ID A0A1E7F9L8_9STRA Unreviewed; 1492 AA.
AC A0A1E7F9L8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=FRACYDRAFT_241079 {ECO:0000313|EMBL:OEU14533.1};
OS Fragilariopsis cylindrus CCMP1102.
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Bacillariophyceae; Bacillariophycidae; Bacillariales; Bacillariaceae;
OC Fragilariopsis.
OX NCBI_TaxID=635003 {ECO:0000313|EMBL:OEU14533.1, ECO:0000313|Proteomes:UP000095751};
RN [1] {ECO:0000313|EMBL:OEU14533.1, ECO:0000313|Proteomes:UP000095751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1102 {ECO:0000313|EMBL:OEU14533.1,
RC ECO:0000313|Proteomes:UP000095751};
RG DOE Joint Genome Institute;
RA Mock T., Otillar R.P., Strauss J., Dupont C., Frickenhaus S., Maumus F.,
RA Mcmullan M., Sanges R., Schmutz J., Toseland A., Valas R., Veluchamy A.,
RA Ward B.J., Allen A., Barry K., Falciatore A., Ferrante M., Fortunato A.E.,
RA Gloeckner G., Gruber A., Hipkin R., Janech M., Kroth P., Leese F.,
RA Lindquist E., Lyon B.R., Martin J., Mayer C., Parker M., Quesneville H.,
RA Raymond J., Uhlig C., Valentin K.U., Worden A.Z., Armbrust E.V., Bowler C.,
RA Green B., Moulton V., Van Oosterhout C., Grigoriev I.;
RT "Extensive genetic diversity and differential bi-allelic expression allows
RT diatom success in the polar Southern Ocean.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR EMBL; KV784360; OEU14533.1; -; Genomic_DNA.
DR EnsemblProtists; OEU14533; OEU14533; FRACYDRAFT_241079.
DR KEGG; fcy:FRACYDRAFT_241079; -.
DR InParanoid; A0A1E7F9L8; -.
DR OrthoDB; 4338126at2759; -.
DR Proteomes; UP000095751; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd21036; WH_MUS81; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR045840; Ariadne.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR047417; WH_MUS81.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF19422; Ariadne; 1.
DR Pfam; PF01485; IBR; 2.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000095751};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT REPEAT 694..727
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 952..1231
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 956..1008
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1435..1492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 288..315
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..634
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1435..1454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1455..1492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1492 AA; 168440 MW; 606C243A657D78DF CRC64;
MAASSSSSSS IISTKNQRHK KPKNKHKQQC CNNRNDGNNN DYYYPDVLSL TTTTTTTTTA
AAASLTYNFV VRSLRRRLWK AFCEDDCISA LRAYQATLSD FRCWLEEEEE LRRQHQREAV
SSSTTTADSN PFNNDHYMKK LKIRSGAFGI LMAFHHSQSS VLKMNTICEE AQRFCDDQMD
SNFHKGRMYG AWASMKTLTS HHLVSDSGFS SGYLSGRILR DHPHDFSLTK EGELFIKALL
TNRPEAAAAA GQVIGLGSRP SAVDAVAAAA AKEENEKHKT DDDDDDYELA LQRQRRQQED
ELEQQTESVN NIKSIEKLLG GSNVPILQSQ MNPSEFFIAD DYLSPYDYCT YEERRKKQQV
LPTAEQQHQQ YLLLEEEERQ KRRIRQLRLS SKPRVVAFRR LFSSSSRSST ATATATAHRQ
NNVEDNDSDF GLVNSLVTDA LNEHDNNNNN DGEVVTTTAA NTISPSSSTE SNNNENNNNN
SNANANTNDN TNDNVYMTTP LHEAARLGFG DFVRVLLANN NAGGADVNEK NGYIRTAIHM
CAGGVTIEEE RLINAQQIIA QTQMTTIGIR STVIPKDLLE LLRQDPATAT TTTTKKRNNN
RSSKGSMTKR RSLIERVLFN RNRKKNDSTT EDTDGSNHRT ASSSSSRDIK IRIKPDSKRL
NELVTSRMDA MMALLSWIQK DSCQGPSINA VDNNGRTALH YAAELGRTDI CMAILSNFGV
ILTVVDESSR TPCEVAALQG HSTLAAQLEA RALLYVDPYG LDDMMDNMMA VSPLSSSGNS
GGNNNSKKLV PPFRWFQTMS MNEVSQSRMT WLLEIRRKLI HISNDSDDNN NISMEDKKPS
SVPNLKNGPS YTTWSDNLNL QPYIGASFKS NTNATDHEHR HSETELCRHD IIPPAAADLE
RYLAYHNWER SAAIDAFRKD PKGALATAGV KFIKRGNGDN NIVKANDADE EESRLCTICY
DDDVDKENWM QFHSSCNHGF CKDCLLDYVK QCAVNRTPMH SITCPSHDCD QGLSFLDVQS
LLLEKDHTDT FERIKEASTE SFITSSSNYK YCPHPGCEGV VHRLDQPEWT NAGFDKTFLD
YTGAVCTIIT DRAKIGDDCT LTYEGVEDLD YNNCRSTRQP PKAHRFCFSC LEPVHWPLKC
ERMKEWKERI TEEIGEIDTP NGDFNELAQN MWLKANTRPC PHCKAPIEKN DGCNHVVCKS
CSFEFCWVCM KAWYLHTIET TDGYFRCSIW EKDDSGKERD NHIDSLNGTE GYGTSIYTAR
QAWRKKQEMK RFLHHYSKYS AHEESSILER KMGDSVCTRL APVVEAAIAF DGSPLFNFGG
NGLSFVHNAF LELLECRSIL RHSYAFSYFR YPPSSSNELP PAVGYLHNSK RKEKARFERT
QSELEMLTEQ MSDIVGRSHI RATQVQVAYL TAGAAAKRVD FTNFMFQIYR EEKKEIDKQK
KRQAREEEGK KNHVSSSLEL SNDSPGQEEG SQTETFIAAM DNKNLQRTDA TH
//
