YRNIFARRFL EWTEKGLMHE SGEKNKVTKV LLIAKKTSST
LIPSDTKEKR EMDLLYFDVG VESLKVMVGL LESLPLEAPQ ATHEKELIRS KKVVFGNYFS
LLYRILEKYN GINSAEMGLS LKHKINIVVD SAVLGLANLI QSNVDVGLEF ALPLSYNQSR
KIRLSLLKVF ANIVDRVNVY DNPDIENARI FHECSQLIAK NLPLAVSIAE SCPNSDIDTL
ALSLLSISDN KIQILDTVCA LLKREISNVK NEKNLLRYNT VATRMLALYC KRGGLDYLQR
VLKPTLLKIA ESKQNIDIDK LSIDDPSSQE KLDVFMESLH ELVNSIVGSI EYLPNDFKYI
SSVIYETTGS ILPDSKTYSV SAFMFLRFIV PAIVTPESSE IINFIPDAQF KKSCLQLARV
IQILANSSIT SIKSPLLLSR MNELTILHVQ ITNFLKEVAK FTPKTDFIDP VNVTENFDFR
FLHRFFYNYA QKIRECYLSY PDISIEEKIE VFSKFDNYLC ALGQPHMLYG HQIPESIKEN
SKEGENSLYE FMSKFSMREF DSSEESLVHE TISSDGTPTI VLNYCSLKSA SAEDSELLMY
YIFHVASKIW DSKFYIVIDC TGFNGTVEFF KAIDKLAQLY VTDIMRKNLD RIYYYNVSQK
YFGILLQNLK MLEVSSFLDH SKDIFHFASC FDSNKIGFGL SASSTAVGDD SRVVFNDVSL
YEPLQKRFVP VTIKIGDEFL QIGFRQPTKF KVCNVMKSLT ITDIYRISDL SGAEASSITG
VPDEICITNS IDGSQLILAS PKKIEIMRTI YFSKTRNTSL SHKEEYNITR IEFWIGELIN
IDFVGLLSDD EEIRKVAYTL LCSLSKSFRI DLGRRMQSSS SVNFPQDNAS YVIKTAKTLA
ENHKNYSYDI VNGFFAAYKN SASYQRPSTI MYVSAFIQDV FKNINLLDEE FQDEKASALL
RKFIEVSIMH KENLVIFQRY VWSKLALQDG IAFILIKEVV GAAIDREAEG KPWDDIISLL
TLTPTVEVCG KVVTRLRELS HIPKPENESS IFTHTSWIEI TVLVNACVTL FFDSLFFSEM
FMADILYIST IYMDMGPKEL RVSLHKLVVN VMNSFLSKDD LSEENKNQII SIISNFYDDR
TKLLLGLNRD GYTTNLIEND ANIIQKISAL ETYCESLIKF ISVSGDIADR NKWRARWNSY
AVDAAFRDNS MLQDRAFLLL GTLASYGVTD MLVGKVLITT VGFCQQIPDI KSFNLIICAL
YTLGRVVEGL SPSSPYTERF YWLSLTLNYA DSELFAQTSI QLLAKSLEAI DKRGKFVNGD
LIEGLFKKRE IFSSVIEDYE KSFDLAVTPE NLDLIVISIF IRGLQERHTK HSAFTALLIS
FKVRAKNAIL KSKITNGPID DRCFSYLVII FILVKSDNEL LDYMKQASIE NLELIKLDDH
ISIPKVLVDF LLSNSDFPVL TLMKGTIYQS SAAASELSNY RFLLMYKYIS ERSERLRWLL
YPEIKNLLRK VCTNTSTQLL LNCAYDISSD AIKSSKYQRL EEFAEELNEL VKNYNLVGAK
DMRFAECNLF ILNDRINGAV IPTLIKMINT ILSSVLDDD
//
