ID A0A1E7L8L0_9ACTN Unreviewed; 2001 AA.
AC A0A1E7L8L0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=TIR domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AN218_08070 {ECO:0000313|EMBL:OEV12498.1};
OS Streptomyces nanshensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=518642 {ECO:0000313|EMBL:OEV12498.1, ECO:0000313|Proteomes:UP000176005};
RN [1] {ECO:0000313|EMBL:OEV12498.1, ECO:0000313|Proteomes:UP000176005}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCSIO 10429 {ECO:0000313|EMBL:OEV12498.1,
RC ECO:0000313|Proteomes:UP000176005};
RX PubMed=27446038; DOI=10.3389/fmicb.2016.00998;
RA Tian X., Zhang Z., Yang T., Chen M., Li J., Chen F., Yang J., Li W.,
RA Zhang B., Zhang Z., Wu J., Zhang C., Long L., Xiao J.;
RT "Comparative Genomics Analysis of Streptomyces Species Reveals Their
RT Adaptation to the Marine Environment and Their Diversity at the Genomic
RT Level.";
RL Front. Microbiol. 7:998-998(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEV12498.1}.
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DR EMBL; LJGW01000138; OEV12498.1; -; Genomic_DNA.
DR RefSeq; WP_070016070.1; NZ_LJGW01000138.1.
DR PATRIC; fig|518642.10.peg.1440; -.
DR Proteomes; UP000176005; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00200; WD40; 2.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 2.160.20.80; E3 ubiquitin-protein ligase SopA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 5.
DR InterPro; IPR001646; 5peptide_repeat.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19879:SF1; CANNONBALL-RELATED; 1.
DR PANTHER; PTHR19879; TRANSCRIPTION INITIATION FACTOR TFIID; 1.
DR Pfam; PF12894; ANAPC4_WD40; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF00805; Pentapeptide; 2.
DR Pfam; PF13676; TIR_2; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00255; TIR; 1.
DR SMART; SM00320; WD40; 15.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF141571; Pentapeptide repeat-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS50837; NACHT; 1.
DR PROSITE; PS50104; TIR; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 12.
DR PROSITE; PS50294; WD_REPEATS_REGION; 9.
PE 4: Predicted;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 12..145
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT DOMAIN 750..868
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REPEAT 1323..1362
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1363..1396
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1408..1449
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1513..1554
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1604..1645
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1646..1687
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1688..1729
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1741..1761
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1772..1804
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1814..1846
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1854..1895
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1896..1937
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 144..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2001 AA; 215438 MW; FEF706ADD91369A7 CRC64;
MANNGELVGQ ARDLDFFISY SPADEQWAAW IAWTLEEAGY RTVIQAWDFV PGTNFIDFMD
RGVSDSVAVI AVLSSHYERS TYGRMEWQAA LRAEPEAPER KLLTVRVEDV PIEGLLATIT
YVDLVGVDDT ETARSMLLTR VGQAVEGHAR PSSQPGYPGG NGSGGAGRAT GLPGQRGAHP
GPYEQRDGGD GYDGRDAPHA ENEGRYGGHE ADAQRPLGRT GWPGRRRPAR APLYPAAPGS
GTAPQETLSV LHVAGPNFGR GREPDTLLRE MWSDLVELKD AGAPSPDLLV VSGDLTASGS
PRECDQALNF LTGLRSQLDL PPQRLVVVPG TQDVSQAACR GYFHTCEADE VPPQPPYWPK
WRHYTRLFRG LYHGMDTVFE SDQPWTLFPV PELHTVVAGF NSSIAFSHRT DDQYGFLGRD
QATWFSEALR TYEDEGWLRL GVVRHPLTAG RQRPGDAPGG PGPLRDADTF ARLTARRLHL
VLHGPTGGPR TTSSEPSYGQ LSTPAGELPL FGSAAPARCE LLRIGPRGVT RWTDEAGAEP
ADFPLEWRSA HRVFAVPDEP VPALPTAAAE DGDDDRPLDE PADSLAERVR EVCRARREGV
RLRDVPRQEA GDMVQLMATW HEEGVVRQQR IAIHPGTPTE AEIDRFVAQA HATDTGSEAE
IVHEGPAPER PLRERASRRG VRVRSFLEFQ GLLDLRAYVA AQTASLAADD RYPPGLYLPG
RYRDAERPEG AERSGLVENM LDLLAADHGR FILLLGDFGH GKTFALRELA RRIPEQLPHL
TPLFIPLNTL DRAHSLEGLV AAHLASHGVD TIDLRALRYM LGQGRVVLLF DGFDELVNRV
SYDRAADHLQ VLLDASVDNA KIVVSSRTQH FKSQAQILTA LGERVGMLPR RRVLSLEGFG
PAQIRTYLGN RYGDEEVAAQ RFRLLENIPD LLELCANPRL LSFVADLAPE QLRAVAGAGR
ALSPAGLYED VFSAWLAFEE RRGQGGPGAA PGLSAEHLWA AVTALAQRLW ESGRSALRLD
ELTETVAETL SGLAGSSAMS TQESAQAVGA GTLLARTEDG LFHFIHGSVV EWLVAREAAA
QLTRGEDALL AARPLTQLAV EFFCDLADHT LCTAWVQDVL NSPGPRTSEA ARANAVRIID
RLRVPADADL RAARLVGEDL SARDFSGVDL TGADLTDTRL LGTNLAGAVL RDAVLVGARL
DEADLRDADL TGADLRRARL TRTDLRGARL EGSRWMRAAL IDPVTDGQLD APELATAAVA
PGMPVEAGLR PSAVGVPYGF DMRTSRLPEP VSYSPDGELL AVGSEDGGVL VCAADTGRAV
RTLHGHEGRV YAVKFRAGVL ATGAADGEVR LWDPVSGRCL HRLEVHPGGV WPVALDAEGT
VLATGDAEGL VTLWNVTGPD AGAPLHRLPG HAAPVYTAVF SPDGGTLVTG DADAVLRVWD
TRTGRCTAEL HEHQGALYRA RFSPDGTLLA TGDRGGRDGQ GTVRVWDMTG TTADDDGRSG
GEDAQPPRLL HELTGHTGHV YTLDFHPAAA LLVSGDTDGR VRLWDPRTGA EAGTPERCAG
GVYQVLFGDE GRLLAACDSA GTVRMWRVTP TAGGHSVTLL PQQPVEHRGS AWACAFRPRD
RQLLTVGNDG GAQIWDAGTG QGKRILRGHG RRVNTLAFSA DGTGLATAGN DGTVRLWDAR
TGRRTAELSG RGDRLVSAVF SPAGPVLGTA SNDGDVYLWN AETGEYLREI DVETDHTWAE
AFSGDGELLA TANDDDTVRL WWRSTGAHVT TLTLHRGRVR SIAFRADGGL LATGCDDSRV
RLWEPYSGGL VADLEGHSDR VYAVTFCHGE SALLSASWDG TAAIWEDGEL RHVLRGHTGR
LWTAAAHPRR PLVATAGDDR AICLWDAGSG ERTARLTGHT GRIHTLAFSP DGSRLASGGE
DGTVRLWHVP DDAEPEAAPE PVATLIGVPG GWAALTPGGG YKYEGDVAGE FWHVVGMARF
APGELDAYLP GVHRLALDAE L
//
