ID A0A1E5RJJ5_HANUV Unreviewed; 3105 AA.
AC A0A1E5RJJ5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=AWRI3580_g2653 {ECO:0000313|EMBL:OEJ87091.1};
OS Hanseniaspora uvarum (Yeast) (Kloeckera apiculata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycodaceae; Hanseniaspora.
OX NCBI_TaxID=29833 {ECO:0000313|EMBL:OEJ87091.1, ECO:0000313|Proteomes:UP000095358};
RN [1] {ECO:0000313|Proteomes:UP000095358}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AWRI3580 {ECO:0000313|Proteomes:UP000095358};
RX PubMed=27856586; DOI=10.1128/genomea.01287-16;
RA Sternes P.R., Lee D., Kutyna D.R., Borneman A.R.;
RT "Genome sequences of three species of Hanseniaspora isolated from
RT spontaneous wine fermentations.";
RL Genome Announc. 4:E01287-E01287(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEJ87091.1}.
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DR EMBL; LPNN01000005; OEJ87091.1; -; Genomic_DNA.
DR STRING; 29833.A0A1E5RJJ5; -.
DR VEuPathDB; FungiDB:AWRI3580_g2653; -.
DR OrthoDB; 1969388at2759; -.
DR Proteomes; UP000095358; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF72; SERINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OEJ87091.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000095358};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2693..3003
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3073..3105
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 3105 AA; 362228 MW; 804505DB25110F91 CRC64;
MSDQNASNLS DDSNFEEWLN EESLVEENVS KEASAIEKTL ICIKDRVLNR NISTIKEKKT
IMNLFTSAIN TSASPALYKK VKKEVVMETW KVLINFFNNL NKKNISDLIK IKSQYITENG
LDEYLVNKDS IIDKSITVRM TELLDFLNAL AKLLDVAKHN FIDGEGFKDL ISWIIEQVIG
EDFTVFGDYV ENFYDLNGKY SELYRYHYQN MLNVVLINPQ ALDRNLYDKL LESQYLIFTE
ENTSRFSSCY NLSIKILSNV MKHRLLGKVH GTWEKLLVNA FRKFLMDTYT VKKVNEDFIV
ITQYMLEWSF VFDNENYGIT SRVLIDNFIK AKKFDDTVFN FLKNYLDFLP YDVEYQVTFN
KNNFFLDDML RLLKFLLLNV IEVHNKDTDL IPETYTFKEF PKEGSDLRIY EYEYVNXTDG
LNIIAEYIGI YFYLKEKIKL FDDTSEKDIF VEDKSNIVEP LENSRVKKDV MNYVMPLLRH
SISLCEFIGS LKKACEESIN FEKIVPVITA VLLKYQLNCP IDYNFVRHVN TNRNLGLHHK
YMLNSSLLFN VMQCKSDNCI SAVKKDIAEA LFLPYIEALS RLNENIPSMS YFVGLFTGWI
NREKTALNHE QLVKVRIKVI DILKNIRTQS PIGDSLEIFK VWKNFCLLIP YVDNNILQND
LAERESLIFE GFDFTTXXDS WLDKNTESQN KDLNSLKNYE ISNGLTTFEL ILKDWLPIAL
ICEDALSFSN FFYWGYSQDT DTYIQDAFYA QQKTMDLCYS YSNSYKQRCN VCKEETTDNF
RNGLVNNNKG STTLPFIKSK ILFKNNDNMF LQNFLINISL KRKSKLMSVN RKVYLXENSC
SNKSCPQYTA SYNSDVYEGR GMFRSYKSLF YLIKYAEKMY VDNTNNNGLG WMRLLIYLSE
