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Entry: A0A1E5PPP3_9ACTN
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ID   A0A1E5PPP3_9ACTN        Unreviewed;       907 AA.
AC   A0A1E5PPP3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=DNA polymerase I {ECO:0000256|ARBA:ARBA00020311, ECO:0000256|RuleBase:RU004460};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|RuleBase:RU004460};
GN   Name=polA {ECO:0000256|RuleBase:RU004460};
GN   ORFNames=BGK67_09345 {ECO:0000313|EMBL:OEJ31517.1};
OS   Streptomyces subrutilus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=36818 {ECO:0000313|EMBL:OEJ31517.1, ECO:0000313|Proteomes:UP000095705};
RN   [1] {ECO:0000313|EMBL:OEJ31517.1, ECO:0000313|Proteomes:UP000095705}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10-1-1 {ECO:0000313|EMBL:OEJ31517.1,
RC   ECO:0000313|Proteomes:UP000095705};
RA   Chen X.;
RT   "The complete genome of Streptomyces subrutilus 10-1-1.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In addition to polymerase activity, this DNA polymerase
CC       exhibits 5'-3' exonuclease activity. {ECO:0000256|RuleBase:RU004460}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU004460};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705, ECO:0000256|RuleBase:RU004460}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OEJ31517.1}.
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DR   EMBL; MEHK01000001; OEJ31517.1; -; Genomic_DNA.
DR   RefSeq; WP_069919811.1; NZ_MEHK01000001.1.
DR   AlphaFoldDB; A0A1E5PPP3; -.
DR   STRING; 36818.BGK67_09345; -.
DR   OrthoDB; 9806424at2; -.
DR   Proteomes; UP000095705; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR   CDD; cd06140; DNA_polA_I_Bacillus_like_exo; 1.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   CDD; cd09859; PIN_53EXO; 1.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR018320; DNA_polymerase_1.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   NCBIfam; TIGR00593; pola; 1.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF27; DNA POLYMERASE NU; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU004460};
KW   DNA repair {ECO:0000256|RuleBase:RU004460};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU004460};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004460};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU004460}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU004460};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095705};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004460}.
FT   DOMAIN          16..278
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00475"
FT   DOMAIN          326..496
FT                   /note="3'-5' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00474"
FT   DOMAIN          663..870
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
SQ   SEQUENCE   907 AA;  98508 MW;  7ECB77FF782B2B06 CRC64;
     MAETASKKTD QTTAADRPRL MLMDGHSLAY RAFFALPAEN FTTATGQPTN AIYGFASMLA
     NTLRDEAPTH FAVAFDVSRK TWRSTEFPEY KANRSKTPDE FKGQVELIGE LLDAMHVPRF
     AVDGFEADDV IATLATQAEA LGFEVLIVTG DRDAFQLVSE HTTVLYPTKG VSELTRFTPE
     KVEEKYGLTP QQYPDFAALR GDPSDNLPGI PGVGEKTAAK WITQFGSFAE LVERAEEVKG
     KAGQNFRDHL EAVKLNRVLT EMVKDVELSK APSDLARVPY DRSAVTGVLD VLEIRNASLR
     ERLLAVDPGA AEEQAPAPVA AGVELDGSVL GAGELAPWLE ARAGAPLGIS TVDSWALGQG
     SVSEIALAAA DGAAAWFEPS ELDEADERAF AAWAADAARP KVVHNAKGLM RVFPEHGWSL
     AGVTMDTALA AYLVKPGRRS FALDVLSNEY LHRELAPAAA DGQLAFGADE TAEAEALMAQ
     ARAVLDLGEA FTGKLAEVGA VELLHDMELP TSELLARMER AGIAADRDHL EAMEQQFAGA
     VQQAVKEAHA AVGHEFNLGS PKQLQEVFFG ELDLPKTKKT KTGYTTDADA LAWLAAQTDH
     ELPVIMLRHR EQAKLRVTVE GLVKTIGADG RVHTSFSQTV AATGRLSSTD PNLQNVPVRT
     DEGRAIRRGF VVGEGFESLM TADYSQIELR VMAHLSEDEG LIEAFATGED LHTTVASQVF
     GVERSQVDAE MRRKIKAMSY GLAYGLSAFG LAQQLNIEPA EARGLMETFF QRFGGVRDYL
     QRVVEEARVT GYTATVFGRR RYLPDLGSDN RQRRESAERM ALNAPIQGTA ADIVKVAMLR
     VDRAITRAGL KSRMLLQVHD EIVLEIAPGE RERVEELVRR EMGAAVELRA PLDVSVGVGS
     DWESAAH
//
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