ID A0A1E5QNB3_9CYAN Unreviewed; 1568 AA.
AC A0A1E5QNB3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=6-deoxyerythronolide-B synthase {ECO:0000313|EMBL:OEJ76169.1};
GN ORFNames=BH720_06360 {ECO:0000313|EMBL:OEJ76169.1};
OS Desertifilum tharense IPPAS B-1220.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Desertifilales; Desertifilaceae;
OC Desertifilum.
OX NCBI_TaxID=1781255 {ECO:0000313|EMBL:OEJ76169.1, ECO:0000313|Proteomes:UP000095472};
RN [1] {ECO:0000313|EMBL:OEJ76169.1, ECO:0000313|Proteomes:UP000095472}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IPPAS B-1220 {ECO:0000313|EMBL:OEJ76169.1,
RC ECO:0000313|Proteomes:UP000095472};
RA Sinetova M.A., Bolakhan K., Zayadan B.K., Mironov K.S., Ustinova V.,
RA Kupriyanova E.V., Sidorov R.A., Skrypnik A.N., Gogoleva N.E., Gogolev Y.V.,
RA Los D.A.;
RT "Draft genome of thermotolerant cyanobacterium Desertifilum sp. strain
RT IPPAS B-1220.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEJ76169.1}.
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DR EMBL; MJGC01000041; OEJ76169.1; -; Genomic_DNA.
DR RefSeq; WP_069966328.1; NZ_MJGC01000041.1.
DR STRING; 1781255.BH720_06360; -.
DR OrthoDB; 499075at2; -.
DR Proteomes; UP000095472; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0008897; F:holo-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.470.20; 4'-phosphopantetheinyl transferase domain; 2.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR008278; 4-PPantetheinyl_Trfase_dom.
DR InterPro; IPR037143; 4-PPantetheinyl_Trfase_dom_sf.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01648; ACPS; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF56214; 4'-phosphopantetheinyl transferase; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000095472};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 12..469
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 1568 AA; 173056 MW; A64F44EDA034A2A7 CRC64;
MNVSHLSFSS SPSDIAIVGM SALFAKAANL QAYWHNILHQ VDGVTEAPDS WAHPYFDPNS
TENNRIYTRK GGFLGDLAQF NPLEFGIMPT AVDGGEPDQF LALKLARDAL QDAGYDQKPF
NRQKTGIILG RGTYVNRGYT TLLQHGMIVD QTLELLQQLC PHLDKQTLSS VRQGLKESLP
PFSPEMLPGL VPNNVTGRIA NRLDLMGPNF IIDAACASSL IAVKLAMQEL LTHRCDMVLA
GGIHASTPPQ IYMIFCQLGG LSHSEIRPFD ASANGTLLGE GLGILVLKRL ADAQRDRDRI
YAVLKGVGSA SDGKALGLLA PRLEGEVLAL ERAYQTSGVD PGSIGLIEAH GTSIPLGDRT
EIQALSQLFG PRQGQMPPIA LGSVKSSIGH CIPAAGVAGL IKTALALYHK VLPPTLCEQV
NPALGLEQTP FYINTRARPW VHGNPHLPRR AGVNAFGFGG INAHAVLEEY REPSPTASPL
ALRPPNELLI FSGDERAEFI ERLKTTLSHL QTSPPPTLTP LGYQLSQTPS GFHRLAIIAS
DPADLAVKLA LALDKLDSQP QRFQTRNGIY YGQGKPPGKV AFLFPGEGAQ YTNMLADLCL
AFPQVREWFD FLDQTFWQER PYRPSQVIFP PPTSLTTAEE LFADRQLFAM DIGSETVFTA
SMALYELLEQ CQVPCDAMVG HSTGENTALF ASGTAQIESR AQLGELMRYL NQLYQELETG
DRIPKGALLA VGAISPDQMA QTLAAAEGRL HWAMDNCDNQ LVLFGSETEI EAITPPLKAQ
GGICLRLPFD RAYHTPLFAS VAEAFRTFYE ALNIRPSKIP LYSCATAEIF PCEPAAIRAL
ATQQWSSRVR FRETIETLYS RGFRIFVEVG PSSNLTAFTN DILRGKDALA VASNNRRRPG
LEQLQHLLGR LFASGVNVNL DIWYRNADTQ VSATPPAATP LSLNMPAMHL SETLVQNLQD
KLHPPQELPS EPVAYSGQTA VVSAYFDLMQ DFLKSQEQVF SQFSPHPATV CCAYPLLGEI
LSQDESYLEC DRIFSLDPDC FLAHHTLGGQ PSQWQPDLLA LPVLPFTFSM EIIAEAAHYL
LGGQYTVVSL HNLRGYRWLT LDEGNLHLCI RAQRQEPTPE GESVWVRLFQ QQTVGPETGL
LVFEGEVRLS PQALSPPPPQ PFSLNAPKRP RLADADLYQT GMFHGPLLQG VKHLRQWSEE
GIEADLQVLP VEEFFSEARV PQFQLDPGLL DAAGQLVGYW LTEQFGPDFN CFPFQVNAFY
QYAAPLPAGS LVDCRGTIRF TSPQQIAADF ELLDATGQVI ARLEQWQDRY FAMPTAFSEC
RLHPQTAYLS EAWMQAETGL TLRRIPAFGD HFLDEAWAIW QRVLVHLMLT PTERETWYRF
PPGKRRKDWL LGRIAAKDVI RQWAAEDWGV VLAPIDIEIG TTDLGKPFAE IPLLDTILPD
LSIAHTQGEA IAILAADAES IGLDLERLDV RRDWSLLQGA FSESEQILLQ SLSTAQQTTA
LLTFWCAKEA AAKAAGTGLM GVPRRWQAVS YSATENQMEI EFEGYKFIVQ WWQTATHLLA
VCQSPVRS
//
