ID A0A1E5R178_9ASCO Unreviewed; 530 AA.
AC A0A1E5R178;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Acyl-CoA desaturase {ECO:0000313|EMBL:OEJ80651.1};
GN ORFNames=AWRI3579_g3957 {ECO:0000313|EMBL:OEJ80651.1};
OS Hanseniaspora osmophila.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycodaceae; Hanseniaspora.
OX NCBI_TaxID=56408 {ECO:0000313|EMBL:OEJ80651.1, ECO:0000313|Proteomes:UP000095728};
RN [1] {ECO:0000313|Proteomes:UP000095728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AWRI3579 {ECO:0000313|Proteomes:UP000095728};
RX PubMed=27856586; DOI=10.1128/genomea.01287-16;
RA Sternes P.R., Lee D., Kutyna D.R., Borneman A.R.;
RT "Genome sequences of three species of Hanseniaspora isolated from
RT spontaneous wine fermentations.";
RL Genome Announc. 4:E01287-E01287(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000256|ARBA:ARBA00009295}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEJ80651.1}.
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DR EMBL; LPNM01000011; OEJ80651.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E5R178; -.
DR STRING; 56408.A0A1E5R178; -.
DR InParanoid; A0A1E5R178; -.
DR OrthoDB; 2012205at2759; -.
DR Proteomes; UP000095728; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016717; F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd03505; Delta9-FADS-like; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR015876; Acyl-CoA_DS.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR005804; FA_desaturase_dom.
DR PANTHER; PTHR11351; ACYL-COA DESATURASE; 1.
DR PANTHER; PTHR11351:SF31; DESATURASE 1, ISOFORM A-RELATED; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000095728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 65..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 409..492
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
SQ SEQUENCE 530 AA; 61888 MW; 3468E57BFB2A90B1 CRC64;
MDSERNDIET LREAPAIPSF DYTGFLDDPE IKKFLDPAHV NKLKNSAKHD PYFIHLFKKI
NPSKAILNIV IPLYCLFILI FNKPPISTAS NTDQIQPAKP LTANFYLQYT KSDIFLGVIV
INYLLTLFAF FVGYHKYFTH HTFQTDSKAL QLIFAIFGAS VGVGSIWEFS SQHLLHHFHT
DNEKDPFNAK HGWLFHMWGH NLFYGNKKAE NAYFQMMKSS NDKRNLVFLH KKRKDQGNFN
EFMIWQHRNY SYIVLLMIFV LPMIVSRLLH VNMWSCIFYL GLCKMSIIQQ QWFLGETLGH
HWKVNSCQSY DDSNSSMNCG FQWFWAFFTF GETQHNFHHE FPGDYRNSNK WYVLDFQKWI
IYVLYQIGLV TRLHTTNSKQ IRQAEIQQEQ RNLDKLRKTL MWGVPIEKLP IITAQQFSAM
AEQEYKVRKR ALVCVEGIVH DVTPWVKDHP GGPSLIEMAI GKDASDAFNG GVYLHSKAAR
NLMANMRIAV VVSNKDGVWG KSSQDDNDQY RLRLERNRRR NKTYYAAGAA
//
