ID A0A1E4U3M4_PACTA Unreviewed; 1403 AA.
AC A0A1E4U3M4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=CNH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PACTADRAFT_48324 {ECO:0000313|EMBL:ODV98603.1};
OS Pachysolen tannophilus NRRL Y-2460.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetales incertae sedis; Pachysolen.
OX NCBI_TaxID=669874 {ECO:0000313|EMBL:ODV98603.1, ECO:0000313|Proteomes:UP000094236};
RN [1] {ECO:0000313|Proteomes:UP000094236}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-2460 {ECO:0000313|Proteomes:UP000094236};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KV454011; ODV98603.1; -; Genomic_DNA.
DR STRING; 669874.A0A1E4U3M4; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000094236; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000094236}.
FT DOMAIN 666..853
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1060..1353
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1382..1403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1403 AA; 159725 MW; 59224F701CA52B4F CRC64;
MSSSRFNGNI QRDDVFSDIF GSKRPVRGSA GSSPTHQQPP LDLSNIPLIP SPSSSQSSQQ
KIINNIPPHL QPQLNSYQQQ EQPVTLDPTK SDSSSGSSEE LRYLYGNQKQ QQAAQAQAQR
QLNLPVRPQY GPQYLQGQAN LPARPQQNHY AQQAQQAQQQ QRPHNLPIKP QTNSHMLQQQ
QQQPQQQQYI PQNISNNQQR PVNSHPSSRG GNLPYPNVQQ QQQQQHQYNH PQPQPPPVST
TNTLGAIPER YNYSENTSPL HHPTNNRSPV LRQSFNFFNR STASLSQRSV STSAVNSELR
NSNNFQNNGN NNRAMSLSST SHDRYHQHHK PTTTASGRTI PQKVDVSDTN INNGNNTYSH
SSNGNSSPGL NSKSRSFSSL TTKVSKRTLS QSSQSNLKNT DRSYSSSSLT SKTVFTSSSR
RPSVYPALLS RVARLFKERI VLGSKLKNGL EYRDAFSGSE AVDIISHIIR TSDRNLALLL
GRALDAQKFF HDVTYEHRLR DSNNEVYQFN DFTFFNQNNT GNGTQTNLNG NKRNSFNSEN
TLNNASMLES PSVSSTIHQL PSSASINQQV NNGSSALLNQ QDILVNGVFT LLTECYSPTC
TRDRLCYSIA CPRRLEQQAR LNLKPQGGLR RNDTHISLHE NDEKKHLWSY SVPKSVLESV
DKRELKRQES IFETIYTERD FVKDLEYIRD FWIRPLRESN IIPEREREKF IKTVFSGVNE
ILAVNGKLAA ALTRRQNKKS IVDQIGDIFL QYIPHFEPFV YYGAGQIFGK YEFERQKTTN
PLFARFVEET ERLKESRRLD LSSFLSKPTS RPARYPLLLK AIRDHTREDS PDYENLNKAL
ALLQKLLDRI NIETGKSSDR YQLILLKQKL QFRPGEFVDL KLTTPNRRIL YHCVLKKRNY
QDKENQGEVQ AYLFDHALLF VKIKIVNKRE QHRVYQRPIP LQLLLLSVTE EVPNLKTMMK
RSSAMQISAL SSASSLVASS PPSILMSSST SLNNGNSNSN KFPVTFSYLG RKGDYLTLYA
PKLSIQKTLI EKIEAQHKKL IEANDVFTFT PLCQKFFDYS NKINCVVPFD GGRKLLYGTD
SGIYLSEIKK SDQGKRIVSK PIKIISKINV MQLEVLEGYQ TFLVLTDKKL LTWPLEILSQ
TTIDPFKNAK IGKELISHVS FFRVGICNGR MLVCAAKNGS NHIIKVFEPI DPIQQKKLNK
RKFKNETKEI VFSSEPVSIS FINSRLCVGC TKGFEIVSIE ENKMELLLDP ADTSLDFVIG
KEGLKPLEID RINSYFLLSY SDFSFYVNGN GWRSRPQFLI NWEGLPQDFA IWYPYLLGFD
SSFIEIRHVE TGDLLRIIYG ENIRFLHRSS QEILYAYEDE KGYDVVVSLD FWDKSIKKNN
TTTTTTSTTT TATNNNSDEP SAK
//
