ID A0A1E7FEU5_9STRA Unreviewed; 635 AA.
AC A0A1E7FEU5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Enhancer of polycomb-like protein {ECO:0000256|RuleBase:RU361124};
GN ORFNames=FRACYDRAFT_225808 {ECO:0000313|EMBL:OEU16702.1};
OS Fragilariopsis cylindrus CCMP1102.
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Bacillariophyceae; Bacillariophycidae; Bacillariales; Bacillariaceae;
OC Fragilariopsis.
OX NCBI_TaxID=635003 {ECO:0000313|EMBL:OEU16702.1, ECO:0000313|Proteomes:UP000095751};
RN [1] {ECO:0000313|EMBL:OEU16702.1, ECO:0000313|Proteomes:UP000095751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1102 {ECO:0000313|EMBL:OEU16702.1,
RC ECO:0000313|Proteomes:UP000095751};
RG DOE Joint Genome Institute;
RA Mock T., Otillar R.P., Strauss J., Dupont C., Frickenhaus S., Maumus F.,
RA Mcmullan M., Sanges R., Schmutz J., Toseland A., Valas R., Veluchamy A.,
RA Ward B.J., Allen A., Barry K., Falciatore A., Ferrante M., Fortunato A.E.,
RA Gloeckner G., Gruber A., Hipkin R., Janech M., Kroth P., Leese F.,
RA Lindquist E., Lyon B.R., Martin J., Mayer C., Parker M., Quesneville H.,
RA Raymond J., Uhlig C., Valentin K.U., Worden A.Z., Armbrust E.V., Bowler C.,
RA Green B., Moulton V., Van Oosterhout C., Grigoriev I.;
RT "Extensive genetic diversity and differential bi-allelic expression allows
RT diatom success in the polar Southern Ocean.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Involved in gene silencing by neighboring
CC heterochromatin, blockage of the silencing spreading along the
CC chromosome, and required for cell cycle progression through G2/M.
CC {ECO:0000256|ARBA:ARBA00025513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU361124}.
CC -!- SIMILARITY: Belongs to the enhancer of polycomb family.
CC {ECO:0000256|ARBA:ARBA00008035, ECO:0000256|RuleBase:RU361124}.
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DR EMBL; KV784358; OEU16702.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E7FEU5; -.
DR EnsemblProtists; OEU16702; OEU16702; FRACYDRAFT_225808.
DR KEGG; fcy:FRACYDRAFT_225808; -.
DR InParanoid; A0A1E7FEU5; -.
DR OrthoDB; 1343374at2759; -.
DR Proteomes; UP000095751; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR024943; Enhancer_polycomb.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR PANTHER; PTHR14898; ENHANCER OF POLYCOMB; 1.
DR PANTHER; PTHR14898:SF0; ENHANCER OF POLYCOMB-LIKE PROTEIN; 1.
DR Pfam; PF10513; EPL1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361124};
KW Reference proteome {ECO:0000313|Proteomes:UP000095751};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361124};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361124}.
FT DOMAIN 46..121
FT /note="Enhancer of polycomb-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10513"
FT REGION 373..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 635 AA; 71620 MW; 5E79ED47BCB08D11 CRC64;
MTNNSKPKPS GSVPAALNVY KKVAIIRGSD DVLTYEDTDG NFKTVADLHL AAVATTPLNK
PKPNDEIPVP EIKYVDAYER DILPDYGCPT SYVRYNRLSH EELRESLEYV IDTEDETWLK
NSTKFGAASV VSLDDIKYSK EQSTGIDENT TGGIPSEDTS SAYTKRKAAK HLLKTTLLPL
SMLEIMFDIL EKATGFEAII TLDQAEYLIV KKLPQFYHMY PVRAKAGIVT IRHVMTDVYY
YWVSKRSKLK RPLIRRFWPV TSTDDTNPHL VFRPREKEKY KLRKKRQNDM DAYIKLQQLK
QDFSQIRLLM GLIQRREELN RSLILLQKEW FDQKLYDAID TSGLCRVSQD LDCKSLNELL
EVEKYFDINE VKRKRSRGRP SHQQQDGDDS SREGSRSTTP VPPSSSSSAV ALMGFGNTNT
GVTKNLDRNY PGVASGGPIG DLGSPKKAPM VIAGQNNGEP APSFLQPLIT RESYATTWEG
SVPHVTTIID GQPMPTYRFR HRPRVGRGGR LCIDRVPLPT DPNVVPNTYF RAGSRSSMSH
EPKERLLDLL PSPIDKDKLS RRIEEICISA LKEDYDAHAR PNGPPSTTAA VTTATASLED
ADDNDGTREV VVKMKDWLNT DEQLWGEERY AIGPI
//
