ID A0A1E5QFF6_9CYAN Unreviewed; 546 AA.
AC A0A1E5QFF6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=BH720_20475 {ECO:0000313|EMBL:OEJ73314.1};
OS Desertifilum tharense IPPAS B-1220.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Desertifilales; Desertifilaceae;
OC Desertifilum.
OX NCBI_TaxID=1781255 {ECO:0000313|EMBL:OEJ73314.1, ECO:0000313|Proteomes:UP000095472};
RN [1] {ECO:0000313|EMBL:OEJ73314.1, ECO:0000313|Proteomes:UP000095472}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IPPAS B-1220 {ECO:0000313|EMBL:OEJ73314.1,
RC ECO:0000313|Proteomes:UP000095472};
RA Sinetova M.A., Bolakhan K., Zayadan B.K., Mironov K.S., Ustinova V.,
RA Kupriyanova E.V., Sidorov R.A., Skrypnik A.N., Gogoleva N.E., Gogolev Y.V.,
RA Los D.A.;
RT "Draft genome of thermotolerant cyanobacterium Desertifilum sp. strain
RT IPPAS B-1220.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEJ73314.1}.
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DR EMBL; MJGC01000092; OEJ73314.1; -; Genomic_DNA.
DR RefSeq; WP_069969077.1; NZ_MJGC01000092.1.
DR AlphaFoldDB; A0A1E5QFF6; -.
DR STRING; 1781255.BH720_20475; -.
DR REBASE; 172453; M.DspB1220ORF20475P.
DR OrthoDB; 564694at2; -.
DR Proteomes; UP000095472; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000095472};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 37..211
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 362..483
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 546 AA; 62255 MW; 39789AA91E4010FE CRC64;
MQVHQTQAIG VCYTPEAIAQ SIAIDTLDLL FASQTPQQIQ QIAILDPACG EGVFLRCAYR
YLHWWYTRHS PQPLSWQQCQ AIVQTHLFGV DIDRVAIAKT QQFLQQEVWQ SCQSSLPFNL
DRNVKWGNAI LEFDWHLEFP QVFDNGGFDA VIGNPPYADA KWMSHHVPQW REYCTQHYQA
ASGNWDLFCI FIELALRLCK PQGLTSFIVP NKLASARYAA STRRLLSQEN CLLQVRDYSS
IPVFPGAVYP VVYLAQKRSP TLQDAVRYEK MQLNSDRQIQ TGDTHDLAYR RFTRSPKQPW
QLSIPDATVV AIDRLQNQFP PLSAIADVLG AATVAEAYHI QALIREGNSD RLDLKLVNSG
TIDRYQFLWG EKTLRYLGDN YRYPIIPQDA LSELPPRRLE QAKCSKLVVA GMTKVLEAAI
DLNGDVLAGK STCIIFSSLD LRYLLALLNS QFMTFYYRTV FGGDRLQGGY LRVGVAQLRS
LPIVIAQESQ RDRLIHQVNR LLELYPQLSA TQATPIRRQI QALNRQIDEQ VYQLYNITAD
SLRAPR
//
