ID A0A1E5KWT8_9ENTE Unreviewed; 489 AA.
AC A0A1E5KWT8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=BCR26_14430 {ECO:0000313|EMBL:OEH82129.1};
OS Enterococcus rivorum.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=762845 {ECO:0000313|EMBL:OEH82129.1, ECO:0000313|Proteomes:UP000095256};
RN [1] {ECO:0000313|EMBL:OEH82129.1, ECO:0000313|Proteomes:UP000095256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 25899 {ECO:0000313|EMBL:OEH82129.1,
RC ECO:0000313|Proteomes:UP000095256};
RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEH82129.1}.
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DR EMBL; MIEK01000028; OEH82129.1; -; Genomic_DNA.
DR RefSeq; WP_069698911.1; NZ_MIEK01000028.1.
DR AlphaFoldDB; A0A1E5KWT8; -.
DR STRING; 762845.BCR26_14430; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000095256; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:OEH82129.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000095256};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OEH82129.1}.
FT DOMAIN 6..132
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 139..454
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 489 AA; 55954 MW; D427DA4C537086B6 CRC64;
MITGEIKSKI DNIWTILWTE GSTNPLTNIE QLTYLLFMKD LDKAELMKEK DAIALGLPYE
SLFPEDKQNY RWNQLKQLGS ADEMFTLVQQ EVFPFIINLK GNDEETAFSR YMKDANFLIN
KPSTLQRVID IIDELPTDDK DMQGDIYEYL LSKLQQAGTN GQFRTPRHII KMIVALMQPT
PEDSIIDPAM GSAGFLVSAS EYMRANHNEL FLDEKLAEHY HTEMFHGNDM DSTMLRIGAM
NMMLHGVDNP KIAYRDSLSQ DNLETDKYSL VLANPPFKGS LDYDSVANDL LTTVRTKKTE
LLFLALFLRI LKPGGRAAVI VPDGVLFGSS KAHKELRKKL LEENQLNAVV SMPSGVFKPY
AGVSTAILIF TKTSSASKTE KVWFYDMQAD GYSLDDKRTV VEDNDLPDII QRFTHLEEET
ERKRTDKSFF VPLAEIQEND YDLSINKYKE IEYEEVEYEK PEVILEKISI LEDEILKNIA
DLNLKIGEK
//
