ID A0A1E5AGN3_9RHOB Unreviewed; 703 AA.
AC A0A1E5AGN3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OED48987.1};
GN ORFNames=AB838_08470 {ECO:0000313|EMBL:OED48987.1};
OS Rhodobacteraceae bacterium (ex Bugula neritina AB1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae.
OX NCBI_TaxID=1868286 {ECO:0000313|EMBL:OED48987.1, ECO:0000313|Proteomes:UP000094333};
RN [1] {ECO:0000313|EMBL:OED48987.1, ECO:0000313|Proteomes:UP000094333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AB1-7 {ECO:0000313|EMBL:OED48987.1};
RX PubMed=27681823; DOI=10.1038/srep34362;
RA Miller I.J., Weyna T.R., Vanee N., Fong S., Lim-Fong G.E.;
RT "Single sample resolution of rare microbial dark matter in a marine
RT invertebrate metagenome.";
RL Sci. Rep. 6:34362-34362(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OED48987.1}.
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DR EMBL; MDLF01000058; OED48987.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E5AGN3; -.
DR STRING; 1868286.AB838_08470; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000094333; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 298..475
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 480..573
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 703 AA; 74745 MW; 61DA665B6035D6BC CRC64;
MSQKNPQAQL ELTESIAVIQ FQNAPMNAMS PGLPGAILQQ LRAAQDAGAK AVLLVPGGSG
VMAGADISMQ GKDWPADEPL MSDLIRTLDD CAVPTAILLR KSALGGGLEI AMACRWRFAT
AGTKLGQPEV NLGIPPGAGG TQRLPRIVGI QHALDICITG RPIDATKAQS LGLIDALVPA
ETAQEACLSF LRDALKAGQI PAPAGARQIP EVDESVFETA LAQATKRRRG ETAPTAIINA
IRAAAQLPLS EGLAQERKLY LDCVASDQAA AMRHVFFAER AALKGHTSKE AQARPITKIA
VVGAGTMGSG IAIAFMMAGL HVHLAERSGE ALQAGLDRIR AFFDGRVKAG RMKDTAARDM
LARLSSKAAL DDLPPVDLVV EAVFEEMAVK KSVFATLAQA TAPGTILATN TSYLDVDEIA
AAVPDRVSDV LGMHFFSPAN IMPLLEIVRG RDTADDTLAT VLALSKTIGK TGVVSGVCHG
FIANRSFSKY LREAEFLLQE GATPAQVDAA IRAFGLPMGP FAVRDLAGLD IGWAMRKSTA
HLRNANERYS TVGDAICERG WFGQKTGRGF FNYAEDKRRG AEDPEVLNII RETGAAAGIT
PRQISDQEIV DRCLLAVVNE GAKILQEGIA RRASDFDLAW INGYGFPKWR GGPLFWAEQT
GLQKVLARIG SFHGDHDFWE PAALLQELAA DGKTFAQHTG APT
//
