ID A0A1E5PZ39_9ACTN Unreviewed; 451 AA.
AC A0A1E5PZ39;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=BGK67_28405 {ECO:0000313|EMBL:OEJ34736.1};
OS Streptomyces subrutilus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=36818 {ECO:0000313|EMBL:OEJ34736.1, ECO:0000313|Proteomes:UP000095705};
RN [1] {ECO:0000313|EMBL:OEJ34736.1, ECO:0000313|Proteomes:UP000095705}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10-1-1 {ECO:0000313|EMBL:OEJ34736.1,
RC ECO:0000313|Proteomes:UP000095705};
RA Chen X.;
RT "The complete genome of Streptomyces subrutilus 10-1-1.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEJ34736.1}.
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DR EMBL; MEHK01000001; OEJ34736.1; -; Genomic_DNA.
DR RefSeq; WP_069922927.1; NZ_MEHK01000001.1.
DR AlphaFoldDB; A0A1E5PZ39; -.
DR STRING; 36818.BGK67_28405; -.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000095705; Unassembled WGS sequence.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000313|EMBL:OEJ34736.1};
KW Oxidoreductase {ECO:0000313|EMBL:OEJ34736.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000095705}.
SQ SEQUENCE 451 AA; 49949 MW; 1023DBBB355CAF2B CRC64;
MAQVRPGDAP LIHDLIGIGF GPSNVAMAIA VSEHNARVGR QEAITAHFFE QQPRFGWHRG
MLIDDATMQV CFLKDLVTLR NPASEFSFLC YLKSRGRLVD FINHKTLFPL RVEFHDYFEW
AADQVDGMVS YGHEVVGVTP VVRDGVVEYL DVTVRAGEGL ALHRARNLVI GTGLRPLMPD
GMERSDRIWH TSDLLTKVDA LDGADPTRFI VVGAGQSAAE NVAYLHRRFP AAEVCAVFSR
YGYSPADDSS FANRIFDPDA VGEFFAAPPG VKRSLMDYHG NTNYSVVDVD LIDDLYRQMY
REKVLGTERL RFLNVSRLTA VSEGPDTVRA TVQSLVTEEE TPLEADVVVF ATGYRPVDPL
ALLGDVAERC LRDDEDRVRV ERDYRIATDP ELRCGIYVQG GTEHTHGITS SLLSNTATRV
GEILDSLLDR GRKADADEVR TVADGTGSTA R
//
