ID A0A1E4U333_PACTA Unreviewed; 4112 AA.
AC A0A1E4U333;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
DE Flags: Fragment;
GN ORFNames=PACTADRAFT_20118 {ECO:0000313|EMBL:ODV98401.1};
OS Pachysolen tannophilus NRRL Y-2460.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetales incertae sedis; Pachysolen.
OX NCBI_TaxID=669874 {ECO:0000313|EMBL:ODV98401.1, ECO:0000313|Proteomes:UP000094236};
RN [1] {ECO:0000313|Proteomes:UP000094236}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-2460 {ECO:0000313|Proteomes:UP000094236};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; KV454011; ODV98401.1; -; Genomic_DNA.
DR STRING; 669874.A0A1E4U333; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000094236; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000094236}.
FT DOMAIN 1772..1909
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2056..2255
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2399..2547
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2730..2886
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2996..3051
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3198..3239
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ODV98401.1"
FT NON_TER 4112
FT /evidence="ECO:0000313|EMBL:ODV98401.1"
SQ SEQUENCE 4112 AA; 473242 MW; C72CA3EBEB6F47D7 CRC64;
VSTIAIIKPK GSLSSEIPLE AQLQVFNLQH NEKEKNTFET LRALISNGIS PYFDSLTNKV
SDDNGNSGNV GEYSSIEITK KKLYELVTLL GNSQHNIQTP NLLMSVNPII KKSIENYGND
AIEHIESQNL LTDSSFLNEL QNSVNTWIKL CQEVTHLNHD PASGTAADEI SFWISLEKAL
LSIQEQLSSA EVSLTLDVLK KAKRFHATVS FLSDTGINEA LLRAQKYNQL LKDFPLDEIL
SLTSFSKLEE AVILVFNHLK KLRVTEYPIS RVLPFVELIS VEVEIRLRAI LKEYDLAALP
YNEFNDIMNK INLCFNTYDE QLKEFISLAR ELSRKRSEKL ILVRINSKTD TLKEKIYQIN
SFRKSHEELK TTIHLLNNEE LNDLLSYAYE SIKVIDIYDQ NKWNSAETIY NERLAKIEAI
VIKMLKDSLS NCKNANEMFG IFEKFSTLLA KPNIRNSVQE YQSQLLEIIK SEIQNLSSQL
IQQKEISKLF NLRDLPPVTS MIIWAKQVEK NLNFFSDKLQ LVLGDDWKQY PEGQKLYAEL
SVFKNKLDVQ PLYESWLKDS LHMGNNSENL KIFKIIKVNN NNNNVKSDQK FFEIVINFDY
SIIDLFKEVK HLSFLKFNVP HSISLKSRNI RKVYPKIISL SETLSLWNLA LQEVDKLSDL
KMLMDPDKER IIELISGLVD IEWGTLIKAQ DIGEVDDELD GSQSFMKDLY EMKVWNNVNH
LEEVTLVFYA NLEFLNKTKA SLIQLFEQLA IIKYDFDEFS NLISEVQKIV DEIILKGFTN
VGNLVSVINE KLSQILTNKC IKELDLWYNS VNFDNSDDLS DDFDNEKSRF VSYLKFEMIV
KDQTIMISPM IESAKVSWLL GLQKLVKVIL DQKKITSERF DVFQVNAVNA NSKIKIDETQ
KLETFSSIIF FIARDIERCL NLVDFKFKKI SKYLEDCFKF QSLWELQIED VVVFLGEDVE
SWILLLNELK ESRDAFDTVE TSKSFGYITI DYEHIQFKVT AKYDIWQRQI ALKFSEVLNL
SMKNFHSAVL NSRKSLEKLD YKDSIQDTIS LISNINRIQL NLPYFEARLK LIEQAELLLV
KNRFRFGSDW LTSEQVHDDF FSLIEIFDKR SKLIEGKRDS IISKINSESL KIEDSISTAL
FDWSTAKPVS GNIAPAEALK ILVTFENKLI SLKKSKDDLV SSSKILGIDL KLVSSVESTL
EEISDLKNVW NSINELWETL ANFKTQKWIE ISPLSLHRQL DDLLSKSRSM PLRIRQYTAF
EGAQDIIKNY IKANTLVTDL KSAMKLRHWQ NLFKSLNKKF VFTSMEEMTL GDIWDLDILA
NEGLFKNMII QAYGEKSIED KLNDIKETWK NTTFDLFNYH DKCRLVKNWD VLFQICEDNL
NSLTTMRHSP YYLLFEQEAS LLEEQLNKMF SLLDIWIEVQ KEFVYIDGVF GGNSDVRKLL
