ID A0A1E5GSH8_9ENTE Unreviewed; 855 AA.
AC A0A1E5GSH8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=BCR23_10050 {ECO:0000313|EMBL:OEG15170.1};
OS Enterococcus quebecensis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=903983 {ECO:0000313|EMBL:OEG15170.1, ECO:0000313|Proteomes:UP000094764};
RN [1] {ECO:0000313|EMBL:OEG15170.1, ECO:0000313|Proteomes:UP000094764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 26306 {ECO:0000313|EMBL:OEG15170.1,
RC ECO:0000313|Proteomes:UP000094764};
RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEG15170.1}.
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DR EMBL; MIKB01000016; OEG15170.1; -; Genomic_DNA.
DR RefSeq; WP_069635659.1; NZ_MIKB01000016.1.
DR AlphaFoldDB; A0A1E5GSH8; -.
DR STRING; 903983.BCR23_10050; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000094764; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 683..699
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 609..616
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 855 AA; 96599 MW; EBC32F5A5DE7609D CRC64;
MPQKTKNTPM MEQYLAIKDQ YQDAFLFYRL GDFYEMFYED AVNASQLLEL TLTSRNRNAD
DPIPMCGIPH HAAQGYIDTL IEKGYKVAIC EQVEDPKTTK GMVKREVVQL ITPGTVMTSK
GLDAKDNNYL TAIVEENGIF GLAYVDLSTG ELKTAVLGDE DGVINEASAL QTKEIVLGSP
LSETLQQTLK DRLNIIFSEQ NQAEENAEFS FLTSELTHPL EVEVTGKLLT YLTTTQKRSL
AHIQKAVEYQ PDHFLKMDHY SKFNLELTQS IRTGLKKGTL LWLLDETKTA MGGRLLKQWL
DRPLIQEKQI QTRQEMVQSL LNAYFERVDL QSTLTKVYDL ERLAGRVAFG NVNGRDLIQL
KTSLEQVPLV RELIVGINQG EWNDLLLDLN PAEDIVELIN QAINEEAPLA ITEGNIIKDN
YNEKLDEYRD AMRHGKQWLA ELEAKERQET GIKTLKVGFN RVFGYYIEVT KSNLANLAEG
KYERKQTLAN AERFITPELK EMETLILEAE EKSVDLEYQL FLEVREQVKT NIERLQKLAK
TISAVDVLQA FATVSERYQY VRPTLKSNSK ELHIVEGRHP VVEKVLGHQE YIPNSVHMSK
DNIILLITGP NMSGKSTYMR QLALTVVMAQ IGCFVPAESA ELPIFDQIFT RIGASDDLIA
GQSTFMVEMM EANQALRHAT PNSLILFDEL GRGTATYDGM ALAQAIIEYI HREVKAKTLF
STHYHELTVL DETLTGLKNV HVGAVEKNGE VVFLHKMMDG PADKSYGIHV AKIAGLPSVL
LDRAATILSA LESEEQPLKA IEYTSEIKED TEQLSLFKEV STDELGVIDT LKKINLLEMT
PMDALNKLHE LQKRI
//
