ID A0A1E7KDV4_9ACTN Unreviewed; 334 AA.
AC A0A1E7KDV4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=2-oxoisovalerate dehydrogenase {ECO:0000313|EMBL:OEV02087.1};
GN ORFNames=AN217_02140 {ECO:0000313|EMBL:OEV02087.1};
OS Streptomyces qinglanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=943816 {ECO:0000313|EMBL:OEV02087.1, ECO:0000313|Proteomes:UP000175829};
RN [1] {ECO:0000313|EMBL:OEV02087.1, ECO:0000313|Proteomes:UP000175829}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCSIO M10379 {ECO:0000313|EMBL:OEV02087.1,
RC ECO:0000313|Proteomes:UP000175829};
RX PubMed=27446038; DOI=10.3389/fmicb.2016.00998;
RA Tian X., Zhang Z., Yang T., Chen M., Li J., Chen F., Yang J., Li W.,
RA Zhang B., Zhang Z., Wu J., Zhang C., Long L., Xiao J.;
RT "Comparative Genomics Analysis of Streptomyces Species Reveals Their
RT Adaptation to the Marine Environment and Their Diversity at the Genomic
RT Level.";
RL Front. Microbiol. 7:998-998(2016).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEV02087.1}.
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DR EMBL; LJGV01000021; OEV02087.1; -; Genomic_DNA.
DR RefSeq; WP_019356816.1; NZ_LJGV01000021.1.
DR AlphaFoldDB; A0A1E7KDV4; -.
DR PATRIC; fig|943816.4.peg.5519; -.
DR Proteomes; UP000175829; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000175829}.
FT DOMAIN 14..189
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 334 AA; 35888 MW; 4D38D5EE86C572D3 CRC64;
MAATGTASAA AQKLPVAKAI NSSLRTALEN DPKVLVMGED VGKLGGVFRV TDGLQKDFGE
DRVIDTPLAE SGIVGTAIGL ALRGYRPVVE IQFDGFVFPA YDQIVTQLAK MHARALGKIK
LPVVIRIPYG GGIGAVEHHS ESPEALFAHV AGLKCVSPSN ASDAYWMMQQ AIESDDPVIF
FEPKRRYWDK GEVDPSAIPA PLHSAQVARQ GSAVTVAAYG PMVKVCLEAA AAAEEEGNSL
EVVDLRSMSP IDFDTVQRSV EKTGRLVLVH EAPVFLGTGA EIAARITERC FYHLEAPVLR
VGGFHAPYPP ARLEDEYLPN LDRVLDAVDR ALAY
//
