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Database: UniProt
Entry: A0A1E5Q4Q8_9PROT
LinkDB: A0A1E5Q4Q8_9PROT
Original site: A0A1E5Q4Q8_9PROT 
ID   A0A1E5Q4Q8_9PROT        Unreviewed;       403 AA.
AC   A0A1E5Q4Q8;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Heme chaperone HemW {ECO:0000256|ARBA:ARBA00017228, ECO:0000256|RuleBase:RU364116};
GN   ORFNames=BEN30_16375 {ECO:0000313|EMBL:OEJ64429.1};
OS   Magnetovibrio blakemorei.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   Thalassospiraceae; Magnetovibrio.
OX   NCBI_TaxID=28181 {ECO:0000313|EMBL:OEJ64429.1, ECO:0000313|Proteomes:UP000095347};
RN   [1] {ECO:0000313|Proteomes:UP000095347}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV-1 {ECO:0000313|Proteomes:UP000095347};
RA   Florea S., Webb J.S., Jaromczyk J., Schardl C.L.;
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably acts as a heme chaperone, transferring heme to an
CC       unknown acceptor. Binds one molecule of heme per monomer, possibly
CC       covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000256|RuleBase:RU364116}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU364116}.
CC   -!- SIMILARITY: Belongs to the anaerobic coproporphyrinogen-III oxidase
CC       family. HemW subfamily. {ECO:0000256|ARBA:ARBA00006100}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OEJ64429.1}.
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DR   EMBL; MCGG01000071; OEJ64429.1; -; Genomic_DNA.
DR   RefSeq; WP_069959282.1; NZ_MCGG01000071.1.
DR   AlphaFoldDB; A0A1E5Q4Q8; -.
DR   STRING; 28181.BEN30_16375; -.
DR   OrthoDB; 9808022at2; -.
DR   Proteomes; UP000095347; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004109; F:coproporphyrinogen oxidase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:InterPro.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR034505; Coproporphyrinogen-III_oxidase.
DR   InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR   InterPro; IPR010723; HemN_C.
DR   InterPro; IPR004559; HemW-like.
DR   InterPro; IPR007197; rSAM.
DR   NCBIfam; TIGR00539; hemN_rel; 1.
DR   PANTHER; PTHR13932; COPROPORPHYRINIGEN III OXIDASE; 1.
DR   PANTHER; PTHR13932:SF5; HEME CHAPERONE-RELATED; 1.
DR   Pfam; PF06969; HemN_C; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDG01065; anaerobic_coproporphyrinogen-I; 2.
DR   SFLD; SFLDF00562; HemN-like__clustered_with_heat; 1.
DR   SFLD; SFLDF00288; HemN-like__clustered_with_nucl; 1.
DR   SMART; SM00729; Elp3; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU364116};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU364116};
KW   Cytoplasm {ECO:0000256|RuleBase:RU364116};
KW   Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU364116};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU364116};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU364116};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU364116};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095347};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|RuleBase:RU364116}.
FT   DOMAIN          12..245
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
SQ   SEQUENCE   403 AA;  44436 MW;  9D5392D8DB53003B CRC64;
     MSADKSAEKS LLVPHESLAL YVHWPWCLSK CPYCDFNSRA LAPADSDQKA YREAILRELN
     HYAEQTKGRP LGSLFFGGGT PSLMSPDTVQ AIIEAAHDHW DFQNGCEITI EANPTSIEAA
     KFRAFREAGV NRVSVGVQAL NDTDLQALGR EHSVDEALRA LDIASAIFER FTFDLIYARP
     GQGQGDWADE LERALALAGD HLSLYQLTIE PGTAFFRQNV EEVDQDLGAD LYEITQELCE
     EAGLPAYEVS NHARVGQESR HNMTYWQGGD YIGIGPGAHG RLSTSGTTRA THQMADPAKW
     SAAVARDGHA TAKVRELRPR ERLEELVLSG MRLTDGIDAR RFARQCGQEL IQVLNTDALF
     DLQTAQLIDF DGQRLAATAA GRLMLNTLIT QLLDEPQAPS KPD
//
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