ID   A0A1E7F093_9STRA        Unreviewed;       459 AA.
AC   A0A1E7F093;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:OEU11611.1};
GN   ORFNames=FRACYDRAFT_192026 {ECO:0000313|EMBL:OEU11611.1};
OS   Fragilariopsis cylindrus CCMP1102.
OC   Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC   Bacillariophyceae; Bacillariophycidae; Bacillariales; Bacillariaceae;
OC   Fragilariopsis.
OX   NCBI_TaxID=635003 {ECO:0000313|EMBL:OEU11611.1, ECO:0000313|Proteomes:UP000095751};
RN   [1] {ECO:0000313|EMBL:OEU11611.1, ECO:0000313|Proteomes:UP000095751}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP1102 {ECO:0000313|EMBL:OEU11611.1,
RC   ECO:0000313|Proteomes:UP000095751};
RG   DOE Joint Genome Institute;
RA   Mock T., Otillar R.P., Strauss J., Dupont C., Frickenhaus S., Maumus F.,
RA   Mcmullan M., Sanges R., Schmutz J., Toseland A., Valas R., Veluchamy A.,
RA   Ward B.J., Allen A., Barry K., Falciatore A., Ferrante M., Fortunato A.E.,
RA   Gloeckner G., Gruber A., Hipkin R., Janech M., Kroth P., Leese F.,
RA   Lindquist E., Lyon B.R., Martin J., Mayer C., Parker M., Quesneville H.,
RA   Raymond J., Uhlig C., Valentin K.U., Worden A.Z., Armbrust E.V., Bowler C.,
RA   Green B., Moulton V., Van Oosterhout C., Grigoriev I.;
RT   "Extensive genetic diversity and differential bi-allelic expression allows
RT   diatom success in the polar Southern Ocean.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; KV784366; OEU11611.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1E7F093; -.
DR   EnsemblProtists; OEU11611; OEU11611; FRACYDRAFT_192026.
DR   KEGG; fcy:FRACYDRAFT_192026; -.
DR   InParanoid; A0A1E7F093; -.
DR   OrthoDB; 2346200at2759; -.
DR   Proteomes; UP000095751; Unassembled WGS sequence.
DR   GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:UniProt.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11808:SF15; CYSTATHIONINE GAMMA-LYASE; 1.
DR   PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 2.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095751}.
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         257
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   459 AA;  50323 MW;  9D05315DAD2761B9 CRC64;
     MATILSHAGI TTTSCDNSGE ERENHPMSPP LHTATTYTRP PDGIYKDSDS IYARMDNPTR
     LLLEKNIFDL ECTNLLYRYR KNKDDDDDEK KRDNDDNGTR IPLLPLLCTT TTTCYSSGMQ
     AVTSILLAHS SSPTNMTVLI PTDVYHGVRS LLSGVFSRHG IHVRGINMSS SGGNEEDIHN
     HDHNHDLHNI IVWMETPSNP KCEVVDIKTV CDKVRSVGER WKNVIKITTV VDGTMSSPVL
     TRPLELGADI SFHSGTKYLA GHSDALIGTV TVSPTSHRGR TLHPLIKAVQ ISSGGVASPW
     DSWLTLRGMR TLHLRVERQC QSAMKLADYL EEKRIKTTIS GVWAVHYPGL PSHPQHDVAT
     KQMNNGYGGV LSFELEDEIA ATAFAGAVRI AQRATSLGGT ETLIEHRASI EPPDQRTSPP
     GLLRVSVGLE DVNDLIHDFD TAFAIVKQVL SSSSSSSSG
//