ID A0A1E5PL50_9ACTN Unreviewed; 1522 AA.
AC A0A1E5PL50;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BGK67_01800 {ECO:0000313|EMBL:OEJ30260.1};
OS Streptomyces subrutilus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=36818 {ECO:0000313|EMBL:OEJ30260.1, ECO:0000313|Proteomes:UP000095705};
RN [1] {ECO:0000313|EMBL:OEJ30260.1, ECO:0000313|Proteomes:UP000095705}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10-1-1 {ECO:0000313|EMBL:OEJ30260.1,
RC ECO:0000313|Proteomes:UP000095705};
RA Chen X.;
RT "The complete genome of Streptomyces subrutilus 10-1-1.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEJ30260.1}.
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DR EMBL; MEHK01000001; OEJ30260.1; -; Genomic_DNA.
DR RefSeq; WP_069918404.1; NZ_MEHK01000001.1.
DR STRING; 36818.BGK67_01800; -.
DR OrthoDB; 9810730at2; -.
DR Proteomes; UP000095705; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 8.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.1530; -; 5.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF00672; HAMP; 8.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00304; HAMP; 8.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 3.
DR PROSITE; PS50885; HAMP; 8.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OEJ30260.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000095705};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 16..68
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 108..160
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 200..252
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 292..344
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 384..436
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 476..528
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 568..620
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 660..712
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 963..1194
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1394..1511
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 1199..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 894..953
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 1444
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1522 AA; 161776 MW; 059F0586151CA76F CRC64;
MVKPTDVVTS AQASGAVGEQ QLRQLLAGLT SVRDGDFGTR LPDEAEGLLG EIATVFNGMV
DQLSLFTSEV TRVAREVGTE GTLGGQAVVP GVSGTWADLT DSVNAMAGNL TTQVRDIAQV
ATAVARGDLS QKIDVAARGE ILELKDTVNT MVDQLSSFAD EVTRVAREVG SEGRLGGQAE
VPGVAGVWRD LTDSVNFMAG NLTDQVRNIA QVTTAVAKGD LSQKIAVDAR GEILELKNTI
NTMVDQLSAF ADEVTRMARE VGTDGRLGGQ ADVKGVSGTW RDLTDSVNFM AGNLTAQVRS
IAEVATAVAQ GDLSQKIRVD ARGEILELKT TINTMVDQLS AFADEVTRVA REVGTDGRLG
GQADVKGVSG TWRDLTDSVN FMADNLTAQV RSIAEVTTAV AQGDLTQKIR VDARGEILEL
KETINTMVDQ LSAFADEVTR VAREVGTEGN LGGQATVRGV SGTWKDLTDN VNVMASNLTG
QVRSIAQVAT AVARGDLSQK IVVEAKGEVA ALAGVINTMV DTLSAFADEV TRVAREVGTE
GRLGGQAQVP NVAGTWKDLT DNVNSMANNL TGQVRNIALV TTAVANGDLS KKIDVDARGE
ILELKTTINT MVDQLSAFAA EVTRVAREVG SEGRLGGQAE VEGVSGTWKR LTENVNELAG
NLTRQVRAIA EVASAVAEGD LTRSITVDAS GEVAELKDNI NSMVGSLRET TRANQEQDWL
KSNLAQISGL MQGHRDLEVV AELVMDELVP LVEASYGAFY LAEEADGETW LALIGSFGRP
IDSPAAQRVR NGETLVGQAV RSRRILSTDN VPAGYLISSG LGAAAPANLI VLPIIVEDQV
LGVIELASFQ PFTPVHRDFL SRLMETVGVN VSTIVANART DELLGESQRL TGELQARSEQ
LQVQQDELQR SNAELEEKAA LLATQNRDIE TKNLEIEQAR QELEDRAQQL SLASKYKSEF
LANMSHELRT PLNSLLILAQ LLAQNPGRNL TPKQVEYAGI IHSAGSDLLQ LINDILDLSK
VEAGKMDVNL ERVSLKKLLD YVEASFRPLT TQKGLDFDIT TSPGVPVDLL TDDARLQQIL
RNLLSNAVKF TERGRVQVRI EPANAAELPE ELARSGSVVA FKVDDTGIGI AEEQLEVIFA
AFQQADGTTS RKFGGTGLGL SITREIARLL GGIVTATSTP GVGSTFTLYL PVTGAGSSDH
GAGAPALEGS TDGDEKSDGG SADPAADSHP RRLLVIEERA NGLLSLVAES AASDVTAGRA
ASDLAEQVEV VTALTSGDAA TMLAQSPFHC VVLELDAKGE ALRFLRALSG DTALASLPVL
AHANRRMAAD VHEEVARLAN GHHLEVLSSL DELRERIALH LSVERLRDVL PLVRPEGDQV
ADHPHVDASL ADKSVLVVDD DPRNLYAISG ILELHGIRVL HAENGRKGIE TLTSTPGIDL
ILMDVMMPEL DGYAATEEIR GMPEYAGLPI ISVTAKAMPG DREKSIASGS SDYITKPVDA
NDLVALLRQW LLPKDAAGAS RV
//
