ID A0A1E5P2Z4_9ACTN Unreviewed; 811 AA.
AC A0A1E5P2Z4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=AS594_04965 {ECO:0000313|EMBL:OEJ23920.1};
OS Streptomyces agglomeratus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=285458 {ECO:0000313|EMBL:OEJ23920.1, ECO:0000313|Proteomes:UP000095759};
RN [1] {ECO:0000313|EMBL:OEJ23920.1, ECO:0000313|Proteomes:UP000095759}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6-3-2 {ECO:0000313|EMBL:OEJ23920.1,
RC ECO:0000313|Proteomes:UP000095759};
RA Chen X.;
RT "Complete genome sequence of Streptomyces agglomeratus strain 6-3-2, a
RT novel anti-MRSA actinomycete isolated from Wuli of Tebit, China.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEJ23920.1}.
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DR EMBL; MEHJ01000001; OEJ23920.1; -; Genomic_DNA.
DR RefSeq; WP_069925843.1; NZ_MEHM01000001.1.
DR AlphaFoldDB; A0A1E5P2Z4; -.
DR STRING; 285458.BGM19_31840; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000095759; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd03270; ABC_UvrA_I; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000095759};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 478..799
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 811 AA; 86618 MW; 7ADEEFB88E878219 CRC64;
MPSAHDPYAP HDPYAAHDPY VRVRGADEHN LRHVDVDIPR DALVVFTGVS GSGKSSLAFG
TIYAEAQRRY FESVAPYARR LIHQVGAPKV GEISGLPPAV SLEQRRSAPG SRSSVGTVTT
LSNSLRMLFS RAGTYPPGAA RLDSDAFSPN TAAGACPECH GLGRIHRTSE ELLVPDPSLS
VREGAIEAWP GAWQGKNLRD VLDALRYDVD RPWRELEQRD RDWILFTDEQ PVVTVHPVRD
AGRIQRPYQG TYMSARRYVM HTFADSKSQT LRARAERFLT AAPCPVCGGS RLRPEALAVT
FGGRTIAELA GLPLSALARA LDPAADGSET ARVLTGDLRA RIAVVTELGL GYLSLDRTTP
TLSSGELQRL RLATQLRSGL FGVVYVLDEP SAGLHPADTE ALLVVLGRLK AAGNSVFVVE
HHLDVVRSAD WLVDVGPLAG EHGGRVLHSG PPAALAEVAE SATRRFLFDR EPAPPREVRE
PSGLLRLNGV ERHNVRGVDA AFPLGVFTAV TGVSGSGKST LVGQVLAGVL ADGATGGTTG
CASAEGLEAV DRLVQVDQRP IGRTPRSNLA TYTGLFDVVR KLFTATEDAR ARGYKAGRFS
FNVAGGRCET CQGEGFVSVE LLFLPSTYAP CPDCRGARYN PGTLEVTYRG RSIAEVLDLT
VEAAAGFFAG TPAAERSLRA LLDVGLGYLR LGQPATELSG GEAQRVKLAS ELQRTRRGHT
VYVLDEPTTG LHPADVEVLM RQLHGLVDQG HTVVVVEHDM AVVAAADWVI DLGPGGGDEG
GRIVAAGPPA EVARAANSRT APYLARELRP S
//
