ID A0A1E7KHF3_9ACTN Unreviewed; 574 AA.
AC A0A1E7KHF3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=AN216_11810 {ECO:0000313|EMBL:OEV03392.1};
OS Streptomyces oceani.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1075402 {ECO:0000313|EMBL:OEV03392.1, ECO:0000313|Proteomes:UP000176101};
RN [1] {ECO:0000313|EMBL:OEV03392.1, ECO:0000313|Proteomes:UP000176101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCSIO 02100 {ECO:0000313|EMBL:OEV03392.1,
RC ECO:0000313|Proteomes:UP000176101};
RX PubMed=27446038; DOI=10.3389/fmicb.2016.00998;
RA Tian X., Zhang Z., Yang T., Chen M., Li J., Chen F., Yang J., Li W.,
RA Zhang B., Zhang Z., Wu J., Zhang C., Long L., Xiao J.;
RT "Comparative Genomics Analysis of Streptomyces Species Reveals Their
RT Adaptation to the Marine Environment and Their Diversity at the Genomic
RT Level.";
RL Front. Microbiol. 7:998-998(2016).
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEV03392.1}.
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DR EMBL; LJGU01000120; OEV03392.1; -; Genomic_DNA.
DR RefSeq; WP_070196606.1; NZ_LJGU01000120.1.
DR AlphaFoldDB; A0A1E7KHF3; -.
DR STRING; 1075402.AN216_11810; -.
DR PATRIC; fig|1075402.3.peg.2560; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000176101; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:OEV03392.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000176101};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OEV03392.1}.
FT DOMAIN 21..249
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 307..537
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 59..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 59927 MW; B4E8ABC7E997F7B6 CRC64;
MSPTAAQTST THHLYGAHGH VTFLGAGPGD PGLLTLRAVE ALARADVLVA DPQVEGIVRP
HARSGVDTPT HSAPSAVEPV AEQGAPTATP TDPVADSPTG PASTGDRAHS VMAAARSGKR
VVRAVVGDPG LDTDAVQEML ACSAEGITFE VVPGVATAVG VPAYAGVPLR DAQGTDVRFI
DARTADDRCW TEAGASDATL VISTNLDLVA AAAGELVTTG RKPDTPLTVT LAGTTTRQRT
VTATLGTLAQ TLKANKLLPA ADSGQPVIAV VGERSASAQR QQLAWFESKP LFGWQVLVPR
TKEQAASLSE QLRSYGAVPA EVPTIAVEPP RTPQQMERAV KGLVTGRYEW IAFTSVNAVK
AVREKFEEYG LDARAFAGIK VAAVGEQTAA ALVEFGVKPD LVPSGEQSAA GLLEDWPPYD
AVFDPIDRVF LPRADIATET LVAGLIELGW EVDDVTAYRT VRASPPPADT REAIKGGGFD
AVLFTSSSTV RNLVGIAGKP HNVTVIACIG PATAKTAEEH GLRVDVLSPE PSVHKLAAAL
ADFGQKRRAD AVEAGETVKR PSEKRPARRR ARTS
//
