ID A0A1E7MYH4_KITAU Unreviewed; 419 AA.
AC A0A1E7MYH4; A0A8H9LM67;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Squalene cyclase C-terminal domain-containing protein {ECO:0000259|Pfam:PF13243};
GN ORFNames=GCM10010502_08600 {ECO:0000313|EMBL:GGU60405.1}, HS99_0013060
GN {ECO:0000313|EMBL:OEV33488.1};
OS Kitasatospora aureofaciens (Streptomyces aureofaciens).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=1894 {ECO:0000313|EMBL:OEV33488.1, ECO:0000313|Proteomes:UP000037395};
RN [1] {ECO:0000313|EMBL:OEV33488.1, ECO:0000313|Proteomes:UP000037395}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10762 {ECO:0000313|EMBL:OEV33488.1}, and ATCC 10762 / DSM
RC 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 /
RC A-377 {ECO:0000313|Proteomes:UP000037395};
RA Zhang J.E., Yang H., Guo J., Deng Z., Luo H., Luo M., Zhao B.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000037395}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC
RC 12843 / NCIMB 8234 / A-377 {ECO:0000313|Proteomes:UP000037395};
RA Gradnigo J.S., Johnson N., Somerville G.A.;
RT "Sequencing, assembly and comparative genomics of S. aureofaciens ATCC
RT 10762.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:OEV33488.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10762 {ECO:0000313|EMBL:OEV33488.1};
RA Gradnigo J.S., Johnson N., Somerville G.A.;
RT "Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC
RT 10762.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:GGU60405.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 4434 {ECO:0000313|EMBL:GGU60405.1};
RX PubMed=30832757;
RA Wu L., Ma J.;
RT "The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing
RT project: providing services to taxonomists for standard genome sequencing
RT and annotation.";
RL Int. J. Syst. Evol. Microbiol. 69:895-898(2019).
RN [5] {ECO:0000313|EMBL:GGU60405.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 4434 {ECO:0000313|EMBL:GGU60405.1};
RA Sun Q., Ohkuma M.;
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the terpene synthase family.
CC {ECO:0000256|ARBA:ARBA00006333}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEV33488.1}.
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DR EMBL; BMUB01000002; GGU60405.1; -; Genomic_DNA.
DR EMBL; JPRF03000065; OEV33488.1; -; Genomic_DNA.
DR RefSeq; WP_030282329.1; NZ_LBHA01000528.1.
DR AlphaFoldDB; A0A1E7MYH4; -.
DR GeneID; 78696565; -.
DR OrthoDB; 3852853at2; -.
DR Proteomes; UP000037395; Unassembled WGS sequence.
DR Proteomes; UP000610124; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00688; ISOPREN_C2_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000037395};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..419
FT /note="Squalene cyclase C-terminal domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5034740569"
FT TRANSMEM 392..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..144
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 419 AA; 41433 MW; C8FDD8FFC9932412 CRC64;
MLTAARLGAA ALSAALLAGV AAGPALADSP SPGATTAAVP DGLYGKGDPT YDGVWRQSLA
LTALTAAKVT PADSAVGWLT GQQCEDGGWP SYRAAGAACD AKTEDSNATA VAIQALVALG
GHQPAVDKGV QWLRANQNAD GSWPYNPGNP GDANSTGLAV NALFAARTDP AGVARPGTGG
AAGKNAFEGL ARFQLGCTAP ADQRGAFAYQ PDPTGALAPN TLASAQAALA AAGGHLPVAT
SVHADASPKA LACADGSAPA TIPHAESGEA VGAYLGAQLA AGDEHLTLTT PGADPKPDYT
ATAWAALALI QSGHPEQATD AVDWLEGQGD TWTKNGTDAA ATASLLMVSQ AAHRSTADLT
GKLTALGPVP KGGAAAAEAT PVKKKGDGMG QFWLIVVGLL IGIGGGLLLS LQRKRNPNL
//
