ID A0A1E5R1G4_9ASCO Unreviewed; 729 AA.
AC A0A1E5R1G4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN ORFNames=AWRI3579_g3978 {ECO:0000313|EMBL:OEJ80736.1};
OS Hanseniaspora osmophila.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycodaceae; Hanseniaspora.
OX NCBI_TaxID=56408 {ECO:0000313|EMBL:OEJ80736.1, ECO:0000313|Proteomes:UP000095728};
RN [1] {ECO:0000313|Proteomes:UP000095728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AWRI3579 {ECO:0000313|Proteomes:UP000095728};
RX PubMed=27856586; DOI=10.1128/genomea.01287-16;
RA Sternes P.R., Lee D., Kutyna D.R., Borneman A.R.;
RT "Genome sequences of three species of Hanseniaspora isolated from
RT spontaneous wine fermentations.";
RL Genome Announc. 4:E01287-E01287(2016).
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEJ80736.1}.
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DR EMBL; LPNM01000011; OEJ80736.1; -; Genomic_DNA.
DR STRING; 56408.A0A1E5R1G4; -.
DR InParanoid; A0A1E5R1G4; -.
DR OrthoDB; 2712461at2759; -.
DR Proteomes; UP000095728; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000095728};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 95..302
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 391..725
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 729 AA; 83045 MW; 914D578AF2BE8158 CRC64;
MSTTLYSDSL GLPKTDPKLW RLQTDKLGKE IWVYLSPEEA ENTPQSXFVQ DLLGTADLED
FLKQGPDYTK QADTVGDALQ KGANYFKLLQ DXDSGIFPCQ YKGPMFMTIG YIATFYIAGL
EIPEPVRLEL IRYIVNTAHP VDGGWGLHSV DKSTCMGTVL NYVSLRLLGL PKDHEVCKRS
RLKLHKLGGA IGAPHWAKIY LALLNLYDWR GVNPAPPELW MLPYQVPIHP GKWWVHTRAI
YLPVGYLSAL KYQMELNPLL ADIXSEIYTK PFESINFAEN RNTVCETDLY YPHTKVLDVL
NNCMVFYGDH IRPNWLLKKS NAYTYELIKK DLYNTADLTI APVSFAFVCI VTMIEEGAKS
EXFLNLVEGW KDVLAHGPQG MCVMGTNGVQ VWDCAFFVQY FFVAKLAELP EYAPYIEKAY
XFLCDSQFDT ECCEGSFRDK RKGGWPFSTK TQGYTVADCT AEAMKAIIMV RNSATFEHLR
DYITDERLYE ACDVLLSLQN VGSFEYGSFS TYEKIKAPLS LEHLNPAEVF GNIMVEYPYV
ECTDSSVLGL TYFHKNYDYK KEEISHRIKI AIEYIKNAQR PDGSWYGSWG VCFTYAGMFA
LEALSTVGET CANSEVARKA CDFFVQKQRA DGGWSESMKS CELHHYVETE QSLVVQSAWV
LIGLLLAEYP DXKIIDAGIK FLMSRQDPQG KWHFEDIEGV FNHSCAIEYP SYRFLFPIKA
LGLYKXRYL
//