DTEKMSGKIH SQLLSLIDRL VLPKKKYTAD YMATIISNYD IYSIEYLNPK YFSIFECLGM
GSEKAAFYNV MDNENDLXYF SQLFQDISLQ PFHQLTDRFT WVSFKKIFLE SSTFWKSANQ
FDLFLETFFN KVSSLNSQEK SAIVNVLITN IKDDINSEKC HDIHMLKMFL LIVGKILASS
ILMEGQSKNK TLKLWISIHD MSYSGIYQSG TIESLESLFK RLDYKSQKSV LVNIQQSLIE
KQDVQIQFEM LTSLSKISKS LMVFCFKKVL TLLNKKTYIL FELMLSELCK WYNFKSKRKL
FAALNYDIMV VLMSDLLETD LTIVPDHVIL SLNALFDEPT LLNVXEICEK LLKDENLAHI
FVCSCLILTT NIDKLKALXI LEFQSNDVIK ADVLYSSFKK ESSICVVDQL RLTKVETLIP
KECYYHTKFK EQLKLLDTSS LANIASGILA VCPHFDRSVL QDALYESKPI SFLKLSSLSV
PELLLADPVL XKXINFYSSL MIELPILXTL TELGGCFSVY EVGISAMRKL KIVYLLILGL
CQDQSVLDRV TLNFLEYIIK IDNFESLFDS FKSFLFILMS KVKSKKLSFE IKIKIMSKLY
SVKNKLDLDH KKAIHQFVEG KGLPHPLFYQ MYQFIFDDPE DIDVTMQHTS LKPVFLKVTS
AANCLEDLNV FMTDLILKTR MSIDTAAFLM LDFSQETFSM VNWENISSLF AARLLEDFKM
KKTAEVTKME KNHLSLISES LLELKASTKN INDLLELTLL SLSFHLSEEY QDADEDLEED
FFCSLSKLNL EFNFEEAVTM TDFTDIIDYE TETSNINFGG IDGVDNDSYL DWLHNLWKHL
TLHFSENSIF NFIWVVDRKF NSNHLKHKFL YSVIVSLSTV MDKSVISEWG KFFNFALTSN
FNNIHEFRLK ASALLKIFIL IRSLGYDEDK VIQQSFKSKY KHLYDIFVLE DMVDLCLALN
DHELAFMLAE EDIKLWKKTS IWKNIFKGLN SEYDIFLKTS IPMELELTEY LNNSKEYSKD
IRFSQSVLGF NLASLETNYQ QNICLKNIQY SLENQGEHYL AKSLISQEKE DYINFNQKFE
SYYTELQNWD IPLSDSCNEE AYLFNYSKSK LLFDKEYNHE VDTYGYGLIK NLMLNNKKNI
EEKVLGLNDI RLNILSDISL EKTNMLSNSF KASCVPTSEF FKKRNKSDLF XTISSGLVAF
KDILSYLDNQ DQYKVLKYYN ENLKILVYSN VFADNLKSAF KVDQNSPGYD EMQIPSKQML
KELGLLHLLN LSYMMERAEN EYFESFNWPI KELIRCQKFI ELLNTYYFDE HKEWEDHVNL
MNLICRWHSG DKISSFYHLN NMLERDDNVG NYDFKNILKI NKIKWTLESK SETLKTTWTA
YHQLVNDIKT THKYEDNLFS YHSKDIYTIN AYYFGILNAK MDNYNPDYKE XDTLLRKHAE
IREQQISCKK YLTLFQNNAD KKKKMSETLK VISTNEKFVA ERYNEIQRSM KNNKNEIINM
TVCLISILSD QICTLGNYAY KETENTDMFF SLWFDLINFF SKDYFDIDKL GNKEVEKLQI
ENIKVNFKQI LEFQTIADMP MNKENKEANW IKNRCTIIGW KDILKKWVDS IENILSSNRA
ACLPWLGTIF AKISTGHIEV NENCNIFSVL LECYLNKIII SCIEEYPDYS IHLANSYMNY
SSDNNDKARL RSSLISQLMT SLVVKNSKLM KMADDYKSFS NIIKDLSLTP TLKKVARISL
TEKQNCKVIF KKTPDEIFEV FSEKRNIINP LVDYVKLVKS NSDLKQYHIV NIGDMINMST
SGLSRPRIFN FQLKNGTQFK VLAKGNDDLK SDEIMLKVMR KIDNLIFKEK EGTDLKYRLL
TYQVFPMGHN FGMMEFIKDV SSLNDILKPM HKDDEISQEE LRKKMDASYK AKDTSQARVK
VFTDMCXLVT PRFNQFFRIN FLSPESWYKA KKTYAMSLAI TSLIGYVLGI GDRHMSNVMM
NCQTGDLVHI DFGITFDSGK KLAIPERIPF RYTADMRDAL GIYGHYGAIN RFFEDVYSTL
RKNHIVVLLS LMNLKLDPLY KWSLEVSTKK LEAMFDLSDD DLDDRDSSYE LQDKIYDENY
EDWKHKAKKV AIKPMKNGKT TELFDVVVKP TESLNVKTAL LVLRKSKIAY SISEEYSKKC
LDTVSDKILG GKDRQSVESC VQRLLNEAQS NDNLGLIFCG WCPFY
//