ID A0A1E5UHE0_9FLAO Unreviewed; 617 AA.
AC A0A1E5UHE0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN Name=topB {ECO:0000313|EMBL:OEL12304.1};
GN ORFNames=BHF72_1057 {ECO:0000313|EMBL:OEL12304.1};
OS Cloacibacterium normanense.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae.
OX NCBI_TaxID=237258 {ECO:0000313|EMBL:OEL12304.1, ECO:0000313|Proteomes:UP000095601};
RN [1] {ECO:0000313|EMBL:OEL12304.1, ECO:0000313|Proteomes:UP000095601}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRS-1 {ECO:0000313|EMBL:OEL12304.1,
RC ECO:0000313|Proteomes:UP000095601};
RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEL12304.1}.
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DR EMBL; MKGI01000005; OEL12304.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E5UHE0; -.
DR STRING; 237258.SAMN04489756_102161; -.
DR PATRIC; fig|237258.4.peg.2064; -.
DR Proteomes; UP000095601; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:OEL12304.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000095601};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..134
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 617 AA; 70425 MW; 5B3AB081D3F3A637 CRC64;
MKLCIAEKPS VARDIAKVLG ATTPKSGYME GNGYCVTWTF GHLCTLKEPH DYAPEYKAWN
LFLLPIIPKN FGIKLINNTG VERQFKVIES LVKECEEVIN CGDAGQEGEL IQRWVLQKAK
CDKPVKRLWI SSLTEDAIKE GFEKLKSAED YKNLYLAGNA RAIGDWLLGI NATRLFTKKF
GGNKAVLSIG RVQTPTLAML VKRQKEIDAF VQKDYWELKT KYREVVFTAA IDRLQSAERA
EKGLEYLKQN LFEIIAFEIK EGKEKNPRLF DLTGLQVEAN KKYGFSAEST LNYIQSLYEK
KHTTYPRVDT TYLSENLYPK ISGILRSMNF YSDLTAPLLE APIPMSKAVF DDAKVTDHHA
IIPTEIPPTS NLTREEKLVY DLVAKRFIAV FYPECKISNT LVEGQVGTIN FKASGKQILE
PGWRIVYAKD QKETAEKEEK NEEQLIPEFT VGEKGEHEPF VHQGRTTPPK PYTEATLLRA
METAGRQVED EELRELLKNN GIGRPSTRAN IIETLFKRKY IEKKRKNLFA TQTGIDLIDT
IEDELLKSAE LTGEWEQKLR KIEKGEYEAQ KFKEELIEMV TQLTKKVIDS KGKVISFQEE
KTTKTKTKKK KDTNPGD
//
