ID A0A1E7JHL7_9ACTN Unreviewed; 1014 AA.
AC A0A1E7JHL7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:OEU85984.1};
GN ORFNames=AN215_26915 {ECO:0000313|EMBL:OEU85984.1};
OS Streptomyces abyssalis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=933944 {ECO:0000313|EMBL:OEU85984.1, ECO:0000313|Proteomes:UP000176087};
RN [1] {ECO:0000313|EMBL:OEU85984.1, ECO:0000313|Proteomes:UP000176087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCSIO 10390 {ECO:0000313|EMBL:OEU85984.1,
RC ECO:0000313|Proteomes:UP000176087};
RX PubMed=27446038; DOI=10.3389/fmicb.2016.00998;
RA Tian X., Zhang Z., Yang T., Chen M., Li J., Chen F., Yang J., Li W.,
RA Zhang B., Zhang Z., Wu J., Zhang C., Long L., Xiao J.;
RT "Comparative Genomics Analysis of Streptomyces Species Reveals Their
RT Adaptation to the Marine Environment and Their Diversity at the Genomic
RT Level.";
RL Front. Microbiol. 7:998-998(2016).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEU85984.1}.
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DR EMBL; LJGT01000041; OEU85984.1; -; Genomic_DNA.
DR RefSeq; WP_070010609.1; NZ_LJGT01000041.1.
DR AlphaFoldDB; A0A1E7JHL7; -.
DR STRING; 933944.AN215_26915; -.
DR PATRIC; fig|933944.5.peg.3912; -.
DR OrthoDB; 9772207at2; -.
DR Proteomes; UP000176087; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR Gene3D; 2.60.40.2220; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000176087}.
FT DOMAIN 518..596
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1014 AA; 112038 MW; 4BC05EAE76D43A03 CRC64;
MHDDRRIVED RLRRVLAERI KPAVYSSPFP LTVERWDVPG EPVPVAEGLA ATYAPSKAGE
RWGPAWGTTW FKVTGQVPQE WQGRTVEAVL DLGFERNMPG FQCEGLIYRA DGEAVKALNP
RNDWVRIAEA AAGGEEVELF VEAAANPIVN TPQTPTYQGD RLTADDRPLY RLRRMDLALF
ETEVWELVQD LEVAGSLMRE LPLEDARRWE LLRAIEDSLD ALSLHDIVGT ASAARAALSG
VLSTPARPSA HRISAVGHAH IDSAWLWPVR ETVRKVARTA SNMVNLMDDH PEFVFAMSSA
QQLEWIKNYR PEVYAKVKKK VADGQFVPVG GMWVESDTNM VGGEAMARQF VYGKRFFLEE
FGVETKEVWL PDSFGYTAAM PQIVKLAGAK WFLTQKISWS ETNKFPHHTF WWEGIDGTRV
FTHFPPVDTY NSDLGGAEMA HAARNYREKG GASRSLAPFG WGDGGGGSTR EMLARAERLK
DLEGSPRVTV EKPSAFFSKA QEEYAQKAPV WAGELYLELH RGTYTSQAKT KQGNRHSESL
LREAELWSAT AAVRTGHTYP YEQLDELWKT VLLHQFHDIL PGSSIAWVHR EARETYARVR
AELEEIIAGA QAALAGDGDE PVVFNAAPHA RDGVAAGGAA PARERTGGTP VTAEARPGGG
WVLANGLLRI EVDGRGLVVS AYDKDARRES VAPGEAANLL QIHPDLPNHW DAWDVDSFYR
HNVTDLTGTD ELDLAESGEE SATVRVARSF GDSTVVQRLT LRAGSKVLDI DTEVDWHESE
MFLKAAFPLD VKADRSAGET QFGHVFRPTH TNTSWETAKF EICAHRWLQV EEPGWGAALV
NDSTYGHDVT RAVREDGGQT TTVRLSLLRA PRYPDPETDQ GTHRLRFALA PGASVGDAVR
EGHWINLPER TVRGAGGTVE PLIGVDNDQV VVEAVKLADD RSGDVVVRLY ESHGGRARAV
LRTGTPVTSV TETDLLERPL EETAATSAHV LSPDGSVEVT MRPFQILTLR FAKA
//