PLETSRFSNI SSEFFLILKS VYKSAIAIDS LTVSDIHRSM ERTLDVLIKI RRSLSDYLEQ
QRDNFPRFYF VGNEDLLEII GNSNDLPIIA KHFKKMFAGI ADASVKKETG EITHIISEEG
EHIELFNSVQ LKESPPLHEW LAELELETKI TLSKLLENSI NEFSNILGND FEMESLVSWM
DSYPSQICIV TSQVCWTKAI EAEILGSSNL DAVKSNIMKA LKFLAKLVNQ DQSLIKRRKF
ENLIIEFIHQ KDIITLLVAK GVNSIDNYSW RSQLTFYYDS ENPDYLSRLI VRQANSSTKY
GFEYLGVPAR LAYTPLIDKC ILAMTQALNE RKGGSPFGPA GTGKTETIKF LSQNLGKMVY
IFNFDESFQF SSISRILLGI CQVGAWGCFD EFNRLDEKML SAVSTQIEKI ELGLSFQTSS
NKIELLGKQT AVHPESGIFV TMNPGYAGRS TLPENLKKLF RSFSMNKPDR EVIAEVVLNS
QGFTTAASLA KKIVPFFSQL EEKTSRQTHY DFGVRALKST LIHCGINNRK TIDTNAGVDE
LLIVLKSLEE TIRPKLTSAD EKIFTKLEDE FFGLSYQLDS QEELISCLKT VSQVSGITLS
SEFIKKVIQL YQIQSTHHGI MLVGEAGVGK STIWKTLLSA LDRIEDCESI RYIIDCKVIT
KDKIYGSLDP ITRDWTDGIF THILRRIAEN LRGESSRRTW IIFDGDIDPE WVESLNSVLD
DNKILTLPNG ERISLPPNVR LIFEVDTLRY ATPATVSRCG IVFIGNPVVN ETELLSKLVF
DFGSRDGFDE DSSNLSFQNL QKSYSQCILN ILKPTVLSEI IAKGSTLVHY MDYNVVHTLT
MFQMMSRVFL DKIASSGYFD IVTEFTTKAV LLSLAWAFAG DSSTEDREMF SSFLLDMFNE
NIPGGTLFDY TINLPNCDFV TFFVPEISLE KQELLKPDLL IPTTDTVKHE ELIYSIIHQH
KTLIMCGPPG SGKTMTLFAA LRKSPDLVFV DINFSKETTP ELLLKTLEQY CDYKKLASGT
ILAPKIPGKW LVIFADELNL PKVDKFNSQK VISFMRELVE RGGFYKSNQW IHLKNVQFVG
ACNPPSDPGR HALSMRFLRN TMVISVNYPN KKSLCQIYNT LMTSIFRGSK LIQYATFFSS
SIIDIYLNLK SKFTEEIFSP RDITRVIKSF FVYLEDASDL EKALRILLFN LLRVFSDRMS
KEIDRIEIFE IYKTALESHF PNISPEVFKQ PLLYSNWFSM GYEEVKYAEF RSFVSERLRI
FCEEETDVPL VLYDELLDHV LRIDRVLRQP QGHMILIGTS TSGKTTLAKF VSWVNGLKTY
KLLTNRKFSL EDFDQELRDV LVRVTIKNEK LCFIVDESNI LETAFLERMN NLLSNCEIPG
LFDEEEIKVM TNRLGLEESE FTNFFKNKIS ENLHVIFTIS DSDDIHSPRI LSSPALLNRC
AVNWMGDWSN KTLYQVATSL IHNLPVDMPN YSEPASFEKC ITQSIQSYGD VVVDSLVFIH
RAKVNNCDRF FQSPGTFLDF TNHFSRIFMQ KEEELQNHQK HINVGLDKLR DAVLAVRDLK
EMLSSQKADL ETKDKEARSM LNKMLSEQNE AERKEEASIE IQTALEEQEK EVTKRRAIVM
EDLAAAEPAV LEAQRGVKNI KKEHLNELKA MRTPPEAVVL TLKSVCDLIG YNPETWRDIQ
SIIRSDSFIV DIVNFDNERQ CTQDVINYMH EKYLSRPDYN YTTANRASKA CGPLLQWVEA
QIRYASILEK VGPLRDEVHT LENEAKQTKV KLNAVDEMIR DLRNSIEHYK DDYSSLIRET
EQIKTAMSTV VQKVRRSEKL IEDLTGERER WRASVKEFHL QRKCLVGNSL LSAAFLSYCG
YYDQKTRFNL LRIWKSKLMS SGIAVDENYV TTNYLSTPSN IIKWEENGTP NDDLFIENMI
MLTHSQRFPY IIDPSGKMLE ILTAEILPRK LIITSFLDDG FVKKLENALR FGSSILIQDA
EKYDPIISQI LSKEVHRTGG RTLMCLGKQE IDCTDGFKLY LYTRDPSVKI PPFVSSRTTT
INFTVTASSL EAHSLNMTLK KENPEIEEQR LELIKIQGEY KVHLRKLEDQ LLKSLTDSNG
NILDNDEIIN TLEILKHDST DISKKMEETS HIMEKMDSIL VQYYPLASSC SSLYIMLDSF
KNANRFYQFS LGYFVELLTC VLNSERNLDP RHNKVDDLVK KLYQEVYSRT ALSLLHEDRV
ILCLTMFALY FNFKHNVSLL PIVIAILRTI SKKDANVEDL IRITNLMEIK VDHELLESCY
NDWSEESFKT LIKNVKDYDF IIPLLKSSFK IKNASNECLS VFTEVSKFFL ENSNSPYGSK
YSLSDVVLFN NEHSSKPIVL CSPEGYDATF KVESIKQEFC IDKLVVIAMG SNEAIEIADK
EINKAAKEGY WVLIQNVQMS NNWLEYLQKN LESLVLPHRN FRLFLTCSLA SKLPITLLRE
SSVLIFENSP GIKSVMLELF VNIPHEKLET EKPIEKKYLY FLLCWFHAVL QERLRFVPIG
FNKYYEFNNT DFELGIATID KWVAEIAKGR TNVAPEHLPW EALQILISEI VYGAKVDIKE
DLQILIELSR KIFRLESFDN GFNIIEYDEI TSLDKLFPPE IKSVKNLSDW IRNELPDMQP
PTWLGLNNDV ELKIKAEKGR QVASTVSTLL EQ
//
