ID A0A1E5IXV8_SHECO Unreviewed; 788 AA.
AC A0A1E5IXV8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=BEL05_07840 {ECO:0000313|EMBL:OEG74693.1};
OS Shewanella colwelliana (Alteromonas colwelliana).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=23 {ECO:0000313|EMBL:OEG74693.1, ECO:0000313|Proteomes:UP000095230};
RN [1] {ECO:0000313|EMBL:OEG74693.1, ECO:0000313|Proteomes:UP000095230}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CSB03KR {ECO:0000313|EMBL:OEG74693.1,
RC ECO:0000313|Proteomes:UP000095230};
RA Hong H.-H., Choi H., Cheon S., Oh J.-S., Lee H.-G., Park C.;
RT "Whole-genome of two Shewanella species isolated from a digestive organ of
RT sea cucumber Apostichopus japonicus Selenka 1867.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEG74693.1}.
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DR EMBL; MCBT01000016; OEG74693.1; -; Genomic_DNA.
DR RefSeq; WP_069670651.1; NZ_MCBT01000016.1.
DR AlphaFoldDB; A0A1E5IXV8; -.
DR STRING; 23.BEL05_07840; -.
DR OrthoDB; 5807460at2; -.
DR Proteomes; UP000095230; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd05784; DNA_polB_II_exo; 1.
DR CDD; cd05537; POLBc_Pol_II; 1.
DR Gene3D; 2.40.50.590; -; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 183..303
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 385..741
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 788 AA; 88585 MW; 30A5BA49DEBF9FA5 CRC64;
MSEIGKNSIQ ETVKGRILTR HHSGNALLYY VKTIDGPVKV VVNDSARVCF CLAHEAPRLS
AIASVRIEEL GLSSFSHQSV SAIYSQTGQA FRQLVRQAND LGVELFEADI RPEQRYLIER
FIALDAEFIG QAASARALPT FTASRARKRD LKITMSIVSL DFECAMDGQL YSVALYGESD
TGEMIAKVIM VGDSPQSQSV DYIDWVEDEA SLIHGLVAWF KQADPDIIIG WAVVTFDIAL
LYRRAKYHNI ALTLGRGDEL LNWKVEDKYR PETLILPGRV VLDGIDWLKA AFYQFDSFSL
EHVSRQLLGE GKAIDKVENR GESITELFQH DKLALAHYNL TDSRLVWDIF KKTHLTEFAM
ERSRLTGLEL GRVGGSVAAF NNLYLPYLHR AGFVAPSRPA SDGIESPGGY VMDSVPGLYQ
HILVLDFKSL YPSIIRTFNI DPKALIEGER LAESQTVPGF LGATFNRQGA ILPNLIAELS
AKRELAKLEN NAPLSQAIKI IMNSLYGVLG SRGCVFHDAR LASSITLRGH QIMKQTRQWI
EELGLRVIYG DTDSTFVHLA DLSGIESIDK FAENLVATIN GKWQARLAEL YNIPCYLELE
YERHFEQFFM PTLRGSTEGS KKRYVGAYTN PKGELSVVFK GMEQVRSDWS PLARQVQEQL
YYRLFAKQDV QEYLQDIIVR LQAGELDELL IFSKRLRRDI ADYTQKASPH VKAASLYCER
SGVPAYGKRG SKIEYLITLS GAEPIQFCIG KIDYQYYLDK QIAPISDPVL SVFNVSFSDL
ISKQMTLI
//
