ID A0A1E5S1F8_HANUV Unreviewed; 1348 AA.
AC A0A1E5S1F8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=DNA repair protein RAD50 {ECO:0000313|EMBL:OEJ92906.1};
GN ORFNames=AWRI3580_g483 {ECO:0000313|EMBL:OEJ92906.1};
OS Hanseniaspora uvarum (Yeast) (Kloeckera apiculata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycodaceae; Hanseniaspora.
OX NCBI_TaxID=29833 {ECO:0000313|EMBL:OEJ92906.1, ECO:0000313|Proteomes:UP000095358};
RN [1] {ECO:0000313|Proteomes:UP000095358}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AWRI3580 {ECO:0000313|Proteomes:UP000095358};
RX PubMed=27856586; DOI=10.1128/genomea.01287-16;
RA Sternes P.R., Lee D., Kutyna D.R., Borneman A.R.;
RT "Genome sequences of three species of Hanseniaspora isolated from
RT spontaneous wine fermentations.";
RL Genome Announc. 4:E01287-E01287(2016).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEJ92906.1}.
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DR EMBL; LPNN01000001; OEJ92906.1; -; Genomic_DNA.
DR STRING; 29833.A0A1E5S1F8; -.
DR VEuPathDB; FungiDB:AWRI3580_g483; -.
DR OrthoDB; 5477220at2759; -.
DR Proteomes; UP000095358; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000095358};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 6..266
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT COILED 224..275
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 624..696
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 863..897
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 926..965
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1348 AA; 156454 MW; 7679023FA5762C1D CRC64;
MSSIEKLSIQ GVRSFSPNSI EEIKFQTPLT LIVGTNGSGK TTIIECLKYA TTGDMPPISK
SNGFLTDPQF YNITTVNAMV KLHFKNLSNK LVITRNSSLS VDPTSATKKS TFKTLTKTLE
DYNMITNKKI THEPSKTIAI EDILNKYIGV SKPILDYVIF AHQEDSLWPL SDSNTLKKRF
DEIFEVSRFT KELQNLNAVK KNIKVDIKLR EGDLINCKDN LKKFHALKDR IQRLNISLDQ
YDAERIQLEE KLKEIADAQQ NLMNINQSYM DIVNEFTQLS STKXSMLRQL HDMSKTYPRI
EQRXSKENLN TXLXSVNENI ARVNENINTK YLNDLKKLNK DLDSCNFNIV SISTKLGGLQ
QSEKSYFLNK QEMNNLLEQF DYLNTNNKDE IKQIIDKKQF EISQFLKKIK VETDDLKSII
NQCETEIAKL SFENKHIDMQ TSGLNSELKV LQSKLDLIES DILYRNESEQ KSVEEEHTKL
IMEINTALKN ELSEDAIEXK QQKLNAKMVX VKEXDENLES VRKSILSAKQ GSEKSNLFHF
RKNDLLQTLQ NTPIKNFFTV ENYDQYENLI NSFESYAKNL KLDTFIDIEE LCENLENFQM
KYSDVLGNQI VIKNKIFSNL EISKRKLELV NLDVNKNNEE IQRNEALMKD LEKSKSQYED
ILYDKLDLSL DDQSILQNYE DNLQILKENL NDINESIGMN TGMIQVFEHA RKSILKKKCC
NICKTSFEND EEKMXLALSY VDKKINTDVD KTNKEKEIAQ KEYNIYLKLR XSVVNFCDTR
QKIISSKQQY EILLSSQDLL KKQFVELSKL VXDDEEFIXK AEQCIQSLEK CNNALRDISI
QSSKLKDTKL ELDKSHQEQP QDINSLAAEQ DKLSARRTHL XQEITXLTRD ISNLKELKVX
KEFKKTKYEA EILRSKELFN EANSXKEQLS NKKQILNKNQ ETLKQNQKKI KESKNNCSEY
KLKLNXFEIK NGKEIKNKEE ELNSLKNKTS RLFDYLLPEM KKFEDEEQHE LLSNTTKLSD
YKEQSXAIKN SIHQTSLLIE KGRKELEIFK EETKVINQVL QYLSLKDEYI LVCDKLSNIN
EQEVLEYQKE YSSTAQELNM AFTDISSEIS SKKGEIRQIK NQXETDLKTI DHDYADIENK
YHEINCNSKT LLNMEHDLDI AGKVIEMSIM NFHSKRMEEI NVLLDELWRT TYKGSDIATI
KIVTEKVKKN STASGSNIDS YNYKVVMYKD SLEIDMRGRC SAGQKVMACI LIRLALAETF
GVSCGVITLD EPTTNLDQEN SEGLAESLHR IIESRRFQQN FQIVIITHDE NFLKFMNAQD
FTDGFWKVSK DNNLASKIEW KSIENLIQ
//
